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Protein

Heme oxygenase 2

Gene

pbsA2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae.By similarity

Catalytic activityi

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi16Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPhotosynthesis
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase 2 (EC:1.14.14.18By similarity)
Gene namesi
Name:pbsA2
Ordered Locus Names:sll1875
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097021 – 250Heme oxygenase 2Add BLAST250

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiP74133. 2 interactors.
STRINGi1148.SYNGTS_1644.

Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 11Combined sources8
Helixi13 – 20Combined sources8
Helixi23 – 30Combined sources8
Helixi35 – 58Combined sources24
Turni59 – 61Combined sources3
Helixi63 – 68Combined sources6
Helixi71 – 73Combined sources3
Helixi76 – 87Combined sources12
Helixi91 – 94Combined sources4
Helixi99 – 114Combined sources16
Helixi116 – 118Combined sources3
Helixi119 – 130Combined sources12
Helixi133 – 144Combined sources12
Helixi154 – 156Combined sources3
Helixi164 – 180Combined sources17
Helixi185 – 207Combined sources23
Helixi210 – 217Combined sources8
Helixi219 – 226Combined sources8
Beta strandi243 – 247Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WOVX-ray1.75A/B1-250[»]
1WOWX-ray2.20A/B1-250[»]
1WOXX-ray2.10A/B1-250[»]
ProteinModelPortaliP74133.
SMRiP74133.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP74133.

Family & Domainsi

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Phylogenomic databases

HOGENOMiHOG000233221.
InParanoidiP74133.
KOiK21480.
OMAiHRKEALT.
PhylomeDBiP74133.

Family and domain databases

CDDicd00232. HemeO. 1 hit.
Gene3Di1.20.910.10. 1 hit.
InterProiView protein in InterPro
IPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiView protein in Pfam
PF01126. Heme_oxygenase. 1 hit.
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiView protein in PROSITE
PS00593. HEME_OXYGENASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P74133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLAQKLRY GTQQSHTLAE NTAYMKCFLK GIVEREPFRQ LLANLYYLYS
60 70 80 90 100
ALEAALRQHR DNEIISAIYF PELNRTDKLA EDLTYYYGPN WQQIIQPTPC
110 120 130 140 150
AKIYVDRLKT IAASEPELLI AHCYTRYLGD LSGGQSLKNI IRSALQLPEG
160 170 180 190 200
EGTAMYEFDS LPTPGDRRQF KEIYRDVLNS LPLDEATINR IVEEANYAFS
210 220 230 240 250
LNREVMHDLE DLIKAAIGEH TFDLLTRQDR PGSTEARSTA GHPITLMVGE
Length:250
Mass (Da):28,540
Last modified:February 1, 1997 - v1
Checksum:iF3F54814D51709FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18219.1.
PIRiS75658.

Genome annotation databases

EnsemblBacteriaiBAA18219; BAA18219; BAA18219.
KEGGisyn:sll1875.

Similar proteinsi

Entry informationi

Entry nameiHO2_SYNY3
AccessioniPrimary (citable) accession number: P74133
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: September 27, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names