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P74155 (YIDC_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane protein insertase YidC
Alternative name(s):
Alb3
Foldase YidC
Membrane integrase YidC
Membrane protein YidC
Oxa1
SynYidC
Gene names
Name:yidC
Synonyms:alb3
Ordered Locus Names:slr1471
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the insertion of integral membrane proteins into the membrane. Probably plays an essential role in the integration of proteins of the respiratory chain complexes. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex By similarity. Addition of green fluorescent protein (GFP) to the C-terminus leads to photoinhibition at 80 µmol/m2/s light intensity, reduced amounts of pigment, altered energy transfer between the antenna systems and the reaction centers of PSI and PSII, and impaired integration of PSII reaction center protein D1 into membranes, suggesting it probably also aids protein insertion, folding and/or assembly of membrane complexes destined for the thylakoid. Ref.2 Ref.3

Subunit structure

Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity. Interacts with the precursor of PSII reaction center D1. Ref.3

Subcellular location

Cell inner membrane; Multi-pass membrane protein Ref.3 Ref.4.

Disruption phenotype

Merodiplod cells have greatly altered thylakoid morphology, and about 40% photosynthetic pigements, photosynthetic electron transport and oxygen evolution. Ref.2

Sequence similarities

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein insertion into membrane

Inferred from electronic annotation. Source: InterPro

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Membrane protein insertase YidC
PRO_0000124759

Regions

Transmembrane12 – 3221Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane311 – 33121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P74155 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: A90CEE83C43C12C0

FASTA38442,627
        10         20         30         40         50         60 
MDFGIGFIST NIMLPILDFF FGIVHSYGFA IIALTLVIRL GLYPLSAGQI RNMRKMRITQ 

        70         80         90        100        110        120 
PLMKERQEEI QKRYKDDPAK QQEEMAKVMK EFGNPLAGCL PLLLQMPILF ALFATLRGSP 

       130        140        150        160        170        180 
FSDINYTVDL QILPQEQVER IVPQTFSTKP QNIYVDEALH YPIAVFLPGG KMLGVGEKTQ 

       190        200        210        220        230        240 
LEIQSTEGKA FNQVIPEKNS QILTPTYSVT KGEDRISVNP DGTIEALVPG DATVQVTIPG 

       250        260        270        280        290        300 
IAARTGFLFI KALGQVGVTG ENGEINWDIL GMIVFFGFSI YLNQELSGAS GGGAPNAQAQ 

       310        320        330        340        350        360 
QQQTINKITP ILFSGMFLFF PLPAGVLMYI VMANVFQTIQ TLILMREPLP ENLQKLLDEQ 

       370        380 
QKATQGRESL PFEKKSSKKK EKTS 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.
[2]"A homolog of Albino3/OxaI is essential for thylakoid biogenesis in the cyanobacterium Synechocystis sp. PCC6803."
Spence E., Bailey S., Nenninger A., Moller S.G., Robinson C.
J. Biol. Chem. 279:55792-55800(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[3]"The synechocystis sp PCC 6803 oxa1 homolog is essential for membrane integration of reaction center precursor protein pD1."
Ossenbuhl F., Inaba-Sulpice M., Meurer J., Soll J., Eichacker L.A.
Plant Cell 18:2236-2246(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN ASSEMBLY OF D1, INTERACTION WITH D1, SUBCELLULAR LOCATION.
Strain: ATCC 27184 / PCC 6803 / N-1.
[4]"A conserved structure and function of the YidC homologous protein Slr1471 from Synechocystis sp. PCC 6803."
Sven G., Eva R., Uwe K., Schneider D.
J. Microbiol. Biotechnol. 18:1090-1094(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: ATCC 27184 / PCC 6803 / N-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA18244.1.
PIRS75683.
RefSeqNP_441564.1. NC_000911.1.
YP_005651622.1. NC_017277.1.
YP_007451446.1. NC_020286.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP74155. 19 interactions.
STRING1148.slr1471.

Proteomic databases

PaxDbP74155.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA18244; BAA18244; BAA18244.
GeneID12254275.
14617107.
953096.
KEGGsyn:slr1471.
syy:SYNGTS_1669.
syz:MYO_116850.
PATRIC23840557. VBISynSp132158_1835.

Phylogenomic databases

eggNOGCOG0706.
KOK03217.
OMAMITGMFL.
OrthoDBEOG6X6RF2.
ProtClustDBPRK02654.

Family and domain databases

InterProIPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERPTHR12428. PTHR12428. 1 hit.
PfamPF02096. 60KD_IMP. 1 hit.
[Graphical view]
TIGRFAMsTIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNetSearch...

Entry information

Entry nameYIDC_SYNY3
AccessionPrimary (citable) accession number: P74155
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: February 1, 1997
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families