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P73955

- NADK2_SYNY3

UniProt

P73955 - NADK2_SYNY3

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Protein

NAD kinase 2

Gene

nadK2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton acceptorUniRule annotation
Binding sitei160 – 1601NADUniRule annotation
Binding sitei181 – 1811NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 682NADUniRule annotation
Nucleotide bindingi149 – 1502NADUniRule annotation
Nucleotide bindingi192 – 1976NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:sll1415
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307NAD kinase 2PRO_0000120679Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1148.sll1415.

Structurei

3D structure databases

ProteinModelPortaliP73955.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
InParanoidiP73955.
KOiK00858.
OMAiKLHWAGS.
OrthoDBiEOG6PZXDR.
PhylomeDBiP73955.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

P73955-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELKQVIIAH KAGHNESKTY AERCARELEA RGCKVLMGPS GIKDNPYPVF
60 70 80 90 100
LASATEKIDL ALVLGGDGTT LAAARHLSPE GIPILSVNVG GHLGFLTEPF
110 120 130 140 150
DVFQDTQKVW DRLNQDRYAV SQRMMLAASL FEGDRRDPQM VGETYYCLNE
160 170 180 190 200
MCIKPASIDR MPTAIIEVEV DGELIDQYQC DGLLVATPTG STCYTSSANG
210 220 230 240 250
PILHPGMDAI VITPICPLSL SSRPIVIPPG SSVNIWPLGD FELNTKLWTD
260 270 280 290 300
GSLATGVWPG QRVGVWMAHR AAQFILLRES YSFYKTLRDK LQWAGARFLY

DGNNKVN
Length:307
Mass (Da):33,776
Last modified:February 1, 1997 - v1
Checksum:i64EA0964EE45F4EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18022.1.
PIRiS75461.
RefSeqiNP_441342.1. NC_000911.1.
YP_005651399.1. NC_017277.1.
YP_007451224.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18022; BAA18022; BAA18022.
GeneIDi954689.
KEGGisyn:sll1415.
PATRICi23840058. VBISynSp132158_1589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18022.1 .
PIRi S75461.
RefSeqi NP_441342.1. NC_000911.1.
YP_005651399.1. NC_017277.1.
YP_007451224.1. NC_020286.1.

3D structure databases

ProteinModelPortali P73955.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.sll1415.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18022 ; BAA18022 ; BAA18022 .
GeneIDi 954689.
KEGGi syn:sll1415.
PATRICi 23840058. VBISynSp132158_1589.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
InParanoidi P73955.
KOi K00858.
OMAi KLHWAGS.
OrthoDBi EOG6PZXDR.
PhylomeDBi P73955.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiNADK2_SYNY3
AccessioniPrimary (citable) accession number: P73955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3