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Protein

3-oxoacyl-[acyl-carrier-protein] reductase 1

Gene

fabG1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143SubstrateBy similarity1
Active sitei156Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 35NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase 1 (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase 1
Gene namesi
Name:fabG1
Ordered Locus Names:slr0886
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546911 – 2473-oxoacyl-[acyl-carrier-protein] reductase 1Add BLAST247

Interactioni

Protein-protein interaction databases

IntActiP73574. 1 interactor.

Structurei

Secondary structure

1247
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Beta strandi8 – 13Combined sources6
Helixi17 – 28Combined sources12
Beta strandi32 – 39Combined sources8
Helixi41 – 53Combined sources13
Beta strandi57 – 62Combined sources6
Helixi68 – 82Combined sources15
Beta strandi87 – 90Combined sources4
Helixi100 – 102Combined sources3
Helixi105 – 115Combined sources11
Helixi117 – 132Combined sources16
Beta strandi137 – 141Combined sources5
Helixi144 – 148Combined sources5
Helixi154 – 174Combined sources21
Helixi175 – 177Combined sources3
Beta strandi180 – 186Combined sources7
Helixi203 – 205Combined sources3
Helixi214 – 226Combined sources13
Helixi228 – 232Combined sources5
Beta strandi237 – 241Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RZHX-ray2.20A/B1-247[»]
ProteinModelPortaliP73574.
SMRiP73574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP73574.
KOiK00059.
OMAiCTQIANL.
PhylomeDBiP73574.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALTAQVAL VTGASRGIGK ATALALAATG MKVVVNYAQS STAADAVVAE
60 70 80 90 100
IIANGGEAIA VQANVANADE VDQLIKTTLD KFSRIDVLVN NAGITRDTLL
110 120 130 140 150
LRMKLEDWQA VIDLNLTGVF LCTKAVSKLM LKQKSGRIIN ITSVAGMMGN
160 170 180 190 200
PGQANYSAAK AGVIGFTKTV AKELASRGVT VNAVAPGFIA TDMTENLNAE
210 220 230 240
PILQFIPLAR YGQPEEVAGT IRFLATDPAA AYITGQTFNV DGGMVMF
Length:247
Mass (Da):25,724
Last modified:February 1, 1997 - v1
Checksum:i91EBF9409C777F20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17614.1.
PIRiS77280.

Genome annotation databases

EnsemblBacteriaiBAA17614; BAA17614; BAA17614.
KEGGisyn:slr0886.
PATRICi23839140. VBISynSp132158_1134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17614.1.
PIRiS77280.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RZHX-ray2.20A/B1-247[»]
ProteinModelPortaliP73574.
SMRiP73574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP73574. 1 interactor.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17614; BAA17614; BAA17614.
KEGGisyn:slr0886.
PATRICi23839140. VBISynSp132158_1134.

Phylogenomic databases

InParanoidiP73574.
KOiK00059.
OMAiCTQIANL.
PhylomeDBiP73574.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABG1_SYNY3
AccessioniPrimary (citable) accession number: P73574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.