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Protein

Peptide deformylase

Gene

def

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).By similarity

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi107IronBy similarity1
Metal bindingi149IronBy similarity1
Active sitei150By similarity1
Metal bindingi153IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:slr1549
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000828651 – 187Peptide deformylaseAdd BLAST187

Proteomic databases

PaxDbiP73441
PRIDEiP73441

Interactioni

Protein-protein interaction databases

IntActiP73441, 2 interactors
STRINGi1148.SYNGTS_0907

Structurei

3D structure databases

ProteinModelPortaliP73441
SMRiP73441
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.Curated

Phylogenomic databases

HOGENOMiHOG000243509
InParanoidiP73441
KOiK01462
OMAiVCIQHEI
PhylomeDBiP73441

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

P73441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATILVEKQ KVDRPPLELH YLGDKVLRQP AKRIAKVDDS IRKLAKEMLQ
60 70 80 90 100
TMYSANGIGL AAPQVGINKQ LLVVDCEQDK PDEPPLIMIN PQITRTSEEL
110 120 130 140 150
CVVEEGCLSV PNVYMDVTRP RAIEVTYKDE HGRPQKRLFA ELTARVIQHE
160 170 180
MDHLNGVMFV DRVDNPLALA ESLKKEGFSM QAVKPVA
Length:187
Mass (Da):21,026
Last modified:February 1, 1997 - v1
Checksum:i0426D753D31C9891
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA17481.1
PIRiS77378

Genome annotation databases

EnsemblBacteriaiBAA17481; BAA17481; BAA17481
KEGGisyn:slr1549

Similar proteinsi

Entry informationi

Entry nameiDEF_SYNY3
AccessioniPrimary (citable) accession number: P73441
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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