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P73997 (AROB_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:slr2130
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3613613-dehydroquinate synthase HAMAP MF_00110
PRO_0000140800

Sequences

Sequence LengthMass (Da)Tools
P73997 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: D7EC4CEE741486BC

FASTA36138,855
        10         20         30         40         50         60 
MATTIPVPLP QSPYQVQIVP GGLAAIADHL APLGLGKKIM VVSNPEIYDY YGEVVIQALQ 

        70         80         90        100        110        120 
RAGYEVFQHL IPAGETHKTL ASINELYDVA FQANLERNST LLSLGGGVIG DMTGFGAATW 

       130        140        150        160        170        180 
LRGINFVQVP TSLLAMVDAS IGGKTGVNHP QGKNLIGAFY QPRLVYIDPV VLKTLPEREF 

       190        200        210        220        230        240 
RAGMAEVIKY GVIWDSELFT ALEEAEDLSS IDRLPDELLT KIIQRSCQAK VDVVSQDEKE 

       250        260        270        280        290        300 
AGLRAILNYG HTVGHGVESL TGYGVINHGE AVAIGMEAAA KIAHYLGLCD QSLGDRQRQL 

       310        320        330        340        350        360 
LLKTKLPTEM PPTLAVENLL ASLLHDKKVK AGKVRFILPT AIGQVTISDA VTDEVIKATL 


G

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27184 / PCC 6803 / N-1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000022 Genomic DNA. Translation: BAA18068.1.
PIRS75507.
RefSeqNP_441388.1. NC_000911.1.

3D structure databases

ProteinModelPortalP73997.
ModBaseSearch...

Protein-protein interaction databases

IntActP73997. 5 interactions.
STRINGP73997.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID954743.
GenomeReviewsGene locus slr2130 in contig BA000022_GR.
KEGGsyn:slr2130.
NMPDRfig|1148.1.peg.1489.
PATRIC23840167. VBISynSp132158_1643.

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBP73997.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycSSP1148:SLR2130-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_SYNY3
AccessionPrimary (citable) accession number: P73997
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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