Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei194 – 1941GTPUniRule annotation
Binding sitei198 – 1981GTPUniRule annotation
Binding sitei242 – 2421GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi76 – 805GTPUniRule annotation
Nucleotide bindingi163 – 1653GTPUniRule annotation

GO - Molecular functioni

  • GTPase activity Source: UniProtKB-HAMAP
  • GTP binding Source: UniProtKB-HAMAP
  • identical protein binding Source: IntAct

GO - Biological processi

  • barrier septum assembly Source: UniProtKB
  • FtsZ-dependent cytokinesis Source: UniProtKB-HAMAP
  • protein polymerization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:sll1633
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Cell division protein FtsZPRO_0000114390Add
BLAST

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-591904,EBI-591904
sll0169Q555592EBI-591904,EBI-591951

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

IntActiP73456. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP73456.
SMRiP73456. Positions 84-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000049094.
InParanoidiP73456.
KOiK03531.
OMAiAQVIWGI.
OrthoDBiEOG6S7XZG.
PhylomeDBiP73456.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNNDLPLN NIGFTGSGLN DGTEGLDDLF SSSIVDNEPL EALVETPTFA
60 70 80 90 100
SPSPNLKRDQ IVPSNIAKIK VIGVGGGGCN AVNRMIASGV TGIDFWAINT
110 120 130 140 150
DSQALTNTNA PDCIQIGQKL TRGLGAGGNP AIGQKAAEES RDEIARSLEG
160 170 180 190 200
TDLVFITAGM GGGTGTGAAP IVAEVAKEMG CLTVGIVTRP FTFEGRRRAK
210 220 230 240 250
QAEEGINALQ SRVDTLIVIP NNQLLSVIPA ETPLQEAFRV ADDILRQGVQ
260 270 280 290 300
GISDIIIIPG LVNVDFADVR AVMADAGSAL MGIGVGSGKS RAKEAATAAI
310 320 330 340 350
SSPLLESSIQ GAKGVVFNVT GGTDLTLHEV NVAAEIIYEV VDADANIIFG
360 370 380 390 400
AVIDDRLQGE MRITVIATGF NGEKEKPQAK TSSKPVLSGP PAGVETVPST
410 420 430
TTPEDPLGEI PMAPELDIPD FLQKRRFPRR
Length:430
Mass (Da):44,774
Last modified:February 1, 1997 - v1
Checksum:iE3C7DD554983FF44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17496.1.
PIRiS77393.

Genome annotation databases

EnsemblBacteriaiBAA17496; BAA17496; BAA17496.
KEGGisyn:sll1633.
PATRICi23838870. VBISynSp132158_1000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17496.1.
PIRiS77393.

3D structure databases

ProteinModelPortaliP73456.
SMRiP73456. Positions 84-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP73456. 4 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17496; BAA17496; BAA17496.
KEGGisyn:sll1633.
PATRICi23838870. VBISynSp132158_1000.

Phylogenomic databases

HOGENOMiHOG000049094.
InParanoidiP73456.
KOiK03531.
OMAiAQVIWGI.
OrthoDBiEOG6S7XZG.
PhylomeDBiP73456.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiFTSZ_SYNY3
AccessioniPrimary (citable) accession number: P73456
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 16, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.