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Protein

GTPase Der

Gene

der

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GTPase that plays an essential role in the late steps of ribosome biogenesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTP 1UniRule annotation
Nucleotide bindingi57 – 615GTP 1UniRule annotation
Nucleotide bindingi120 – 1234GTP 1UniRule annotation
Nucleotide bindingi183 – 1908GTP 2UniRule annotation
Nucleotide bindingi230 – 2345GTP 2UniRule annotation
Nucleotide bindingi295 – 2984GTP 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase DerUniRule annotation
Alternative name(s):
GTP-binding protein EngAUniRule annotation
Gene namesi
Name:derUniRule annotation
Synonyms:engA
Ordered Locus Names:slr1974
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452GTPase DerPRO_0000179063Add
BLAST

Proteomic databases

PaxDbiP74120.

Interactioni

Subunit structurei

Associates with the 50S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

IntActiP74120. 11 interactions.
STRINGi1148.SYNGTS_1631.

Structurei

3D structure databases

ProteinModelPortaliP74120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 169166EngA-type G 1Add
BLAST
Domaini177 – 352176EngA-type G 2Add
BLAST
Domaini353 – 43987KH-likeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.UniRule annotation
Contains 1 KH-like domain.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1160.
HOGENOMiHOG000242861.
InParanoidiP74120.
KOiK03977.
OMAiPQSYLRY.
OrthoDBiEOG6DC6K1.
PhylomeDBiP74120.

Family and domain databases

Gene3Di3.30.300.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00195. GTPase_Der.
InterProiIPR003593. AAA+_ATPase.
IPR031166. G_ENGA.
IPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamiPF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFiPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. small_GTP. 2 hits.
PROSITEiPS51712. G_ENGA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPIVAIIG RPNVGKSTFV NRLAGNQQAI VHDQPGITRD RTYRPAFWRD
60 70 80 90 100
RDFQVVDTGG LVFNDDSEFL PEIREQANLA LAEAKAAIFV VDGQQGPTAS
110 120 130 140 150
DEEIAQWLRQ QSVPVILAVN KCESPDQGAI QAAEFWHLGL GEPYPMSAIH
160 170 180 190 200
GSGTGDLLDA LLEYLPAPQE EPEEDEIKVA IVGRPNVGKS SLLNALTGEQ
210 220 230 240 250
RAIVSPISGT TRDAIDMVVE RNGQKYRLID TAGIRRKKNV DYGAEFFGIN
260 270 280 290 300
RAFKAIRRAD VVLFVLDVLD GVTEQDLKLA GRIIEDGRAV VLVINKWDAV
310 320 330 340 350
EKDSYTIYEH REQLMARLYF MDWAEMIFVS AQTGLRVQKI LDCVDIAAQE
360 370 380 390 400
HRRRVTTAVI NEVLEEAVSW HSPPTTRQGK QGKIYYGTQV STQPPAIALF
410 420 430 440 450
VNDPNRFNDN YRRYIEKQFR KQLGFFGSPI RLFWRGKKVR EMEGSRNRAT

KV
Length:452
Mass (Da):50,826
Last modified:February 1, 1997 - v1
Checksum:i7FF771EAF7D6CC76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18206.1.
PIRiS75645.
RefSeqiYP_005651584.1. NC_017277.1.
YP_007451408.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18206; BAA18206; BAA18206.
KEGGisyn:slr1974.
PATRICi23840475. VBISynSp132158_1795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18206.1.
PIRiS75645.
RefSeqiYP_005651584.1. NC_017277.1.
YP_007451408.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP74120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP74120. 11 interactions.
STRINGi1148.SYNGTS_1631.

Proteomic databases

PaxDbiP74120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18206; BAA18206; BAA18206.
KEGGisyn:slr1974.
PATRICi23840475. VBISynSp132158_1795.

Phylogenomic databases

eggNOGiCOG1160.
HOGENOMiHOG000242861.
InParanoidiP74120.
KOiK03977.
OMAiPQSYLRY.
OrthoDBiEOG6DC6K1.
PhylomeDBiP74120.

Family and domain databases

Gene3Di3.30.300.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00195. GTPase_Der.
InterProiIPR003593. AAA+_ATPase.
IPR031166. G_ENGA.
IPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamiPF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFiPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. small_GTP. 2 hits.
PROSITEiPS51712. G_ENGA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiDER_SYNY3
AccessioniPrimary (citable) accession number: P74120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: June 24, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.