P73826 (FABG2_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase 2
EC=1.1.1.100

Alternative name(s):
3-ketoacyl-acyl carrier protein reductase 2

Gene names

Name:	fabG2
Ordered Locus Names:	slr1994

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	3-oxoacyl-[acyl-carrier-protein] reductase 2		PRO_0000054692
Regions
	Nucleotide binding	13 – 37	25	NADP By similarity
Sites
	Active site	147	1	Proton acceptor By similarity
	Binding site	134	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P73826 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 7C2F8A33C434645F	FASTA	240	25,333
	10 20 30 40 50 60 MLSLGLEDKV IVVTGGNRGI GAAIVKLLQE MGAKVAFTDL ATDGGNTEAL GVVANVTDLE 70 80 90 100 110 120 SMTAAAAEIT DKLGPVYGVV ANAGITKDNF FPKLTPADWD AVLNVNLKGV AYSIKPFIEG 130 140 150 160 170 180 MYERKAGSIV AISSISGERG NVGQTNYSAT KAGVIGMMKS LAREGARYGV RANAVAPGFI 190 200 210 220 230 240 DTEMTLAIRE DIREKITKEI PFRRFGKPEE IAWAVAFLLS PVASSYVTGE VLRVNGAHHT

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA17883.1.
PIR	S75021.
RefSeq	NP_441203.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P73826.
ModBase	Search...
Protein-protein interaction databases
STRING	P73826.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	954542.
GenomeReviews	Gene locus slr1994 in contig BA000022_GR.
KEGG	syn:slr1994.
NMPDR	fig|1148.1.peg.1304.
PATRIC	23839731. VBISynSp132158_1427.
Phylogenomic databases
eggNOG	COG1028.
HOGENOM	HBG750976.
PhylomeDB	P73826.
ProtClustDB	CLSK893033.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1994-MONOMER.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00059.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG2_SYNY3

Accession

Primary (citable) accession number: P73826

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program