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P73448

- NARB_SYNY3

UniProt

P73448 - NARB_SYNY3

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Protein

Nitrate reductase

Gene

narB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.

Catalytic activityi

Nitrite + acceptor = nitrate + reduced acceptor.

Cofactori

Protein has several cofactor binding sites:

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
Metal bindingi17 – 171Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
Metal bindingi21 – 211Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
Metal bindingi56 – 561Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. molybdenum ion binding Source: InterPro
  3. nitrate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. denitrification pathway Source: UniProtKB-UniPathway
  2. nitrate assimilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Nitrate assimilation

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

Enzyme and pathway databases

UniPathwayiUPA00652; UER00706.

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrate reductase (EC:1.7.99.4)
Gene namesi
Name:narB
Ordered Locus Names:sll1454
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Nitrate reductasePRO_0000063238Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP73448. 7 interactions.
STRINGi1148.sll1454.

Structurei

3D structure databases

ProteinModelPortaliP73448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 70644Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0243.
HOGENOMiHOG000031440.
InParanoidiP73448.
KOiK00367.
OMAiAGKMHDS.
OrthoDBiEOG6CVV7G.
PhylomeDBiP73448.

Family and domain databases

InterProiIPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR027467. MopterinOxRdtase_cofactor_BS.
[Graphical view]
PfamiPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73448-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSPAILPTT RTLCPYCGVG CGLEAVASPQ KSVVDAGHAH KIRGDRQHPS
60 70 80 90 100
SQGMVCVKGA TVMESMDKQR LLYPMFRSSL DQPWQQISWE AALEIVVDKI
110 120 130 140 150
QQVKQTLGVS GLCMYASGQM QTEDYYVAQK LFKGCLGTNN FDTNSRLCMS
160 170 180 190 200
SAVSAYSLSF GSDGPPCCYE DLEITDCAFL IGTNTADCHP IIFNRLRKHH
210 220 230 240 250
KQNPHVKLIV VDPRCTATAE VADLHLAINP GSDITLLHGI AYLLKKWNLI
260 270 280 290 300
DQKFIDNHTQ DFEQYCQVID HYPPEKVTQI CGISLEQLET AAHYWGNAKT
310 320 330 340 350
VLSLWSMGMN QSFQGTAKGR CLINLHLLTG QIGKPGSGPF SLTGQPNAMG
360 370 380 390 400
GREAGGLSHL LPGYRSIKNP QHRQEVEQLW QISPGRINPE PGLSAWEMFM
410 420 430 440 450
GLENQQVGFL WIVATNPVVS MPDLERVKKA LQQSTFTIHQ DAYSPTETAE
460 470 480 490 500
YAHLLLPAAQ WSEKTGTMTN SERRVTLSPA FRSPPGEARP DWEIFAEVGR
510 520 530 540 550
RLGFENQFNF VDSAAVHREY VQLTAERLCD QSGVSYEKLQ KLGPLQWPCR
560 570 580 590 600
QSDQESQLLS TKRLYTDYKF CTENGRANFC LDHSRGLAEP VDPNYPFVLT
610 620 630 640 650
NGRLYGHWHT QTRTGHIEKI KKMHPKPILE MHPKDAEKLG IKSQDLVAIK
660 670 680 690 700
SRRGSAQLEV LVTRAIAPGT VFMPMHWGFL WDDNAEVNSL THATACPISK
710
QPELKACAVN ITPV
Length:714
Mass (Da):79,632
Last modified:February 1, 1997 - v1
Checksum:i702AA57ED9E605AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17488.1.
PIRiS77385.
RefSeqiNP_440808.1. NC_000911.1.
YP_005650867.1. NC_017277.1.
YP_007450691.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17488; BAA17488; BAA17488.
GeneIDi954111.
KEGGisyn:sll1454.
PATRICi23838852. VBISynSp132158_0991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17488.1 .
PIRi S77385.
RefSeqi NP_440808.1. NC_000911.1.
YP_005650867.1. NC_017277.1.
YP_007450691.1. NC_020286.1.

3D structure databases

ProteinModelPortali P73448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P73448. 7 interactions.
STRINGi 1148.sll1454.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17488 ; BAA17488 ; BAA17488 .
GeneIDi 954111.
KEGGi syn:sll1454.
PATRICi 23838852. VBISynSp132158_0991.

Phylogenomic databases

eggNOGi COG0243.
HOGENOMi HOG000031440.
InParanoidi P73448.
KOi K00367.
OMAi AGKMHDS.
OrthoDBi EOG6CVV7G.
PhylomeDBi P73448.

Enzyme and pathway databases

UniPathwayi UPA00652 ; UER00706 .

Family and domain databases

InterProi IPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR027467. MopterinOxRdtase_cofactor_BS.
[Graphical view ]
Pfami PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view ]
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
PROSITEi PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiNARB_SYNY3
AccessioniPrimary (citable) accession number: P73448
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3