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P74155

- YIDC_SYNY3

UniProt

P74155 - YIDC_SYNY3

Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Required for the insertion of integral membrane proteins into the membrane. Probably plays an essential role in the integration of proteins of the respiratory chain complexes. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex By similarity. Addition of green fluorescent protein (GFP) to the C-terminus leads to photoinhibition at 80 µmol/m2/s light intensity, reduced amounts of pigment, altered energy transfer between the antenna systems and the reaction centers of PSI and PSII, and impaired integration of PSII reaction center protein D1 into membranes, suggesting it probably also aids protein insertion, folding and/or assembly of membrane complexes destined for the thylakoid.By similarity2 Publications

    GO - Biological processi

    1. protein insertion into membrane Source: InterPro
    2. protein transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane protein insertase YidC
    Alternative name(s):
    Alb3
    Foldase YidC
    Membrane integrase YidC
    Membrane protein YidC
    Oxa1
    SynYidC
    Gene namesi
    Name:yidC
    Synonyms:alb3
    Ordered Locus Names:slr1471
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cell inner membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Merodiplod cells have greatly altered thylakoid morphology, and about 40% photosynthetic pigements, photosynthetic electron transport and oxygen evolution.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Membrane protein insertase YidCPRO_0000124759Add
    BLAST

    Proteomic databases

    PaxDbiP74155.

    Interactioni

    Subunit structurei

    Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity. Interacts with the precursor of PSII reaction center D1.By similarity1 Publication

    Protein-protein interaction databases

    IntActiP74155. 19 interactions.
    STRINGi1148.slr1471.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0706.
    KOiK03217.
    OMAiMITGMFL.
    OrthoDBiEOG6X6RF2.

    Family and domain databases

    InterProiIPR028055. Membr_insert_YidC/Oxa1_C.
    IPR001708. Membrane_insert_OXA1/ALB3/YidC.
    [Graphical view]
    PANTHERiPTHR12428. PTHR12428. 1 hit.
    PfamiPF02096. 60KD_IMP. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P74155-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFGIGFIST NIMLPILDFF FGIVHSYGFA IIALTLVIRL GLYPLSAGQI    50
    RNMRKMRITQ PLMKERQEEI QKRYKDDPAK QQEEMAKVMK EFGNPLAGCL 100
    PLLLQMPILF ALFATLRGSP FSDINYTVDL QILPQEQVER IVPQTFSTKP 150
    QNIYVDEALH YPIAVFLPGG KMLGVGEKTQ LEIQSTEGKA FNQVIPEKNS 200
    QILTPTYSVT KGEDRISVNP DGTIEALVPG DATVQVTIPG IAARTGFLFI 250
    KALGQVGVTG ENGEINWDIL GMIVFFGFSI YLNQELSGAS GGGAPNAQAQ 300
    QQQTINKITP ILFSGMFLFF PLPAGVLMYI VMANVFQTIQ TLILMREPLP 350
    ENLQKLLDEQ QKATQGRESL PFEKKSSKKK EKTS 384
    Length:384
    Mass (Da):42,627
    Last modified:February 1, 1997 - v1
    Checksum:iA90CEE83C43C12C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18244.1.
    PIRiS75683.
    RefSeqiNP_441564.1. NC_000911.1.
    YP_005651622.1. NC_017277.1.
    YP_007451446.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18244; BAA18244; BAA18244.
    GeneIDi953096.
    KEGGisyn:slr1471.
    syy:SYNGTS_1669.
    syz:MYO_116850.
    PATRICi23840557. VBISynSp132158_1835.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18244.1 .
    PIRi S75683.
    RefSeqi NP_441564.1. NC_000911.1.
    YP_005651622.1. NC_017277.1.
    YP_007451446.1. NC_020286.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P74155. 19 interactions.
    STRINGi 1148.slr1471.

    Proteomic databases

    PaxDbi P74155.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18244 ; BAA18244 ; BAA18244 .
    GeneIDi 953096.
    KEGGi syn:slr1471.
    syy:SYNGTS_1669.
    syz:MYO_116850.
    PATRICi 23840557. VBISynSp132158_1835.

    Phylogenomic databases

    eggNOGi COG0706.
    KOi K03217.
    OMAi MITGMFL.
    OrthoDBi EOG6X6RF2.

    Family and domain databases

    InterProi IPR028055. Membr_insert_YidC/Oxa1_C.
    IPR001708. Membrane_insert_OXA1/ALB3/YidC.
    [Graphical view ]
    PANTHERi PTHR12428. PTHR12428. 1 hit.
    Pfami PF02096. 60KD_IMP. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03592. yidC_oxa1_cterm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.
    2. "A homolog of Albino3/OxaI is essential for thylakoid biogenesis in the cyanobacterium Synechocystis sp. PCC6803."
      Spence E., Bailey S., Nenninger A., Moller S.G., Robinson C.
      J. Biol. Chem. 279:55792-55800(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    3. "The synechocystis sp PCC 6803 oxa1 homolog is essential for membrane integration of reaction center precursor protein pD1."
      Ossenbuhl F., Inaba-Sulpice M., Meurer J., Soll J., Eichacker L.A.
      Plant Cell 18:2236-2246(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ASSEMBLY OF D1, INTERACTION WITH D1, SUBCELLULAR LOCATION.
      Strain: ATCC 27184 / PCC 6803 / N-1.
    4. "A conserved structure and function of the YidC homologous protein Slr1471 from Synechocystis sp. PCC 6803."
      Sven G., Eva R., Uwe K., Schneider D.
      J. Microbiol. Biotechnol. 18:1090-1094(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: ATCC 27184 / PCC 6803 / N-1.

    Entry informationi

    Entry nameiYIDC_SYNY3
    AccessioniPrimary (citable) accession number: P74155
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3