P74045 (COAX_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type III pantothenate kinase
EC=2.7.1.33

Alternative name(s):
PanK-III
Pantothenic acid kinase

Gene names

Name:	coaX
Ordered Locus Names:	slr0812

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis By similarity. HAMAP-Rule MF_01274
Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP-Rule MF_01274
Cofactor	Monovalent cations By similarity. HAMAP-Rule MF_01274
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP-Rule MF_01274
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01274
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01274.
Sequence similarities	Belongs to the type III pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Type III pantothenate kinase HAMAP-Rule MF_01274		PRO_0000270905
Regions
	Nucleotide binding	24 – 31	8	ATP By similarity
	Region	100 – 103	4	Substrate binding By similarity
Sites
	Active site	102	1	Proton acceptor Potential
	Metal binding	122	1	Monovalent cation Potential
	Binding site	96	1	Substrate By similarity
	Binding site	125	1	ATP Potential
	Binding site	180	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P74045 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 4291E51EE91FB4A2	FASTA	257	27,702
	10 20 30 40 50 60 METSKPGCGL ALDNDKQKPW LGLMIGNSRL HWAYCSGNAP LQTWVTDYNP KSAQLPVLLG 70 80 90 100 110 120 KVPLMLASVV PEQTEVWRVY QPKILTLKNL PLVNLYPSFG IDRALAGLGT GLTYGFPCLV 130 140 150 160 170 180 VDGGTALTIT GFDQDKKLVG GAILPGLGLQ LATLGDRLAA LPKLEMDQLT ELPDRWALDT 190 200 210 220 230 240 PSAIFSGVVY GVLGALQSYL QDWQKLFPGA AMVITGGDGK ILHGFLKEHS PNLSVAWDDN 250 LIFLGMAAIH HGDRPIC

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA18120.1.
PIR	S75559.
RefSeq	NP_441440.1. NC_000911.1. YP_005651498.1. NC_017277.1. YP_007451322.1. NC_020286.1.
3D structure databases
ProteinModelPortal	P74045.
ModBase	Search...
Protein-protein interaction databases
IntAct	P74045. 1 interaction.
STRING	1148.slr0812.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA18120; BAA18120; BAA18120.
GeneID	12254148. 14616980. 954799.
KEGG	syn:slr0812. syy:SYNGTS_1545.
PATRIC	23840285. VBISynSp132158_1702.
Phylogenomic databases
eggNOG	COG1521.
HOGENOM	HOG000066026.
KO	K03525.
OMA	IGNSRLH.
ProtClustDB	PRK13331.
Enzyme and pathway databases
UniPathway	UPA00241; UER00352.
Family and domain databases
HAMAP	MF_01274. Pantothen_kinase_3.
InterPro	IPR004619. Type_III_PanK. [Graphical view]
Pfam	PF03309. Pan_kinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00671. baf. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAX_SYNY3

Accession

Primary (citable) accession number: P74045

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program