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Protein

Aquaporin Z

Gene

aqpZ

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei19 – 191Involved in tetramerization or stability of the tetramerUniRule annotation
Sitei50 – 501Selectivity filterUniRule annotation
Sitei182 – 1821Selectivity filterUniRule annotation
Sitei191 – 1911Selectivity filterUniRule annotation
Sitei197 – 1971Selectivity filterUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin ZUniRule annotation
Gene namesi
Name:aqpZUniRule annotation
Ordered Locus Names:slr2057
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923HelicalUniRule annotationAdd
BLAST
Transmembranei39 – 6123HelicalUniRule annotationAdd
BLAST
Transmembranei88 – 11023HelicalUniRule annotationAdd
BLAST
Transmembranei138 – 16023HelicalUniRule annotationAdd
BLAST
Transmembranei167 – 18923HelicalUniRule annotationAdd
BLAST
Transmembranei209 – 23123HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Aquaporin ZPRO_0000064001Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

IntActiP73809. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP73809.
SMRiP73809. Positions 1-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi70 – 723NPA 1
Motifi194 – 1963NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000288286.
InParanoidiP73809.
KOiK06188.
OMAiYADHSPG.
OrthoDBiEOG6GFGN7.
PhylomeDBiP73809.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z.
InterProiIPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYIAEFIG TFWLVLGGCG SAVFAAFIAA PGGGNTNEFG LGYLGVALAF
60 70 80 90 100
GLTVFTGAYA LGHISGGHFN PAVSFGLWMG KRFPGSQLAP YIGAQVLGAI
110 120 130 140 150
VASLFIFIVA QGGPNFSLDG SNPLATNGFG DHSPQGYGFL AALLIEFVLT
160 170 180 190 200
FIFLIVILGV TDKTAPAGFA PAAIGLALTL IHLISIPITN TSVNPARSTG
210 220 230 240
VALFCGNPAL IGQLWLFWLA PIAGALLAGF VYHNVLEDLG RPEPEAE
Length:247
Mass (Da):25,547
Last modified:February 1, 1997 - v1
Checksum:iED546D1A76D948FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17863.1.
PIRiS74902.

Genome annotation databases

EnsemblBacteriaiBAA17863; BAA17863; BAA17863.
KEGGisyn:slr2057.
PATRICi23839687. VBISynSp132158_1405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17863.1.
PIRiS74902.

3D structure databases

ProteinModelPortaliP73809.
SMRiP73809. Positions 1-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP73809. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17863; BAA17863; BAA17863.
KEGGisyn:slr2057.
PATRICi23839687. VBISynSp132158_1405.

Phylogenomic databases

HOGENOMiHOG000288286.
InParanoidiP73809.
KOiK06188.
OMAiYADHSPG.
OrthoDBiEOG6GFGN7.
PhylomeDBiP73809.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z.
InterProiIPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiAQPZ_SYNY3
AccessioniPrimary (citable) accession number: P73809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.