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Protein

Coenzyme A biosynthesis bifunctional protein CoaBC

Gene

coaBC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine (By similarity).By similarity

Catalytic activityi

N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.
CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine.

Cofactori

FMNBy similarityNote: Binds 1 FMN per subunit.By similarity

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei125SubstrateBy similarity1
Active sitei159Proton donorBy similarity1
Binding sitei283CTPBy similarity1
Binding sitei293CTPBy similarity1
Binding sitei342CTPBy similarity1
Binding sitei346CTPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Ligase, Lyase
LigandFlavoprotein, FMN

Enzyme and pathway databases

UniPathwayiUPA00241; UER00353.
UPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis bifunctional protein CoaBC
Alternative name(s):
DNA/pantothenate metabolism flavoprotein
Including the following 2 domains:
Phosphopantothenoylcysteine decarboxylase (EC:4.1.1.36)
Short name:
PPCDC
Alternative name(s):
CoaC
Phosphopantothenate--cysteine ligase (EC:6.3.2.5)
Alternative name(s):
CoaB
PPC synthetase
Short name:
PPCS
Phosphopantothenoylcysteine synthase
Gene namesi
Name:coaBC
Synonyms:dfp
Ordered Locus Names:sll0250
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002326971 – 402Coenzyme A biosynthesis bifunctional protein CoaBCAdd BLAST402

Proteomic databases

PRIDEiP73881.

Interactioni

Subunit structurei

Homododecamer, the CoaB domains form homodimers.

Protein-protein interaction databases

STRINGi1148.SYNGTS_1368.

Structurei

3D structure databases

ProteinModelPortaliP73881.
SMRiP73881.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 191Phosphopantothenoylcysteine decarboxylaseAdd BLAST191
Regioni192 – 402Phosphopantothenate--cysteine ligaseAdd BLAST211

Sequence similaritiesi

In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.Curated
In the C-terminal section; belongs to the PPC synthetase family.Curated

Phylogenomic databases

HOGENOMiHOG000037526.
InParanoidiP73881.
KOiK13038.
OMAiVRFIGNH.
PhylomeDBiP73881.

Family and domain databases

Gene3Di3.40.50.10300. 1 hit.
3.40.50.1950. 1 hit.
InterProiView protein in InterPro
IPR035929. CoaB-like_sf.
IPR005252. CoaBC.
IPR007085. DNA/pantothenate-metab_flavo_C.
IPR036551. Flavin_trans-like.
IPR003382. Flavoprotein.
PfamiView protein in Pfam
PF04127. DFP. 1 hit.
PF02441. Flavoprotein. 1 hit.
SUPFAMiSSF102645. SSF102645. 1 hit.
SSF52507. SSF52507. 1 hit.
TIGRFAMsiTIGR00521. coaBC_dfp. 1 hit.

Sequencei

Sequence statusi: Complete.

P73881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKGKRILIG VGGGIAAYKI CEVVSQLFQQ GAEVRVILTA EAEKFVTPLT
60 70 80 90 100
FTTLARHPAY GDADFWQPIH HRPLHIDLGE WADIFLIAPL TAHTLAKLGH
110 120 130 140 150
GFADDLLSNT VLASSCPILL APAMNTDMWE QEAVQRNLQQ LLGDRRYHLL
160 170 180 190 200
APNGGLLACD RRGVGRLAEP AQIMHRLQAL LFTGGQEDLR GKRILITAGG
210 220 230 240 250
TQEYLDAVRF IGNPSTGKMG LALAQSAGDR GARVTLIHGP IGDLPIPMGV
260 270 280 290 300
ISMAVVNAEQ MEQALAQQAP LADWIVMAAA VADVKPAQTW TGKIAKQDLP
310 320 330 340 350
DSLPLAPVPD LIAQVSKQKR PHQLLVGFAA QAGDIVTPAK EKLQRKNLDV
360 370 380 390 400
IVANPIDQPQ SGFGTDSNQA VIIDRHGSQT AIAPCSKLAM AHRIWQYLLE

RI
Length:402
Mass (Da):43,419
Last modified:February 1, 1997 - v1
Checksum:i7E3F73DE185EC97C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17944.1.
PIRiS75082.

Genome annotation databases

EnsemblBacteriaiBAA17944; BAA17944; BAA17944.
KEGGisyn:sll0250.

Similar proteinsi

Entry informationi

Entry nameiCOABC_SYNY3
AccessioniPrimary (citable) accession number: P73881
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 25, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names