P73618 (DEOC_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	sll1776

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_0000057279
Sites
	Active site	156	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	184	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P73618 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: BDF4685A2546F0BA	FASTA	225	23,874
	10 20 30 40 50 60 MEKSRQFDLA PYIDHAALDP ATTREAIATC CAQALHHKFV AVCVYPSALS QAVELLRGKK 70 80 90 100 110 120 VEICAVIGFP SGASTSGSKL YEAQEAAELG ATELDVVINL GLLKDGNTEA VYNDIAPIVE 130 140 150 160 170 180 ATGLTVKAIL EMGRLTESEK RLAAEICLDA GVQYLKTSTG WGKGATVADV RLLHQISQGR 190 200 210 220 VGIKASGGIR TVEQAIALIE AGATRLGTSR GVELIQQQQQ LWEQG

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA17663.1.
PIR	S77105.
RefSeq	NP_440983.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P73618.
ModBase	Search...
Protein-protein interaction databases
STRING	P73618.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	954296.
GenomeReviews	Gene locus sll1776 in contig BA000022_GR.
KEGG	syn:sll1776.
NMPDR	fig|1148.1.peg.1084.
PATRIC	23839242. VBISynSp132158_1185.
Phylogenomic databases
eggNOG	COG0274.
HOGENOM	HBG636421.
OMA	CLEAREN.
PhylomeDB	P73618.
ProtClustDB	PRK00507.
Enzyme and pathway databases
BioCyc	SSP1148:SLL1776-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_SYNY3

Accession

Primary (citable) accession number: P73618

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program