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P73534 (KPYK2_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase 2

Short name=PK 2
EC=2.7.1.40
Gene names
Name:pyk2
Ordered Locus Names:sll1275
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium.

Potassium.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

In the C-terminal section; belongs to the PEP-utilizing enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591Pyruvate kinase 2
PRO_0000112086

Sites

Metal binding401Potassium By similarity
Metal binding421Potassium By similarity
Metal binding721Potassium By similarity
Metal binding2291Magnesium By similarity
Metal binding2531Magnesium By similarity
Binding site381Substrate By similarity
Binding site2521Substrate; via amide nitrogen By similarity
Binding site2531Substrate; via amide nitrogen By similarity
Binding site2851Substrate By similarity
Site2271Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P73534 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 2520AA81145C11EB

FASTA59162,986
        10         20         30         40         50         60 
MQTSPLPRRT KIVATIGPAT QSKEVLRQLI QAGATTFRLN FSHGDHAYHQ QSIRLIRQIA 

        70         80         90        100        110        120 
FELNQPVGIL QDLQGPKIRV GKFLNDAGSV QLKNGDPYTL TSRPVECTET ISSISYEYLA 

       130        140        150        160        170        180 
DEVPSGARIL LDDGKLEMLV EEVDTVARDL HCRVIVGGTL SSNKGVNFPG VCLSVKAMTD 

       190        200        210        220        230        240 
KDKEDLMFGL DQGVDWVALS FVRNPQDIDE IKGLIAAAGK SVPVIAKIEK HEAIKDMQAV 

       250        260        270        280        290        300 
LEKCDGVMVA RGDLGVELPA EDVPILQKKL IATANRLGIP VITATQMLDS MVNSPRPTRA 

       310        320        330        340        350        360 
EVSDVANAIL DGTDAVMLSN ETAIGKFPVE AVAIMAKIAE RIEQEDINPS QAEASRTSIP 

       370        380        390        400        410        420 
NAISSAVSQI AETLNAAAIM SLTKTGSTAR HVSKFRPKTP ILAVTPHVDV SRQLQLVWGV 

       430        440        450        460        470        480 
KPLLVLDLPS TSQTFQAAIN VAQENHFLRD GDLVVMTAGT LQGVAGSTDL IKVEVVKAIL 

       490        500        510        520        530        540 
GRGVGIGQGA VSGRARVASR PQAIAQFTQG EILVVPSTNA DCVDMMRRAA GIITEEESLT 

       550        560        570        580        590 
SHAAIIGLRL GVPVIVGFKG ATQKIRDGAI VTIDAQKGLI YSGALPPVSK G 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA17574.1.
PIRS77240.
RefSeqNP_440894.1. NC_000911.1.
YP_005650953.1. NC_017277.1.
YP_007450777.1. NC_020286.1.

3D structure databases

ProteinModelPortalP73534.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP73534. 2 interactions.
STRING1148.sll1275.

Proteomic databases

PaxDbP73534.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17574; BAA17574; BAA17574.
GeneID12255039.
14616431.
954197.
KEGGsyn:sll1275.
syy:SYNGTS_1000.
syz:MYO_110090.
PATRIC23839046. VBISynSp132158_1087.

Phylogenomic databases

eggNOGCOG0469.
HOGENOMHOG000021558.
KOK00873.
OMAKTHVCSV.
OrthoDBEOG6GBMB0.
PhylomeDBP73534.
ProtClustDBPRK06354.

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
3.50.30.10. 1 hit.
InterProIPR008279. PEP-util_enz_mobile_dom.
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00391. PEP-utilizers. 1 hit.
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52009. SSF52009. 1 hit.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK2_SYNY3
AccessionPrimary (citable) accession number: P73534
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways