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Protein

Pyruvate kinase 2

Gene

pyk2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 1 (gap1), Glyceraldehyde-3-phosphate dehydrogenase 2 (gap2)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase 1 (pyk1), Pyruvate kinase 2 (pyk2)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38SubstrateBy similarity1
Metal bindingi40PotassiumBy similarity1
Metal bindingi42PotassiumBy similarity1
Metal bindingi72PotassiumBy similarity1
Sitei227Transition state stabilizerBy similarity1
Metal bindingi229MagnesiumBy similarity1
Binding sitei252Substrate; via amide nitrogenBy similarity1
Metal bindingi253MagnesiumBy similarity1
Binding sitei253Substrate; via amide nitrogenBy similarity1
Binding sitei285SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase 2 (EC:2.7.1.40)
Short name:
PK 2
Gene namesi
Name:pyk2
Ordered Locus Names:sll1275
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001120861 – 591Pyruvate kinase 2Add BLAST591

Proteomic databases

PaxDbiP73534
PRIDEiP73534

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiP73534, 2 interactors
STRINGi1148.SYNGTS_1000

Structurei

3D structure databases

ProteinModelPortaliP73534
SMRiP73534
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated
In the C-terminal section; belongs to the PEP-utilizing enzyme family.Curated

Phylogenomic databases

HOGENOMiHOG000021558
InParanoidiP73534
KOiK00873
OMAiKHEAIEQ
PhylomeDBiP73534

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR008279 PEP-util_enz_mobile_dom
IPR036637 Phosphohistidine_dom_sf
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00391 PEP-utilizers, 1 hit
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52009 SSF52009, 1 hit
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P73534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTSPLPRRT KIVATIGPAT QSKEVLRQLI QAGATTFRLN FSHGDHAYHQ
60 70 80 90 100
QSIRLIRQIA FELNQPVGIL QDLQGPKIRV GKFLNDAGSV QLKNGDPYTL
110 120 130 140 150
TSRPVECTET ISSISYEYLA DEVPSGARIL LDDGKLEMLV EEVDTVARDL
160 170 180 190 200
HCRVIVGGTL SSNKGVNFPG VCLSVKAMTD KDKEDLMFGL DQGVDWVALS
210 220 230 240 250
FVRNPQDIDE IKGLIAAAGK SVPVIAKIEK HEAIKDMQAV LEKCDGVMVA
260 270 280 290 300
RGDLGVELPA EDVPILQKKL IATANRLGIP VITATQMLDS MVNSPRPTRA
310 320 330 340 350
EVSDVANAIL DGTDAVMLSN ETAIGKFPVE AVAIMAKIAE RIEQEDINPS
360 370 380 390 400
QAEASRTSIP NAISSAVSQI AETLNAAAIM SLTKTGSTAR HVSKFRPKTP
410 420 430 440 450
ILAVTPHVDV SRQLQLVWGV KPLLVLDLPS TSQTFQAAIN VAQENHFLRD
460 470 480 490 500
GDLVVMTAGT LQGVAGSTDL IKVEVVKAIL GRGVGIGQGA VSGRARVASR
510 520 530 540 550
PQAIAQFTQG EILVVPSTNA DCVDMMRRAA GIITEEESLT SHAAIIGLRL
560 570 580 590
GVPVIVGFKG ATQKIRDGAI VTIDAQKGLI YSGALPPVSK G
Length:591
Mass (Da):62,986
Last modified:February 1, 1997 - v1
Checksum:i2520AA81145C11EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA17574.1
PIRiS77240

Genome annotation databases

EnsemblBacteriaiBAA17574; BAA17574; BAA17574
KEGGisyn:sll1275

Similar proteinsi

Entry informationi

Entry nameiKPYK2_SYNY3
AccessioniPrimary (citable) accession number: P73534
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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