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Protein

UvrABC system protein C

Gene

uvrC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:sll0865
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626UvrABC system protein CPRO_0000138353Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

IntActiP73580. 31 interactions.

Structurei

3D structure databases

ProteinModelPortaliP73580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 10580GIY-YIGUniRule annotationAdd
BLAST
Domaini215 – 25036UVRUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000279960.
InParanoidiP73580.
KOiK03703.
OMAiRCPGVCQ.
PhylomeDBiP73580.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATVSSTSL LEQPELLERR LQEIPQEPGV YFMGDRQGEI LYIGKAKKLR
60 70 80 90 100
TRVRSYFRDS QPHTARIALM VQQVAEIEFI VTDTEAEALA LEANLIKQHQ
110 120 130 140 150
PHFNVLLKDD KKYPYVCITW SETYPRIFIT RKRRLNQAKD RYYGPYVDSF
160 170 180 190 200
SLRQTLRLIQ RIFPLRQRRQ PLFKHRPCLN YDIGRCPGVC QELITPEDYR
210 220 230 240 250
QTLQKVAMVF QGRTQELHQL LTQQMEKAAA DLKFEQAALI RDQINSLGKL
260 270 280 290 300
NADQKVSLPQ DTISRDAIAV ASDGQISAIQ LFQIRAGRLV GRLGFFADGV
310 320 330 340 350
ESELEKGEVL QRVLEQHYQQ VEAVEIPSEV ILPCALPDGE LLNDWLTSQR
360 370 380 390 400
GRKVTFNLPQ RQTKAELLEM VERNAQYELE RLQKQTAKNV TALEDLAEIL
410 420 430 440 450
NLETLPKRIE GYDISHIQGS NAVASQVVFI DGVPAQQYYR HYKIKNPSIK
460 470 480 490 500
VGHSDDFASL AEVIIRRFQS SVKGKKNQQD WPDLIMIDGG KGQLSAVVKV
510 520 530 540 550
LKKMDLLDKF TVVSLAKQRE EIFLPGESQP LPTHAEQPGV QLLRRLRDEA
560 570 580 590 600
HRFAVSFHRQ QRLSKSRRSR LDEIPGLGFS RQKQLLAHFR SLDYIREASV
610 620
KQLQEVPGIG PQLAQTIYDY FHPVNS
Length:626
Mass (Da):71,897
Last modified:February 1, 1997 - v1
Checksum:i9D7E9627F0A645DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17620.1.
PIRiS77286.

Genome annotation databases

EnsemblBacteriaiBAA17620; BAA17620; BAA17620.
KEGGisyn:sll0865.
PATRICi23839152. VBISynSp132158_1140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17620.1.
PIRiS77286.

3D structure databases

ProteinModelPortaliP73580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP73580. 31 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17620; BAA17620; BAA17620.
KEGGisyn:sll0865.
PATRICi23839152. VBISynSp132158_1140.

Phylogenomic databases

HOGENOMiHOG000279960.
InParanoidiP73580.
KOiK03703.
OMAiRCPGVCQ.
PhylomeDBiP73580.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUVRC_SYNY3
AccessioniPrimary (citable) accession number: P73580
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This bacterium is considerably more resistant to UV and gamma irradiation than E.coli; the E.coli-like SOS regulon model is not an appropriate model for DNA repair in this cyanobacterium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.