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P74045 (COAX_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type III pantothenate kinase

EC=2.7.1.33
Alternative name(s):
PanK-III
Pantothenic acid kinase
Gene names
Name:coaX
Ordered Locus Names:slr0812
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis By similarity. HAMAP-Rule MF_01274

Catalytic activity

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP-Rule MF_01274

Cofactor

Monovalent cations By similarity. HAMAP-Rule MF_01274

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP-Rule MF_01274

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01274

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01274.

Sequence similarities

Belongs to the type III pantothenate kinase family.

Ontologies

Keywords
   Biological processCoenzyme A biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcoenzyme A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantothenate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Type III pantothenate kinase HAMAP-Rule MF_01274
PRO_0000270905

Regions

Nucleotide binding24 – 318ATP By similarity
Region100 – 1034Substrate binding By similarity

Sites

Active site1021Proton acceptor Potential
Metal binding1221Monovalent cation Potential
Binding site961Substrate By similarity
Binding site1251ATP Potential
Binding site1801Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P74045 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 4291E51EE91FB4A2

FASTA25727,702
        10         20         30         40         50         60 
METSKPGCGL ALDNDKQKPW LGLMIGNSRL HWAYCSGNAP LQTWVTDYNP KSAQLPVLLG 

        70         80         90        100        110        120 
KVPLMLASVV PEQTEVWRVY QPKILTLKNL PLVNLYPSFG IDRALAGLGT GLTYGFPCLV 

       130        140        150        160        170        180 
VDGGTALTIT GFDQDKKLVG GAILPGLGLQ LATLGDRLAA LPKLEMDQLT ELPDRWALDT 

       190        200        210        220        230        240 
PSAIFSGVVY GVLGALQSYL QDWQKLFPGA AMVITGGDGK ILHGFLKEHS PNLSVAWDDN 

       250 
LIFLGMAAIH HGDRPIC 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA18120.1.
PIRS75559.
RefSeqNP_441440.1. NC_000911.1.
YP_005651498.1. NC_017277.1.
YP_007451322.1. NC_020286.1.

3D structure databases

ProteinModelPortalP74045.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP74045. 1 interaction.
STRING1148.slr0812.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA18120; BAA18120; BAA18120.
GeneID954799.
KEGGsyn:slr0812.
syy:SYNGTS_1545.
syz:MYO_115580.
PATRIC23840285. VBISynSp132158_1702.

Phylogenomic databases

eggNOGCOG1521.
HOGENOMHOG000066026.
KOK03525.
OMAIGNSRLH.
OrthoDBEOG6384HH.
PhylomeDBP74045.

Enzyme and pathway databases

UniPathwayUPA00241; UER00352.

Family and domain databases

HAMAPMF_01274. Pantothen_kinase_3.
InterProIPR004619. Type_III_PanK.
[Graphical view]
PfamPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00671. baf. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOAX_SYNY3
AccessionPrimary (citable) accession number: P74045
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways