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Protein

3-oxoacyl-[acyl-carrier-protein] reductase 1

Gene

fabG1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateBy similarity
Active sitei156 – 1561Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 3525NADPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase 1 (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase 1
Gene namesi
Name:fabG1
Ordered Locus Names:slr0886
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2472473-oxoacyl-[acyl-carrier-protein] reductase 1PRO_0000054691Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP73574. 1 interaction.

Structurei

Secondary structure

1
247
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 63Combined sources
Beta strandi8 – 136Combined sources
Helixi17 – 2812Combined sources
Beta strandi32 – 398Combined sources
Helixi41 – 5313Combined sources
Beta strandi57 – 626Combined sources
Helixi68 – 8215Combined sources
Beta strandi87 – 904Combined sources
Helixi100 – 1023Combined sources
Helixi105 – 11511Combined sources
Helixi117 – 13216Combined sources
Beta strandi137 – 1415Combined sources
Helixi144 – 1485Combined sources
Helixi154 – 17421Combined sources
Helixi175 – 1773Combined sources
Beta strandi180 – 1867Combined sources
Helixi203 – 2053Combined sources
Helixi214 – 22613Combined sources
Helixi228 – 2325Combined sources
Beta strandi237 – 2415Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RZHX-ray2.20A/B1-247[»]
ProteinModelPortaliP73574.
SMRiP73574. Positions 4-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP73574.
OMAiCTQIANL.
OrthoDBiEOG6N3CR8.
PhylomeDBiP73574.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALTAQVAL VTGASRGIGK ATALALAATG MKVVVNYAQS STAADAVVAE
60 70 80 90 100
IIANGGEAIA VQANVANADE VDQLIKTTLD KFSRIDVLVN NAGITRDTLL
110 120 130 140 150
LRMKLEDWQA VIDLNLTGVF LCTKAVSKLM LKQKSGRIIN ITSVAGMMGN
160 170 180 190 200
PGQANYSAAK AGVIGFTKTV AKELASRGVT VNAVAPGFIA TDMTENLNAE
210 220 230 240
PILQFIPLAR YGQPEEVAGT IRFLATDPAA AYITGQTFNV DGGMVMF
Length:247
Mass (Da):25,724
Last modified:February 1, 1997 - v1
Checksum:i91EBF9409C777F20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17614.1.
PIRiS77280.

Genome annotation databases

EnsemblBacteriaiBAA17614; BAA17614; BAA17614.
PATRICi23839140. VBISynSp132158_1134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17614.1.
PIRiS77280.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RZHX-ray2.20A/B1-247[»]
ProteinModelPortaliP73574.
SMRiP73574. Positions 4-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP73574. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17614; BAA17614; BAA17614.
PATRICi23839140. VBISynSp132158_1134.

Phylogenomic databases

InParanoidiP73574.
OMAiCTQIANL.
OrthoDBiEOG6N3CR8.
PhylomeDBiP73574.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiFABG1_SYNY3
AccessioniPrimary (citable) accession number: P73574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.