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P74133

- HO2_SYNY3

UniProt

P74133 - HO2_SYNY3

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Protein

Heme oxygenase 2

Gene

pbsA2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae By similarity.By similarity

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi16 – 161Iron (heme axial ligand)

GO - Molecular functioni

  1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme oxidation Source: InterPro
  2. photosynthesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Photosynthesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase 2 (EC:1.14.99.3)
Gene namesi
Name:pbsA2
Ordered Locus Names:sll1875
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Heme oxygenase 2PRO_0000209702Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiP74133. 2 interactions.
STRINGi1148.sll1875.

Structurei

Secondary structure

1
250
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 118
Helixi13 – 208
Helixi23 – 308
Helixi35 – 5824
Turni59 – 613
Helixi63 – 686
Helixi71 – 733
Helixi76 – 8712
Helixi91 – 944
Helixi99 – 11416
Helixi116 – 1183
Helixi119 – 13012
Helixi133 – 14412
Helixi154 – 1563
Helixi164 – 18017
Helixi185 – 20723
Helixi210 – 2178
Helixi219 – 2268
Beta strandi243 – 2475

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WOVX-ray1.75A/B1-250[»]
1WOWX-ray2.20A/B1-250[»]
1WOXX-ray2.10A/B1-250[»]
ProteinModelPortaliP74133.
SMRiP74133. Positions 2-250.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP74133.

Family & Domainsi

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Phylogenomic databases

eggNOGiCOG5398.
HOGENOMiHOG000233221.
InParanoidiP74133.
KOiK00510.
OMAiAIGEHTF.
OrthoDBiEOG69PQ2G.
PhylomeDBiP74133.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74133-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNLAQKLRY GTQQSHTLAE NTAYMKCFLK GIVEREPFRQ LLANLYYLYS
60 70 80 90 100
ALEAALRQHR DNEIISAIYF PELNRTDKLA EDLTYYYGPN WQQIIQPTPC
110 120 130 140 150
AKIYVDRLKT IAASEPELLI AHCYTRYLGD LSGGQSLKNI IRSALQLPEG
160 170 180 190 200
EGTAMYEFDS LPTPGDRRQF KEIYRDVLNS LPLDEATINR IVEEANYAFS
210 220 230 240 250
LNREVMHDLE DLIKAAIGEH TFDLLTRQDR PGSTEARSTA GHPITLMVGE
Length:250
Mass (Da):28,540
Last modified:February 1, 1997 - v1
Checksum:iF3F54814D51709FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18219.1.
PIRiS75658.
RefSeqiNP_441539.1. NC_000911.1.
YP_005651597.1. NC_017277.1.
YP_007451421.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18219; BAA18219; BAA18219.
GeneIDi953111.
KEGGisyn:sll1875.
syy:SYNGTS_1644.
syz:MYO_116590.
PATRICi23840501. VBISynSp132158_1808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18219.1 .
PIRi S75658.
RefSeqi NP_441539.1. NC_000911.1.
YP_005651597.1. NC_017277.1.
YP_007451421.1. NC_020286.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WOV X-ray 1.75 A/B 1-250 [» ]
1WOW X-ray 2.20 A/B 1-250 [» ]
1WOX X-ray 2.10 A/B 1-250 [» ]
ProteinModelPortali P74133.
SMRi P74133. Positions 2-250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P74133. 2 interactions.
STRINGi 1148.sll1875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18219 ; BAA18219 ; BAA18219 .
GeneIDi 953111.
KEGGi syn:sll1875.
syy:SYNGTS_1644.
syz:MYO_116590.
PATRICi 23840501. VBISynSp132158_1808.

Phylogenomic databases

eggNOGi COG5398.
HOGENOMi HOG000233221.
InParanoidi P74133.
KOi K00510.
OMAi AIGEHTF.
OrthoDBi EOG69PQ2G.
PhylomeDBi P74133.

Miscellaneous databases

EvolutionaryTracei P74133.

Family and domain databases

Gene3Di 1.20.910.10. 1 hit.
InterProi IPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view ]
PANTHERi PTHR10720. PTHR10720. 1 hit.
Pfami PF01126. Heme_oxygenase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000343. Haem_Oase. 1 hit.
PRINTSi PR00088. HAEMOXYGNASE.
SUPFAMi SSF48613. SSF48613. 1 hit.
PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  2. "Crystal structure of dimeric heme oxygenase-2 from Synechocystis sp. PCC 6803 in complex with heme."
    Sugishima M., Hagiwara Y., Zhang X., Yoshida T., Migita C.T., Fukuyama K.
    Biochemistry 44:4257-4266(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH HEME, SUBUNIT, IRON-BINDING SITE.

Entry informationi

Entry nameiHO2_SYNY3
AccessioniPrimary (citable) accession number: P74133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3