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P73534

- KPYK2_SYNY3

UniProt

P73534 - KPYK2_SYNY3

Protein

Pyruvate kinase 2

Gene

pyk2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.
    Potassium.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381SubstrateBy similarity
    Metal bindingi40 – 401PotassiumBy similarity
    Metal bindingi42 – 421PotassiumBy similarity
    Metal bindingi72 – 721PotassiumBy similarity
    Sitei227 – 2271Transition state stabilizerBy similarity
    Metal bindingi229 – 2291MagnesiumBy similarity
    Binding sitei252 – 2521Substrate; via amide nitrogenBy similarity
    Metal bindingi253 – 2531MagnesiumBy similarity
    Binding sitei253 – 2531Substrate; via amide nitrogenBy similarity
    Binding sitei285 – 2851SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase 2 (EC:2.7.1.40)
    Short name:
    PK 2
    Gene namesi
    Name:pyk2
    Ordered Locus Names:sll1275
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591Pyruvate kinase 2PRO_0000112086Add
    BLAST

    Proteomic databases

    PaxDbiP73534.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    IntActiP73534. 2 interactions.
    STRINGi1148.sll1275.

    Structurei

    3D structure databases

    ProteinModelPortaliP73534.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated
    In the C-terminal section; belongs to the PEP-utilizing enzyme family.Curated

    Phylogenomic databases

    eggNOGiCOG0469.
    HOGENOMiHOG000021558.
    KOiK00873.
    OMAiNLTWGVE.
    OrthoDBiEOG6GBMB0.
    PhylomeDBiP73534.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    3.50.30.10. 1 hit.
    InterProiIPR008279. PEP-util_enz_mobile_dom.
    IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00391. PEP-utilizers. 1 hit.
    PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52009. SSF52009. 1 hit.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73534-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTSPLPRRT KIVATIGPAT QSKEVLRQLI QAGATTFRLN FSHGDHAYHQ    50
    QSIRLIRQIA FELNQPVGIL QDLQGPKIRV GKFLNDAGSV QLKNGDPYTL 100
    TSRPVECTET ISSISYEYLA DEVPSGARIL LDDGKLEMLV EEVDTVARDL 150
    HCRVIVGGTL SSNKGVNFPG VCLSVKAMTD KDKEDLMFGL DQGVDWVALS 200
    FVRNPQDIDE IKGLIAAAGK SVPVIAKIEK HEAIKDMQAV LEKCDGVMVA 250
    RGDLGVELPA EDVPILQKKL IATANRLGIP VITATQMLDS MVNSPRPTRA 300
    EVSDVANAIL DGTDAVMLSN ETAIGKFPVE AVAIMAKIAE RIEQEDINPS 350
    QAEASRTSIP NAISSAVSQI AETLNAAAIM SLTKTGSTAR HVSKFRPKTP 400
    ILAVTPHVDV SRQLQLVWGV KPLLVLDLPS TSQTFQAAIN VAQENHFLRD 450
    GDLVVMTAGT LQGVAGSTDL IKVEVVKAIL GRGVGIGQGA VSGRARVASR 500
    PQAIAQFTQG EILVVPSTNA DCVDMMRRAA GIITEEESLT SHAAIIGLRL 550
    GVPVIVGFKG ATQKIRDGAI VTIDAQKGLI YSGALPPVSK G 591
    Length:591
    Mass (Da):62,986
    Last modified:February 1, 1997 - v1
    Checksum:i2520AA81145C11EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17574.1.
    PIRiS77240.
    RefSeqiNP_440894.1. NC_000911.1.
    YP_005650953.1. NC_017277.1.
    YP_007450777.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17574; BAA17574; BAA17574.
    GeneIDi954197.
    KEGGisyn:sll1275.
    syy:SYNGTS_1000.
    syz:MYO_110090.
    PATRICi23839046. VBISynSp132158_1087.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17574.1 .
    PIRi S77240.
    RefSeqi NP_440894.1. NC_000911.1.
    YP_005650953.1. NC_017277.1.
    YP_007450777.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P73534. 2 interactions.
    STRINGi 1148.sll1275.

    Proteomic databases

    PaxDbi P73534.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17574 ; BAA17574 ; BAA17574 .
    GeneIDi 954197.
    KEGGi syn:sll1275.
    syy:SYNGTS_1000.
    syz:MYO_110090.
    PATRICi 23839046. VBISynSp132158_1087.

    Phylogenomic databases

    eggNOGi COG0469.
    HOGENOMi HOG000021558.
    KOi K00873.
    OMAi NLTWGVE.
    OrthoDBi EOG6GBMB0.
    PhylomeDBi P73534.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    3.50.30.10. 1 hit.
    InterProi IPR008279. PEP-util_enz_mobile_dom.
    IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00391. PEP-utilizers. 1 hit.
    PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52009. SSF52009. 1 hit.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiKPYK2_SYNY3
    AccessioniPrimary (citable) accession number: P73534
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3