Reviewed, UniProtKB/Swiss-Prot P74130 (TRE2_SYNY3)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component I-like protein
    EC=4.1.3.27

Gene names

Name:	trpE2
Ordered Locus Names:	slr1979

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.
Caution	This is a divergent form of trpE. It is not obvious if it is active in Trp biosynthesis.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Anthranilate synthase component I-like protein		PRO_0000154115

Sequences

	Sequence		Length	Mass (Da)
	P74130-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 4F25ECCB3897BC7C	FASTA	485	54,271
	10 20 30 40 50 60 MASIAHCSGG LVGAGNFDFI LGGSDPVGRH GLMELQPWHW CCLPLEGRTG SEIFSQLFGH 70 80 90 100 110 120 QGIATLLESP YPASPDHPHL GRYSLCAGQP RKGRLWTPKP EEIFSFLNQL CPCNHDVNLT 130 140 150 160 170 180 KNIPEHLPFH GGWLGWLGYD TAWAIEKLPY SKADDLPFPV AYWYEPENFV ILDHQEQLLW 190 200 210 220 230 240 LATTDQEKIK FFQTQLADKI NSVSSPQVPP LNLTYTTDQD QYETMVNQAK QYIKAGDIFQ 250 260 270 280 290 300 ANLTLRFIAK TEQKLNSWQV YQHLQTINPS PFASYWRSPW GDVVSCSPER LVKLEGNVAQ 310 320 330 340 350 360 TRPIAGTRAR GKNLAEDEQL LQELLVNTKE LAEHIMLVDL ERNDLGRVCT WGTVEVDELL 370 380 390 400 410 420 AIERYSHVSH LVSNVKGILQ PDKTGVDLVK ALFPGGTITG CPKIRCLEII EELEPVRRSL 430 440 450 460 470 480 FYGSCGYWDQ RGNLDLNILI RTLLFTSGQV TGQVGAGIVA DSDPAKEWLE SLQKAKALLA ALEGL

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA18216.1.
PIR	S75655.
RefSeq	NP_441536.1.
3D structure databases
HSSP	HSSP built from PDB template 1K0G based on UniProtKB P05041.
ModBase	Search...
Protein-protein interaction databases
STRING	P74130.
Genome annotation databases
GeneID	951847.
GenomeReviews	Gene locus slr1979 in contig BA000022_GR.
KEGG	syn:slr1979.
NMPDR	fig|1148.1.peg.1637.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P74130.
OMA	DLAWEIE.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1979-MON.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR010118. Para-NH2Bz/anthranilate_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01824. PabB-clade2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRE2_SYNY3

Accession

Primary (citable) accession number: P74130

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	November 3, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)