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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi415Magnesium 1By similarity1
Metal bindingi422Magnesium 1By similarity1
Metal bindingi422Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:slr1550
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001526951 – 510Lysine--tRNA ligaseAdd BLAST510

Proteomic databases

PaxDbiP73443
PRIDEiP73443

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP73443, 5 interactors
STRINGi1148.SYNGTS_0909

Structurei

3D structure databases

ProteinModelPortaliP73443
SMRiP73443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000236578
InParanoidiP73443
KOiK04567
OMAiMMNIIPG
PhylomeDBiP73443

Family and domain databases

CDDicd00775 LysRS_core, 1 hit
HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR034762 Lys-tRNA-ligase_II_bac/euk
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PIRSFiPIRSF039101 LysRS2, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

P73443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSHSHSSL EEIRATRLEK AEQLRQLGLN PYAYTWEITH QAQDLQETYR
60 70 80 90 100
DLSNGEEVDL KVAIAGRILA RRVMGKLAFF TLQDESGTIQ LYLEKQRLTE
110 120 130 140 150
HMPELENAFN LLKKITDVGD ILGVTGTLKR TEKGELSVYV QTYAVLTKSL
160 170 180 190 200
LPLPDKWHGL TDTEKRYRQR YVDLIVNPTV RQTFRRRAQI TAAIRRYLDK
210 220 230 240 250
QGFIEIETPV LQGESGGAEA RPFITHHNTL GMPLYLRIAT ELHLKRLVVG
260 270 280 290 300
GFEKVFELGR IFRNEGVSTR HNPEFTSIEV YQAYVDYNEM MALTEALVTT
310 320 330 340 350
AAQAVLGTLK ITYQGEEIDL TPPWKRITMH EAVQLETGID FSQFTDLETA
360 370 380 390 400
KQAATKAGIG VPEDCPSLGH LLNHAFEQKV EGTLMQPTFI IDFPVEISPL
410 420 430 440 450
AKPHRSKPGL VERFELFVYG RELANSFSEL TDPIDQRSRL EAQAAKKAAG
460 470 480 490 500
DLEAHSVDED FLTALEYGMP PTGGLGIGID RLVMLLTDSP SIRDVIAFPL
510
LKNQEAGSDG
Length:510
Mass (Da):57,295
Last modified:February 1, 1997 - v1
Checksum:iF5897E92F0686704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA17483.1
PIRiS77380

Genome annotation databases

EnsemblBacteriaiBAA17483; BAA17483; BAA17483
KEGGisyn:slr1550

Similar proteinsi

Entry informationi

Entry nameiSYK_SYNY3
AccessioniPrimary (citable) accession number: P73443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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