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Protein

3-oxoacyl-[acyl-carrier-protein] reductase 2

Gene

fabG2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei134SubstrateBy similarity1
Active sitei147Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 37NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase 2 (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase 2
Gene namesi
Name:fabG2
Ordered Locus Names:slr1994
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546921 – 2403-oxoacyl-[acyl-carrier-protein] reductase 2Add BLAST240

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni5 – 8Combined sources4
Beta strandi10 – 14Combined sources5
Helixi19 – 29Combined sources11
Turni30 – 32Combined sources3
Beta strandi34 – 40Combined sources7
Beta strandi51 – 53Combined sources3
Helixi59 – 73Combined sources15
Beta strandi78 – 81Combined sources4
Helixi91 – 93Combined sources3
Helixi96 – 106Combined sources11
Helixi108 – 124Combined sources17
Beta strandi127 – 132Combined sources6
Helixi135 – 139Combined sources5
Helixi145 – 165Combined sources21
Helixi166 – 168Combined sources3
Beta strandi170 – 177Combined sources8
Helixi185 – 187Combined sources3
Helixi190 – 197Combined sources8
Helixi208 – 219Combined sources12
Turni221 – 223Combined sources3
Beta strandi231 – 235Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RZIX-ray2.89A/B/C1-240[»]
ProteinModelPortaliP73826.
SMRiP73826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP73826.
KOiK00059.
OMAiNTHFPEC.
PhylomeDBiP73826.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLGLEDKV IVVTGGNRGI GAAIVKLLQE MGAKVAFTDL ATDGGNTEAL
60 70 80 90 100
GVVANVTDLE SMTAAAAEIT DKLGPVYGVV ANAGITKDNF FPKLTPADWD
110 120 130 140 150
AVLNVNLKGV AYSIKPFIEG MYERKAGSIV AISSISGERG NVGQTNYSAT
160 170 180 190 200
KAGVIGMMKS LAREGARYGV RANAVAPGFI DTEMTLAIRE DIREKITKEI
210 220 230 240
PFRRFGKPEE IAWAVAFLLS PVASSYVTGE VLRVNGAHHT
Length:240
Mass (Da):25,333
Last modified:February 1, 1997 - v1
Checksum:i7C2F8A33C434645F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17883.1.
PIRiS75021.

Genome annotation databases

EnsemblBacteriaiBAA17883; BAA17883; BAA17883.
KEGGisyn:slr1994.
PATRICi23839731. VBISynSp132158_1427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17883.1.
PIRiS75021.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RZIX-ray2.89A/B/C1-240[»]
ProteinModelPortaliP73826.
SMRiP73826.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17883; BAA17883; BAA17883.
KEGGisyn:slr1994.
PATRICi23839731. VBISynSp132158_1427.

Phylogenomic databases

InParanoidiP73826.
KOiK00059.
OMAiNTHFPEC.
PhylomeDBiP73826.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABG2_SYNY3
AccessioniPrimary (citable) accession number: P73826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.