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P74155

- YIDC_SYNY3

UniProt

P74155 - YIDC_SYNY3

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Protein
Membrane protein insertase YidC
Gene
yidC, alb3, slr1471
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for the insertion of integral membrane proteins into the membrane. Probably plays an essential role in the integration of proteins of the respiratory chain complexes. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex By similarity. Addition of green fluorescent protein (GFP) to the C-terminus leads to photoinhibition at 80 µmol/m2/s light intensity, reduced amounts of pigment, altered energy transfer between the antenna systems and the reaction centers of PSI and PSII, and impaired integration of PSII reaction center protein D1 into membranes, suggesting it probably also aids protein insertion, folding and/or assembly of membrane complexes destined for the thylakoid.2 Publications

GO - Biological processi

  1. protein insertion into membrane Source: InterPro
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidC
Alternative name(s):
Alb3
Foldase YidC
Membrane integrase YidC
Membrane protein YidC
Oxa1
SynYidC
Gene namesi
Name:yidC
Synonyms:alb3
Ordered Locus Names:slr1471
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cell inner membrane; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221Helical; Reviewed prediction
Add
BLAST
Transmembranei96 – 11621Helical; Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Merodiplod cells have greatly altered thylakoid morphology, and about 40% photosynthetic pigements, photosynthetic electron transport and oxygen evolution.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Membrane protein insertase YidC
PRO_0000124759Add
BLAST

Proteomic databases

PaxDbiP74155.

Interactioni

Subunit structurei

Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity. Interacts with the precursor of PSII reaction center D1.1 Publication

Protein-protein interaction databases

IntActiP74155. 19 interactions.
STRINGi1148.slr1471.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0706.
KOiK03217.
OMAiMITGMFL.
OrthoDBiEOG6X6RF2.

Family and domain databases

InterProiIPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

P74155-1 [UniParc]FASTAAdd to Basket

« Hide

MDFGIGFIST NIMLPILDFF FGIVHSYGFA IIALTLVIRL GLYPLSAGQI    50
RNMRKMRITQ PLMKERQEEI QKRYKDDPAK QQEEMAKVMK EFGNPLAGCL 100
PLLLQMPILF ALFATLRGSP FSDINYTVDL QILPQEQVER IVPQTFSTKP 150
QNIYVDEALH YPIAVFLPGG KMLGVGEKTQ LEIQSTEGKA FNQVIPEKNS 200
QILTPTYSVT KGEDRISVNP DGTIEALVPG DATVQVTIPG IAARTGFLFI 250
KALGQVGVTG ENGEINWDIL GMIVFFGFSI YLNQELSGAS GGGAPNAQAQ 300
QQQTINKITP ILFSGMFLFF PLPAGVLMYI VMANVFQTIQ TLILMREPLP 350
ENLQKLLDEQ QKATQGRESL PFEKKSSKKK EKTS 384
Length:384
Mass (Da):42,627
Last modified:February 1, 1997 - v1
Checksum:iA90CEE83C43C12C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18244.1.
PIRiS75683.
RefSeqiNP_441564.1. NC_000911.1.
YP_005651622.1. NC_017277.1.
YP_007451446.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18244; BAA18244; BAA18244.
GeneIDi953096.
KEGGisyn:slr1471.
syy:SYNGTS_1669.
syz:MYO_116850.
PATRICi23840557. VBISynSp132158_1835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18244.1 .
PIRi S75683.
RefSeqi NP_441564.1. NC_000911.1.
YP_005651622.1. NC_017277.1.
YP_007451446.1. NC_020286.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P74155. 19 interactions.
STRINGi 1148.slr1471.

Proteomic databases

PaxDbi P74155.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18244 ; BAA18244 ; BAA18244 .
GeneIDi 953096.
KEGGi syn:slr1471.
syy:SYNGTS_1669.
syz:MYO_116850.
PATRICi 23840557. VBISynSp132158_1835.

Phylogenomic databases

eggNOGi COG0706.
KOi K03217.
OMAi MITGMFL.
OrthoDBi EOG6X6RF2.

Family and domain databases

InterProi IPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view ]
PANTHERi PTHR12428. PTHR12428. 1 hit.
Pfami PF02096. 60KD_IMP. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  2. "A homolog of Albino3/OxaI is essential for thylakoid biogenesis in the cyanobacterium Synechocystis sp. PCC6803."
    Spence E., Bailey S., Nenninger A., Moller S.G., Robinson C.
    J. Biol. Chem. 279:55792-55800(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  3. "The synechocystis sp PCC 6803 oxa1 homolog is essential for membrane integration of reaction center precursor protein pD1."
    Ossenbuhl F., Inaba-Sulpice M., Meurer J., Soll J., Eichacker L.A.
    Plant Cell 18:2236-2246(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ASSEMBLY OF D1, INTERACTION WITH D1, SUBCELLULAR LOCATION.
    Strain: ATCC 27184 / PCC 6803 / N-1.
  4. "A conserved structure and function of the YidC homologous protein Slr1471 from Synechocystis sp. PCC 6803."
    Sven G., Eva R., Uwe K., Schneider D.
    J. Microbiol. Biotechnol. 18:1090-1094(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: ATCC 27184 / PCC 6803 / N-1.

Entry informationi

Entry nameiYIDC_SYNY3
AccessioniPrimary (citable) accession number: P74155
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi