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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K(+)UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961SubstrateUniRule annotation
Active sitei102 – 1021Proton acceptorUniRule annotation
Metal bindingi122 – 1221Monovalent cationUniRule annotation
Binding sitei125 – 1251ATPUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. pantothenate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:slr0812
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Type III pantothenate kinasePRO_0000270905Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiP74045. 1 interaction.
STRINGi1148.slr0812.

Structurei

3D structure databases

ProteinModelPortaliP74045.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni100 – 1034Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1521.
HOGENOMiHOG000066026.
InParanoidiP74045.
KOiK03525.
OMAiFPCLVVD.
OrthoDBiEOG6384HH.
PhylomeDBiP74045.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.

Sequencei

Sequence statusi: Complete.

P74045-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METSKPGCGL ALDNDKQKPW LGLMIGNSRL HWAYCSGNAP LQTWVTDYNP
60 70 80 90 100
KSAQLPVLLG KVPLMLASVV PEQTEVWRVY QPKILTLKNL PLVNLYPSFG
110 120 130 140 150
IDRALAGLGT GLTYGFPCLV VDGGTALTIT GFDQDKKLVG GAILPGLGLQ
160 170 180 190 200
LATLGDRLAA LPKLEMDQLT ELPDRWALDT PSAIFSGVVY GVLGALQSYL
210 220 230 240 250
QDWQKLFPGA AMVITGGDGK ILHGFLKEHS PNLSVAWDDN LIFLGMAAIH

HGDRPIC
Length:257
Mass (Da):27,702
Last modified:February 1, 1997 - v1
Checksum:i4291E51EE91FB4A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18120.1.
PIRiS75559.
RefSeqiNP_441440.1. NC_000911.1.
YP_005651498.1. NC_017277.1.
YP_007451322.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18120; BAA18120; BAA18120.
GeneIDi954799.
KEGGisyn:slr0812.
PATRICi23840285. VBISynSp132158_1702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18120.1.
PIRiS75559.
RefSeqiNP_441440.1. NC_000911.1.
YP_005651498.1. NC_017277.1.
YP_007451322.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP74045.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP74045. 1 interaction.
STRINGi1148.slr0812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18120; BAA18120; BAA18120.
GeneIDi954799.
KEGGisyn:slr0812.
PATRICi23840285. VBISynSp132158_1702.

Phylogenomic databases

eggNOGiCOG1521.
HOGENOMiHOG000066026.
InParanoidiP74045.
KOiK03525.
OMAiFPCLVVD.
OrthoDBiEOG6384HH.
PhylomeDBiP74045.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiCOAX_SYNY3
AccessioniPrimary (citable) accession number: P74045
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.