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P74045

- COAX_SYNY3

UniProt

P74045 - COAX_SYNY3

Protein

Type III pantothenate kinase

Gene

coaX

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

    Cofactori

    Monovalent cations.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei96 – 961SubstrateUniRule annotation
    Active sitei102 – 1021Proton acceptorUniRule annotation
    Metal bindingi122 – 1221Monovalent cationUniRule annotation
    Binding sitei125 – 1251ATPUniRule annotation
    Binding sitei180 – 1801SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. pantothenate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Coenzyme A biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00241; UER00352.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
    Alternative name(s):
    PanK-IIIUniRule annotation
    Pantothenic acid kinaseUniRule annotation
    Gene namesi
    Name:coaXUniRule annotation
    Ordered Locus Names:slr0812
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Type III pantothenate kinasePRO_0000270905Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    IntActiP74045. 1 interaction.
    STRINGi1148.slr0812.

    Structurei

    3D structure databases

    ProteinModelPortaliP74045.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni100 – 1034Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the type III pantothenate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1521.
    HOGENOMiHOG000066026.
    KOiK03525.
    OMAiIGNSRLH.
    OrthoDBiEOG6384HH.
    PhylomeDBiP74045.

    Family and domain databases

    HAMAPiMF_01274. Pantothen_kinase_3.
    InterProiIPR004619. Type_III_PanK.
    [Graphical view]
    PfamiPF03309. Pan_kinase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00671. baf. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P74045-1 [UniParc]FASTAAdd to Basket

    « Hide

    METSKPGCGL ALDNDKQKPW LGLMIGNSRL HWAYCSGNAP LQTWVTDYNP    50
    KSAQLPVLLG KVPLMLASVV PEQTEVWRVY QPKILTLKNL PLVNLYPSFG 100
    IDRALAGLGT GLTYGFPCLV VDGGTALTIT GFDQDKKLVG GAILPGLGLQ 150
    LATLGDRLAA LPKLEMDQLT ELPDRWALDT PSAIFSGVVY GVLGALQSYL 200
    QDWQKLFPGA AMVITGGDGK ILHGFLKEHS PNLSVAWDDN LIFLGMAAIH 250
    HGDRPIC 257
    Length:257
    Mass (Da):27,702
    Last modified:February 1, 1997 - v1
    Checksum:i4291E51EE91FB4A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18120.1.
    PIRiS75559.
    RefSeqiNP_441440.1. NC_000911.1.
    YP_005651498.1. NC_017277.1.
    YP_007451322.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18120; BAA18120; BAA18120.
    GeneIDi954799.
    KEGGisyn:slr0812.
    syy:SYNGTS_1545.
    syz:MYO_115580.
    PATRICi23840285. VBISynSp132158_1702.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18120.1 .
    PIRi S75559.
    RefSeqi NP_441440.1. NC_000911.1.
    YP_005651498.1. NC_017277.1.
    YP_007451322.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P74045.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P74045. 1 interaction.
    STRINGi 1148.slr0812.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18120 ; BAA18120 ; BAA18120 .
    GeneIDi 954799.
    KEGGi syn:slr0812.
    syy:SYNGTS_1545.
    syz:MYO_115580.
    PATRICi 23840285. VBISynSp132158_1702.

    Phylogenomic databases

    eggNOGi COG1521.
    HOGENOMi HOG000066026.
    KOi K03525.
    OMAi IGNSRLH.
    OrthoDBi EOG6384HH.
    PhylomeDBi P74045.

    Enzyme and pathway databases

    UniPathwayi UPA00241 ; UER00352 .

    Family and domain databases

    HAMAPi MF_01274. Pantothen_kinase_3.
    InterProi IPR004619. Type_III_PanK.
    [Graphical view ]
    Pfami PF03309. Pan_kinase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00671. baf. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiCOAX_SYNY3
    AccessioniPrimary (citable) accession number: P74045
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3