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P74007

- SPOT_SYNY3

UniProt

P74007 - SPOT_SYNY3

Protein

Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Gene

spoT

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp By similarity.By similarity

    Catalytic activityi

    Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

    Cofactori

    Manganese.By similarity

    Pathwayi

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
    3. metal ion binding Source: InterPro
    4. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Manganese

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00886.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
    Alternative name(s):
    Penta-phosphate guanosine-3'-pyrophosphohydrolase
    Short name:
    (ppGpp)ase
    Gene namesi
    Name:spoT
    Ordered Locus Names:slr1325
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 760760Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolasePRO_0000166576Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiP74007. 3 interactions.
    STRINGi1148.slr1325.

    Structurei

    3D structure databases

    ProteinModelPortaliP74007.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini76 – 175100HDAdd
    BLAST
    Domaini685 – 75975ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated
    Contains 1 ACT domain.PROSITE-ProRule annotation
    Contains 1 HD domain.Curated

    Phylogenomic databases

    eggNOGiCOG0317.
    HOGENOMiHOG000018301.
    KOiK00951.
    K01139.
    OMAiRDFADIY.
    OrthoDBiEOG6SV551.
    PhylomeDBiP74007.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view]
    PfamiPF01842. ACT. 1 hit.
    PF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view]
    SUPFAMiSSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P74007-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAVAALPTP TIHTTCAQDI HDIELPQWLE DCLQQWQREI EQGQDETTAP    50
    HCLICRAFCF AYDLHAQQRR KSGEPYIAHP VAVAGLLRDL GGDEAMIAAG 100
    FLHDVVEDTD ISIEQIEALF GEETASLVEG VTKLSKFNFS STTEHQAENF 150
    RRMFLAMAKD IRVIVVKLAD RLHNMRTLDA LSPEKQRRIA RETKDIFAPL 200
    ANRLGIWRFK WELEDLSFKY LEPDSYRKIQ SLVVEKRGDR ESRLETVKDM 250
    LRFRLRDEGI EHFELQGRPK HLYGIYYKMT SQDKAFEEIY DIAALRIIVE 300
    SKGECYRALS VVHDVFKPIP GRFKDYIGLP KPNRYQSLHT TVLGLTSRPL 350
    EIQIRTEEMH HVAEYGIAAH WKYKESGGSE NATLTSTDEK FTWLRQLLDW 400
    QSDLKDAQEY VENLKQNLFD DDVYVFTPKG EVISLARGAT PVDFAYRIHT 450
    EVGHHMKGAR VNGQWLGVDT RLKNGDIVEI VTQKNSHPSL DWLNFVVTPS 500
    ARHRIRQWFK RSRRDENILR GRELLEKELG KTGLEALLKS EPMQKTAERC 550
    NYQNVEDLLA GLGYGEITSN SVVNRLRENN VNNVKNSQSS QEVTLASSPQ 600
    VHPPTPPATG KDNSPIAGIE GLLYHIAGCC HPLPGEPIMG VVTRGARGIS 650
    IHRQGCHNLE QMDGDRLIPV RWNPNTNNHQ TYPVDIVIEA IDRVGVLKDI 700
    LSRLSDNHIN VRNADVKTHL GRPAIISLKI DIHDYQQLLG IMAKIKNMSD 750
    VMDLRRVISG 760
    Length:760
    Mass (Da):86,569
    Last modified:February 1, 1997 - v1
    Checksum:iCA276EA2286358F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18078.1.
    PIRiS75517.
    RefSeqiNP_441398.1. NC_000911.1.
    YP_005651456.1. NC_017277.1.
    YP_007451280.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18078; BAA18078; BAA18078.
    GeneIDi954753.
    KEGGisyn:slr1325.
    syy:SYNGTS_1503.
    syz:MYO_115160.
    PATRICi23840191. VBISynSp132158_1655.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18078.1 .
    PIRi S75517.
    RefSeqi NP_441398.1. NC_000911.1.
    YP_005651456.1. NC_017277.1.
    YP_007451280.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P74007.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P74007. 3 interactions.
    STRINGi 1148.slr1325.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18078 ; BAA18078 ; BAA18078 .
    GeneIDi 954753.
    KEGGi syn:slr1325.
    syy:SYNGTS_1503.
    syz:MYO_115160.
    PATRICi 23840191. VBISynSp132158_1655.

    Phylogenomic databases

    eggNOGi COG0317.
    HOGENOMi HOG000018301.
    KOi K00951.
    K01139.
    OMAi RDFADIY.
    OrthoDBi EOG6SV551.
    PhylomeDBi P74007.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00886 .

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view ]
    Pfami PF01842. ACT. 1 hit.
    PF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiSPOT_SYNY3
    AccessioniPrimary (citable) accession number: P74007
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3