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Protein

Putative serine protease HhoB

Gene

hhoB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

A putative protease, its function overlaps that of the related putative proteases HtrA and HhoA.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS01.482.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine protease HhoB
Gene namesi
Name:hhoB
Ordered Locus Names:sll1427
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

No effect in a single knockout, but growth is inhibited at high light (120 µmol photons/m2/s) or at elevated temperature in a triple protease knockout mutant (hhoA, hhoB and htrA). Triple mutants are not phototactic. No effect on the PSII repair cycle, even in the triple protease knockout strain.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 416391Putative serine protease HhoBPRO_0000400423Add
BLAST

Expressioni

Inductioni

No induction by UV-B light.1 Publication

Interactioni

Protein-protein interaction databases

IntActiP73940. 15 interactions.

Structurei

3D structure databases

ProteinModelPortaliP73940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini320 – 39879PDZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000223641.
InParanoidiP73940.
OMAiPFERTER.
OrthoDBiEOG61ZTDN.
PhylomeDBiP73940.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P73940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIHLKASHL GVAVLLLLFG GAIGAAGGGY LLSSGQNHSS PDSPVNTSPQ
60 70 80 90 100
SLTPAPVESN YRSALPLTLP RSAQDDQELN FIARAVQKIG PAVVRIDSER
110 120 130 140 150
TAVSQGGPMG DQPFFRRFFG EEMPPNPDPR EQGTGSGFIL SSDGEVLTNA
160 170 180 190 200
HVVEGASTVK VTLKDGSVLE GKVMGIDTMT DVAVVKVEAE NLPVVEIGQS
210 220 230 240 250
DRLQPGEWAI AIGNPLGLDN TVTVGIISAL GRSSSEVGVP DKRVRFIQTD
260 270 280 290 300
AAINPGNSGG PLLNAKGEVI GVNTAIRADA QGLGFAIPIQ TAQNVAENLF
310 320 330 340 350
TKGKMEHPYL GIHMVTLTPE MTKQLRTSGE LPAGVTADTG VLIIQVSPGS
360 370 380 390 400
PAAQAGLAPG DIILEVGGMG VKTATDVQER VEVSQIGEPL AIAVKRGQKP
410
QMMAVRPGPF PEDLGQ
Length:416
Mass (Da):43,196
Last modified:February 1, 1997 - v1
Checksum:iDD32BB997CC6B25B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18006.1.
PIRiS75445.

Genome annotation databases

EnsemblBacteriaiBAA18006; BAA18006; BAA18006.
KEGGisyn:sll1427.
PATRICi23840020. VBISynSp132158_1570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18006.1.
PIRiS75445.

3D structure databases

ProteinModelPortaliP73940.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP73940. 15 interactions.

Protein family/group databases

MEROPSiS01.482.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18006; BAA18006; BAA18006.
KEGGisyn:sll1427.
PATRICi23840020. VBISynSp132158_1570.

Phylogenomic databases

HOGENOMiHOG000223641.
InParanoidiP73940.
OMAiPFERTER.
OrthoDBiEOG61ZTDN.
PhylomeDBiP73940.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  2. "The deg proteases protect Synechocystis sp. PCC 6803 during heat and light stresses but are not essential for removal of damaged D1 protein during the photosystem two repair cycle."
    Barker M., de Vries R., Nield J., Komenda J., Nixon P.J.
    J. Biol. Chem. 281:30347-30355(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOTOPROTECTION, PROTECTION AGAINST HEAT STRESS, DISRUPTION PHENOTYPE.
  3. "The role of the FtsH and Deg proteases in the repair of UV-B radiation-damaged Photosystem II in the cyanobacterium Synechocystis PCC 6803."
    Cheregi O., Sicora C., Kos P.B., Barker M., Nixon P.J., Vass I.
    Biochim. Biophys. Acta 1767:820-828(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiHHOB_SYNY3
AccessioniPrimary (citable) accession number: P73940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: February 1, 1997
Last modified: March 16, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.