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P74007

- SPOT_SYNY3

UniProt

P74007 - SPOT_SYNY3

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Protein
Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Gene
spoT, slr1325
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp By similarity.

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Manganese By similarity.

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
  3. metal ion binding Source: InterPro
  4. phosphoric diester hydrolase activity Source: InterPro

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

UniPathwayiUPA00908; UER00886.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
Alternative name(s):
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:spoT
Ordered Locus Names:slr1325
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
PRO_0000166576Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP74007. 3 interactions.
STRINGi1148.slr1325.

Structurei

3D structure databases

ProteinModelPortaliP74007.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 175100HD
Add
BLAST
Domaini685 – 75975ACT
Add
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.
Contains 1 ACT domain.
Contains 1 HD domain.

Phylogenomic databases

eggNOGiCOG0317.
HOGENOMiHOG000018301.
KOiK00951.
K01139.
OMAiRDFADIY.
OrthoDBiEOG6SV551.
PhylomeDBiP74007.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74007-1 [UniParc]FASTAAdd to Basket

« Hide

MNAVAALPTP TIHTTCAQDI HDIELPQWLE DCLQQWQREI EQGQDETTAP    50
HCLICRAFCF AYDLHAQQRR KSGEPYIAHP VAVAGLLRDL GGDEAMIAAG 100
FLHDVVEDTD ISIEQIEALF GEETASLVEG VTKLSKFNFS STTEHQAENF 150
RRMFLAMAKD IRVIVVKLAD RLHNMRTLDA LSPEKQRRIA RETKDIFAPL 200
ANRLGIWRFK WELEDLSFKY LEPDSYRKIQ SLVVEKRGDR ESRLETVKDM 250
LRFRLRDEGI EHFELQGRPK HLYGIYYKMT SQDKAFEEIY DIAALRIIVE 300
SKGECYRALS VVHDVFKPIP GRFKDYIGLP KPNRYQSLHT TVLGLTSRPL 350
EIQIRTEEMH HVAEYGIAAH WKYKESGGSE NATLTSTDEK FTWLRQLLDW 400
QSDLKDAQEY VENLKQNLFD DDVYVFTPKG EVISLARGAT PVDFAYRIHT 450
EVGHHMKGAR VNGQWLGVDT RLKNGDIVEI VTQKNSHPSL DWLNFVVTPS 500
ARHRIRQWFK RSRRDENILR GRELLEKELG KTGLEALLKS EPMQKTAERC 550
NYQNVEDLLA GLGYGEITSN SVVNRLRENN VNNVKNSQSS QEVTLASSPQ 600
VHPPTPPATG KDNSPIAGIE GLLYHIAGCC HPLPGEPIMG VVTRGARGIS 650
IHRQGCHNLE QMDGDRLIPV RWNPNTNNHQ TYPVDIVIEA IDRVGVLKDI 700
LSRLSDNHIN VRNADVKTHL GRPAIISLKI DIHDYQQLLG IMAKIKNMSD 750
VMDLRRVISG 760
Length:760
Mass (Da):86,569
Last modified:February 1, 1997 - v1
Checksum:iCA276EA2286358F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18078.1.
PIRiS75517.
RefSeqiNP_441398.1. NC_000911.1.
YP_005651456.1. NC_017277.1.
YP_007451280.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18078; BAA18078; BAA18078.
GeneIDi954753.
KEGGisyn:slr1325.
syy:SYNGTS_1503.
syz:MYO_115160.
PATRICi23840191. VBISynSp132158_1655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18078.1 .
PIRi S75517.
RefSeqi NP_441398.1. NC_000911.1.
YP_005651456.1. NC_017277.1.
YP_007451280.1. NC_020286.1.

3D structure databases

ProteinModelPortali P74007.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P74007. 3 interactions.
STRINGi 1148.slr1325.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18078 ; BAA18078 ; BAA18078 .
GeneIDi 954753.
KEGGi syn:slr1325.
syy:SYNGTS_1503.
syz:MYO_115160.
PATRICi 23840191. VBISynSp132158_1655.

Phylogenomic databases

eggNOGi COG0317.
HOGENOMi HOG000018301.
KOi K00951.
K01139.
OMAi RDFADIY.
OrthoDBi EOG6SV551.
PhylomeDBi P74007.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00886 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiSPOT_SYNY3
AccessioniPrimary (citable) accession number: P74007
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi