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Protein

Ribulose-phosphate 3-epimerase

Gene

rpe

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Co2+By similarity, Fe2+By similarity, Mn2+By similarity, Zn2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Co2+, Fe2+, Mn2+ and Zn2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateBy similarity1
Metal bindingi35Divalent metal cationBy similarity1
Active sitei37Proton acceptorBy similarity1
Metal bindingi37Divalent metal cationBy similarity1
Metal bindingi68Divalent metal cationBy similarity1
Binding sitei68SubstrateBy similarity1
Active sitei179Proton donorBy similarity1
Metal bindingi179Divalent metal cationBy similarity1
Binding sitei181Substrate; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandCobalt, Iron, Manganese, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase (EC:5.1.3.1)
Alternative name(s):
Pentose-5-phosphate 3-epimerase
Short name:
PPE
R5P3E
Gene namesi
Name:rpe
Ordered Locus Names:sll0807
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001715822 – 230Ribulose-phosphate 3-epimeraseAdd BLAST229

Proteomic databases

PaxDbiP74061
PRIDEiP74061

Interactioni

Subunit structurei

Homohexamer.1 Publication

Protein-protein interaction databases

IntActiP74061, 1 interactor
STRINGi1148.SYNGTS_1562

Structurei

Secondary structure

1230
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 10Combined sources5
Helixi11 – 13Combined sources3
Helixi16 – 18Combined sources3
Helixi19 – 28Combined sources10
Beta strandi32 – 45Combined sources14
Helixi51 – 57Combined sources7
Helixi58 – 60Combined sources3
Beta strandi63 – 73Combined sources11
Helixi74 – 76Combined sources3
Helixi78 – 84Combined sources7
Beta strandi87 – 92Combined sources6
Turni95 – 97Combined sources3
Helixi101 – 110Combined sources10
Beta strandi114 – 119Combined sources6
Helixi125 – 128Combined sources4
Turni129 – 131Combined sources3
Helixi132 – 134Combined sources3
Beta strandi136 – 143Combined sources8
Helixi154 – 156Combined sources3
Helixi157 – 170Combined sources14
Beta strandi175 – 181Combined sources7
Turni184 – 187Combined sources4
Helixi188 – 193Combined sources6
Beta strandi197 – 201Combined sources5
Helixi202 – 205Combined sources4
Helixi210 – 218Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TQJX-ray1.60A/B/C/D/E/F1-230[»]
ProteinModelPortaliP74061
SMRiP74061
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP74061

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni146 – 149Substrate bindingBy similarity4
Regioni201 – 202Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000259348
InParanoidiP74061
KOiK01783
OMAiCHLMIED
PhylomeDBiP74061

Family and domain databases

CDDicd00429 RPE, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR026019 Ribul_P_3_epim
IPR000056 Ribul_P_3_epim-like
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR11749 PTHR11749, 1 hit
PfamiView protein in Pfam
PF00834 Ribul_P_3_epim, 1 hit
PIRSFiPIRSF001461 RPE, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01163 rpe, 1 hit
PROSITEiView protein in PROSITE
PS01085 RIBUL_P_3_EPIMER_1, 1 hit
PS01086 RIBUL_P_3_EPIMER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P74061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNIVVAPS ILSADFSRLG EEIKAVDEAG ADWIHVDVMD GRFVPNITIG
60 70 80 90 100
PLIVDAIRPL TKKTLDVHLM IVEPEKYVED FAKAGADIIS VHVEHNASPH
110 120 130 140 150
LHRTLCQIRE LGKKAGAVLN PSTPLDFLEY VLPVCDLILI MSVNPGFGGQ
160 170 180 190 200
SFIPEVLPKI RALRQMCDER GLDPWIEVDG GLKPNNTWQV LEAGANAIVA
210 220 230
GSAVFNAPNY AEAIAGVRNS KRPEPQLATV
Length:230
Mass (Da):24,971
Last modified:January 23, 2007 - v3
Checksum:i6BE4D0930084B96B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18137.1
PIRiS75576

Genome annotation databases

EnsemblBacteriaiBAA18137; BAA18137; BAA18137
KEGGisyn:sll0807

Similar proteinsi

Entry informationi

Entry nameiRPE_SYNY3
AccessioniPrimary (citable) accession number: P74061
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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