Heme oxygenase 2 - Synechocystis sp. (strain PCC 6803)

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Reviewed, UniProtKB/Swiss-Prot P74133 (HO2_SYNY3)

Last modified June 16, 2009. Version 60. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Heme oxygenase 2
EC=1.14.99.3

Gene names

Name:	pbsA2
Ordered Locus Names:	sll1875

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

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Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae By similarity.
Catalytic activity	Heme + 3 AH₂ + 3 O₂ = biliverdin + Fe²⁺ + CO + 3 A + 3 H₂O.
Subunit structure	Homodimer. Ref.2
Sequence similarities	Belongs to the heme oxygenase family.

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Ontologies

Keywords
Biological process	Photosynthesis
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	heme oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 250

250

Heme oxygenase 2

PRO_0000209702

Sites

Metal binding

Iron (heme axial ligand)

Secondary structure

250

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P74133-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: F3F54814D51709FC
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FASTA

250

28,540

        10         20         30         40         50         60 
MTNLAQKLRY GTQQSHTLAE NTAYMKCFLK GIVEREPFRQ LLANLYYLYS ALEAALRQHR 

        70         80         90        100        110        120 
DNEIISAIYF PELNRTDKLA EDLTYYYGPN WQQIIQPTPC AKIYVDRLKT IAASEPELLI 

       130        140        150        160        170        180 
AHCYTRYLGD LSGGQSLKNI IRSALQLPEG EGTAMYEFDS LPTPGDRRQF KEIYRDVLNS 

       190        200        210        220        230        240 
LPLDEATINR IVEEANYAFS LNREVMHDLE DLIKAAIGEH TFDLLTRQDR PGSTEARSTA 

       250 
GHPITLMVGE

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Crystal structure of dimeric heme oxygenase-2 from Synechocystis sp. PCC 6803 in complex with heme." Sugishima M., Hagiwara Y., Zhang X., Yoshida T., Migita C.T., Fukuyama K. Biochemistry 44:4257-4266(2005) [PubMed: 15766254] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH HEME, SUBUNIT, IRON-BINDING SITE.

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Cross-references

Sequence databases

BA000022 Genomic DNA. Translation: BAA18219.1.

PIR

S75658.

RefSeq

NP_441539.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WOV	X-ray	1.75	A/B	1-250	[»]
1WOW	X-ray	2.20	A/B	1-250	[»]
1WOX	X-ray	2.10	A/B	1-250	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P74133. 2 interactions.

Genome annotation databases

GeneID

953111.

GenomeReviews

Gene locus sll1875 in contig BA000022_GR.

KEGG

syn:sll1875.

NMPDR

fig|1148.1.peg.1640.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

P74133.

OMA

P74133. FLKGIVE.

Enzyme and pathway databases

BioCyc

SSP1148:SLL1875-MON.

Family and domain databases

InterPro

IPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]

Gene3D

G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.

PANTHER

PTHR10720. Haem_Oase. 1 hit.

Pfam

PF01126. Heme_oxygenase. 1 hit.
[Graphical view]

PIRSF

PIRSF000343. Haem_Oase. 1 hit.

PRINTS

PR00088. HAEMOXYGNASE.

PROSITE

PS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

ProtoNet

Search...

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Entry information

Entry name

HO2_SYNY3

Accession

Primary (citable) accession number: P74133

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names