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P73448

- NARB_SYNY3

UniProt

P73448 - NARB_SYNY3

Protein

Nitrate reductase

Gene

narB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.

    Catalytic activityi

    Nitrite + acceptor = nitrate + reduced acceptor.

    Cofactori

    Binds 1 4Fe-4S cluster.Curated
    Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi14 – 141Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
    Metal bindingi17 – 171Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
    Metal bindingi21 – 211Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
    Metal bindingi56 – 561Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. molybdenum ion binding Source: InterPro
    3. nitrate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. denitrification pathway Source: UniProtKB-UniPathway
    2. nitrate assimilation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Nitrate assimilation

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

    Enzyme and pathway databases

    UniPathwayiUPA00652; UER00706.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nitrate reductase (EC:1.7.99.4)
    Gene namesi
    Name:narB
    Ordered Locus Names:sll1454
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 714714Nitrate reductasePRO_0000063238Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiP73448. 7 interactions.
    STRINGi1148.sll1454.

    Structurei

    3D structure databases

    ProteinModelPortaliP73448.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 70644Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0243.
    HOGENOMiHOG000031440.
    KOiK00367.
    OMAiAGKMHDS.
    OrthoDBiEOG6CVV7G.
    PhylomeDBiP73448.

    Family and domain databases

    InterProiIPR009010. Asp_de-COase-like_dom.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    [Graphical view]
    PfamiPF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    [Graphical view]
    SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73448-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSPAILPTT RTLCPYCGVG CGLEAVASPQ KSVVDAGHAH KIRGDRQHPS    50
    SQGMVCVKGA TVMESMDKQR LLYPMFRSSL DQPWQQISWE AALEIVVDKI 100
    QQVKQTLGVS GLCMYASGQM QTEDYYVAQK LFKGCLGTNN FDTNSRLCMS 150
    SAVSAYSLSF GSDGPPCCYE DLEITDCAFL IGTNTADCHP IIFNRLRKHH 200
    KQNPHVKLIV VDPRCTATAE VADLHLAINP GSDITLLHGI AYLLKKWNLI 250
    DQKFIDNHTQ DFEQYCQVID HYPPEKVTQI CGISLEQLET AAHYWGNAKT 300
    VLSLWSMGMN QSFQGTAKGR CLINLHLLTG QIGKPGSGPF SLTGQPNAMG 350
    GREAGGLSHL LPGYRSIKNP QHRQEVEQLW QISPGRINPE PGLSAWEMFM 400
    GLENQQVGFL WIVATNPVVS MPDLERVKKA LQQSTFTIHQ DAYSPTETAE 450
    YAHLLLPAAQ WSEKTGTMTN SERRVTLSPA FRSPPGEARP DWEIFAEVGR 500
    RLGFENQFNF VDSAAVHREY VQLTAERLCD QSGVSYEKLQ KLGPLQWPCR 550
    QSDQESQLLS TKRLYTDYKF CTENGRANFC LDHSRGLAEP VDPNYPFVLT 600
    NGRLYGHWHT QTRTGHIEKI KKMHPKPILE MHPKDAEKLG IKSQDLVAIK 650
    SRRGSAQLEV LVTRAIAPGT VFMPMHWGFL WDDNAEVNSL THATACPISK 700
    QPELKACAVN ITPV 714
    Length:714
    Mass (Da):79,632
    Last modified:February 1, 1997 - v1
    Checksum:i702AA57ED9E605AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17488.1.
    PIRiS77385.
    RefSeqiNP_440808.1. NC_000911.1.
    YP_005650867.1. NC_017277.1.
    YP_007450691.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17488; BAA17488; BAA17488.
    GeneIDi954111.
    KEGGisyn:sll1454.
    syy:SYNGTS_0914.
    syz:MYO_19210.
    PATRICi23838852. VBISynSp132158_0991.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17488.1 .
    PIRi S77385.
    RefSeqi NP_440808.1. NC_000911.1.
    YP_005650867.1. NC_017277.1.
    YP_007450691.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P73448. 7 interactions.
    STRINGi 1148.sll1454.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17488 ; BAA17488 ; BAA17488 .
    GeneIDi 954111.
    KEGGi syn:sll1454.
    syy:SYNGTS_0914.
    syz:MYO_19210.
    PATRICi 23838852. VBISynSp132158_0991.

    Phylogenomic databases

    eggNOGi COG0243.
    HOGENOMi HOG000031440.
    KOi K00367.
    OMAi AGKMHDS.
    OrthoDBi EOG6CVV7G.
    PhylomeDBi P73448.

    Enzyme and pathway databases

    UniPathwayi UPA00652 ; UER00706 .

    Family and domain databases

    InterProi IPR009010. Asp_de-COase-like_dom.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    [Graphical view ]
    Pfami PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    [Graphical view ]
    SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    PROSITEi PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiNARB_SYNY3
    AccessioniPrimary (citable) accession number: P73448
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3