Reviewed, UniProtKB/Swiss-Prot P73821 (SERA_SYNY3)

Names and origin

Protein names

Recommended name:
    D-3-phosphoglycerate dehydrogenase
      Short name=PGDH
    EC=1.1.1.95

Gene names

Name:	serA
Ordered Locus Names:	sll1908

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	554 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH. 2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH.
Pathway	Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glyceric acid: step 1/3.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Contains 1 ACT domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Serine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro amino acid binding Inferred from electronic annotation. Source: InterPro phosphoglycerate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 554	554	D-3-phosphoglycerate dehydrogenase		PRO_0000076007
Regions
	Domain	481 – 552	72	ACT
Sites
	Active site	258	1	By similarity
	Active site	287	1	By similarity
	Active site	305	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P73821-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 1D25DCDE7A8DB1D9	FASTA	554	59,222
	10 20 30 40 50 60 MNLAWLQGLS LGLLSPPAPA LLIFRSFTMA KVLVSDSIDQ VGIDILKQVA QVDVKTGLSE 70 80 90 100 110 120 AEIIDIVPEY DAIMLRSATK VTEKIIQAGS QLKIIGRAGV GVDNIDVPAA TRQGIVVVNS 130 140 150 160 170 180 PEGNTIAAAE HALAMMMALA RHIPDANKSV KESKWERKQF IGTEVYKKTL GVVGLGKIGS 190 200 210 220 230 240 HVAGVAKAMG MKLLAYDPFI SQERADQIGC TLVDLDLLFS EADFITLHIP KTPETANLIN 250 260 270 280 290 300 AETLAKMKPT ARIINCSRGG IIDEEALVTA IETAQIGGAA LDVFAQEPLG ESRLREFSNV 310 320 330 340 350 360 ILTPHLGAST EEAQVNVAVD VAEQIRDVLL GLPARSAVNI PGLTPDVMEK LRPYLKLAET 370 380 390 400 410 420 LGTLVGQLAG GRIDRLTVCL QGDLAEYTNS QPLVVAAIKG LLSQALRERV NYVNAAIEAK 430 440 450 460 470 480 ERGIRVIETK DASVRDYSGS LHLKATGTMG EHSATGALLS NGEIRITDVD EFPINVPPNN 490 500 510 520 530 540 YMLFTLHRDM PGIIGKIGSL LGSFNVNIAS MQVGRKIVRG DAIMALSLDD PLPDGLLSEI 550 TKVAGIRDAY TVKL

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA17878.1.
PIR	S75016.
RefSeq	NP_441198.1.
3D structure databases
HSSP	HSSP built from PDB template 1MX3 based on UniProtKB Q13363.
ModBase	Search...
Protein-protein interaction databases
IntAct	P73821. 6 interactions.
Genome annotation databases
GeneID	954536.
GenomeReviews	Gene locus sll1908 in contig BA000022_GR.
KEGG	syn:sll1908.
NMPDR	fig|1148.1.peg.1299.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P73821.
OMA	P73821. DMPGIIG.
Enzyme and pathway databases
BioCyc	SSP1148:SLL1908-MON.
Family and domain databases
InterPro	IPR002912. ACT_bd. IPR006236. D-3-Phosphoglycerate_DH. IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR015508. D3PG_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR10996:SF20. D3PG_Deh. 1 hit.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. PF01842. ACT. 1 hit. [Graphical view]
TIGRFAMs	TIGR01327. PGDH. 1 hit.
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SERA_SYNY3

Accession

Primary (citable) accession number: P73821

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)