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P74133 (HO2_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heme oxygenase 2

EC=1.14.99.3
Gene names
Name:pbsA2
Ordered Locus Names:sll1875
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae By similarity.

Catalytic activity

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Subunit structure

Homodimer. Ref.2

Sequence similarities

Belongs to the heme oxygenase family.

Ontologies

Keywords
   Biological processPhotosynthesis
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheme oxidation

Inferred from electronic annotation. Source: InterPro

photosynthesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionheme oxygenase (decyclizing) activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Heme oxygenase 2
PRO_0000209702

Sites

Metal binding161Iron (heme axial ligand)

Secondary structure

..................................... 250
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P74133 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: F3F54814D51709FC

FASTA25028,540
        10         20         30         40         50         60 
MTNLAQKLRY GTQQSHTLAE NTAYMKCFLK GIVEREPFRQ LLANLYYLYS ALEAALRQHR 

        70         80         90        100        110        120 
DNEIISAIYF PELNRTDKLA EDLTYYYGPN WQQIIQPTPC AKIYVDRLKT IAASEPELLI 

       130        140        150        160        170        180 
AHCYTRYLGD LSGGQSLKNI IRSALQLPEG EGTAMYEFDS LPTPGDRRQF KEIYRDVLNS 

       190        200        210        220        230        240 
LPLDEATINR IVEEANYAFS LNREVMHDLE DLIKAAIGEH TFDLLTRQDR PGSTEARSTA 

       250 
GHPITLMVGE 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.
[2]"Crystal structure of dimeric heme oxygenase-2 from Synechocystis sp. PCC 6803 in complex with heme."
Sugishima M., Hagiwara Y., Zhang X., Yoshida T., Migita C.T., Fukuyama K.
Biochemistry 44:4257-4266(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH HEME, SUBUNIT, IRON-BINDING SITE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA18219.1.
PIRS75658.
RefSeqNP_441539.1. NC_000911.1.
YP_005651597.1. NC_017277.1.
YP_007451421.1. NC_020286.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WOVX-ray1.75A/B1-250[»]
1WOWX-ray2.20A/B1-250[»]
1WOXX-ray2.10A/B1-250[»]
ProteinModelPortalP74133.
SMRP74133. Positions 2-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP74133. 2 interactions.
STRING1148.sll1875.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA18219; BAA18219; BAA18219.
GeneID12254249.
14617081.
953111.
KEGGsyn:sll1875.
syy:SYNGTS_1644.
syz:MYO_116590.
PATRIC23840501. VBISynSp132158_1808.

Phylogenomic databases

eggNOGCOG5398.
HOGENOMHOG000233221.
KOK00510.
OMAGQDWREK.
OrthoDBEOG69PQ2G.
PhylomeDBP74133.
ProtClustDBCLSK2301868.

Family and domain databases

Gene3D1.20.910.10. 1 hit.
InterProIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERPTHR10720. PTHR10720. 1 hit.
PfamPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFPIRSF000343. Haem_Oase. 1 hit.
PRINTSPR00088. HAEMOXYGNASE.
SUPFAMSSF48613. SSF48613. 1 hit.
PROSITEPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP74133.

Entry information

Entry nameHO2_SYNY3
AccessionPrimary (citable) accession number: P74133
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references