P73548 (CDSA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:	cdsA
Ordered Locus Names:	slr1369

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Phosphatidate cytidylyltransferase		PRO_0000090757
Regions
	Transmembrane	6 – 26	21	Helical; Potential
	Transmembrane	51 – 71	21	Helical; Potential
	Transmembrane	73 – 93	21	Helical; Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Transmembrane	157 – 177	21	Helical; Potential
	Transmembrane	195 – 215	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	273 – 293	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P73548 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: A7E3ABC9C17475D0	FASTA	293	31,876
	10 20 30 40 50 60 MPTQRIISAV IGIALAFSLL ILGGWYFSAA IALVIYLGLR EYFQMVRAKG IAPAAKTTMV 70 80 90 100 110 120 LSLMLLLSAT VTPHLTDAFF PLTGALICFY LLFQPKMATI ADISTSLLGL FYGGYLPSYW 130 140 150 160 170 180 VRLRLGDGAV NPMGLHLPLN GFWPESWAHP ENFPTGLLVT ILAFACIWAA DIGAYIMGKW 190 200 210 220 230 240 LGRTRLSDIS PKKTVEGSLW GVGGSLLVGV LGAWYLQWPY WEITGALLGL LIGIVSLLGD 250 260 270 280 290 LTESMMKRDA GVKDSGQLIP GHGGILDRTD SYVFTAPLVY YFVVLLLPVL NNL

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA17588.1.
PIR	S77254.
RefSeq	NP_440908.1. NC_000911.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P73548. 4 interactions.
STRING	P73548.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	954211.
GenomeReviews	Gene locus slr1369 in contig BA000022_GR.
KEGG	syn:slr1369.
NMPDR	fig|1148.1.peg.1009.
PATRIC	23839080. VBISynSp132158_1104.
Phylogenomic databases
eggNOG	COG0575.
HOGENOM	HBG732679.
OMA	ESMMKRD.
PhylomeDB	P73548.
ProtClustDB	CLSK892901.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1369-MONOMER.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
KO	K00981.
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_SYNY3

Accession

Primary (citable) accession number: P73548

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program