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P74120 (DER_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase Der
Alternative name(s):
GTP-binding protein EngA
Gene names
Name:der
Synonyms:engA
Ordered Locus Names:slr1974
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP-Rule MF_00195

Subunit structure

Associates with the 50S ribosomal subunit By similarity.

Sequence similarities

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.

Contains 2 EngA-type G (guanine nucleotide-binding) domains.

Contains 1 KH-like domain.

Ontologies

Keywords
   Biological processRibosome biogenesis
   DomainRepeat
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processribosome biogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452GTPase Der HAMAP-Rule MF_00195
PRO_0000179063

Regions

Domain4 – 169166EngA-type G 1
Domain177 – 352176EngA-type G 2
Domain353 – 43987KH-like
Nucleotide binding10 – 178GTP 1 Potential
Nucleotide binding57 – 615GTP 1 Potential
Nucleotide binding120 – 1234GTP 1 Potential
Nucleotide binding183 – 1908GTP 2 Potential
Nucleotide binding230 – 2345GTP 2 Potential
Nucleotide binding295 – 2984GTP 2 Potential

Sequences

Sequence LengthMass (Da)Tools
P74120 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 7FF771EAF7D6CC76

FASTA45250,826
        10         20         30         40         50         60 
MSLPIVAIIG RPNVGKSTFV NRLAGNQQAI VHDQPGITRD RTYRPAFWRD RDFQVVDTGG 

        70         80         90        100        110        120 
LVFNDDSEFL PEIREQANLA LAEAKAAIFV VDGQQGPTAS DEEIAQWLRQ QSVPVILAVN 

       130        140        150        160        170        180 
KCESPDQGAI QAAEFWHLGL GEPYPMSAIH GSGTGDLLDA LLEYLPAPQE EPEEDEIKVA 

       190        200        210        220        230        240 
IVGRPNVGKS SLLNALTGEQ RAIVSPISGT TRDAIDMVVE RNGQKYRLID TAGIRRKKNV 

       250        260        270        280        290        300 
DYGAEFFGIN RAFKAIRRAD VVLFVLDVLD GVTEQDLKLA GRIIEDGRAV VLVINKWDAV 

       310        320        330        340        350        360 
EKDSYTIYEH REQLMARLYF MDWAEMIFVS AQTGLRVQKI LDCVDIAAQE HRRRVTTAVI 

       370        380        390        400        410        420 
NEVLEEAVSW HSPPTTRQGK QGKIYYGTQV STQPPAIALF VNDPNRFNDN YRRYIEKQFR 

       430        440        450 
KQLGFFGSPI RLFWRGKKVR EMEGSRNRAT KV 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA18206.1.
PIRS75645.
RefSeqNP_441526.1. NC_000911.1.
YP_005651584.1. NC_017277.1.
YP_007451408.1. NC_020286.1.

3D structure databases

ProteinModelPortalP74120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP74120. 11 interactions.
STRING1148.slr1974.

Proteomic databases

PaxDbP74120.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA18206; BAA18206; BAA18206.
GeneID954938.
KEGGsyn:slr1974.
syy:SYNGTS_1631.
syz:MYO_116460.
PATRIC23840475. VBISynSp132158_1795.

Phylogenomic databases

eggNOGCOG1160.
HOGENOMHOG000242861.
KOK03977.
OMAISVDWDW.
OrthoDBEOG6DC6K1.
PhylomeDBP74120.

Family and domain databases

Gene3D3.30.300.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPMF_00195. GTPase_Der.
InterProIPR003593. AAA+_ATPase.
IPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamPF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSPR00326. GTP1OBG.
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
TIGRFAMsTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. small_GTP. 2 hits.
PROSITEPS51712. G_ENGA. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDER_SYNY3
AccessionPrimary (citable) accession number: P74120
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families