Reviewed, UniProtKB/Swiss-Prot P73548 (CDSA_SYNY3)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	slr1369

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Phosphatidate cytidylyltransferase		PRO_0000090757
Regions
	Transmembrane	6 – 26	21	Potential
	Transmembrane	51 – 71	21	Potential
	Transmembrane	73 – 93	21	Potential
	Transmembrane	97 – 117	21	Potential
	Transmembrane	157 – 177	21	Potential
	Transmembrane	195 – 215	21	Potential
	Transmembrane	218 – 238	21	Potential
	Transmembrane	273 – 293	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P73548-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: A7E3ABC9C17475D0	FASTA	293	31,876
	10 20 30 40 50 60 MPTQRIISAV IGIALAFSLL ILGGWYFSAA IALVIYLGLR EYFQMVRAKG IAPAAKTTMV 70 80 90 100 110 120 LSLMLLLSAT VTPHLTDAFF PLTGALICFY LLFQPKMATI ADISTSLLGL FYGGYLPSYW 130 140 150 160 170 180 VRLRLGDGAV NPMGLHLPLN GFWPESWAHP ENFPTGLLVT ILAFACIWAA DIGAYIMGKW 190 200 210 220 230 240 LGRTRLSDIS PKKTVEGSLW GVGGSLLVGV LGAWYLQWPY WEITGALLGL LIGIVSLLGD 250 260 270 280 290 LTESMMKRDA GVKDSGQLIP GHGGILDRTD SYVFTAPLVY YFVVLLLPVL NNL

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA17588.1.
PIR	S77254.
RefSeq	NP_440908.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P73548. 4 interactions.
STRING	P73548.
Genome annotation databases
GeneID	954211.
GenomeReviews	Gene locus slr1369 in contig BA000022_GR.
KEGG	syn:slr1369.
NMPDR	fig|1148.1.peg.1009.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P73548.
OMA	DSGQLIP.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1369-MON.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_SYNY3

Accession

Primary (citable) accession number: P73548

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)