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P73632 (DDL_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Synonyms:ddlA
Ordered Locus Names:slr1874
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177895

Regions

Domain132 – 342211ATP-grasp
Nucleotide binding168 – 22356ATP By similarity

Sites

Metal binding2951Magnesium or manganese 1 By similarity
Metal binding3091Magnesium or manganese 1 By similarity
Metal binding3091Magnesium or manganese 2 By similarity
Metal binding3111Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P73632 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 871B82362A47315A

FASTA35438,774
        10         20         30         40         50         60 
MRVGLLFGGC SGEHEVSIKS AQAIAKALAS DDNQTKYQVS PFYIQKNGVW LGPDVSQQVL 

        70         80         90        100        110        120 
DQGVPWGDQP VTAGQRWQFP PEAARMEVWF PILHGPNGED GTVQGLFSLM QVPYVGSGVL 

       130        140        150        160        170        180 
GSCVGMDKLA MKMVFERAGL PQVNYMGVER GEIWSNPCVF PALCEKIEAQ VGYPCFVKPA 

       190        200        210        220        230        240 
NLGSSVGIAK VRNRSELEAA LDNAASYDRR IIVEAGLTDI REVECAVLGN ENPQASVVGE 

       250        260        270        280        290        300 
ITYDSDFYDY ETKYTDGRSQ MHIPANLPKA VVNQIQTMAI QAFKAVDAAG LGRLDFFYQP 

       310        320        330        340        350 
TTGQIVINEI NTLPGFTAFS MYPELWRASG VEFPSLVDRL LQLALDYHGR PGHQ 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA17677.1.
PIRS77119.
RefSeqNP_440997.1. NC_000911.1.
YP_005651054.1. NC_017277.1.
YP_007450879.1. NC_020286.1.

3D structure databases

ProteinModelPortalP73632.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP73632. 2 interactions.
STRING1148.slr1874.

Proteomic databases

PaxDbP73632.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17677; BAA17677; BAA17677.
GeneID12255220.
14616533.
954310.
KEGGsyn:slr1874.
syy:SYNGTS_1101.
syz:MYO_111110.
PATRIC23839280. VBISynSp132158_1204.

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
PhylomeDBP73632.
ProtClustDBPRK01966.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_SYNY3
AccessionPrimary (citable) accession number: P73632
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways