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P73441

- DEF_SYNY3

UniProt

P73441 - DEF_SYNY3

Protein

Peptide deformylase

Gene

def

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.By similarity

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

    Cofactori

    Binds 1 Fe2+ ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi107 – 1071IronBy similarity
    Metal bindingi149 – 1491IronBy similarity
    Active sitei150 – 1501By similarity
    Metal bindingi153 – 1531IronBy similarity

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylase (EC:3.5.1.88)
    Short name:
    PDF
    Alternative name(s):
    Polypeptide deformylase
    Gene namesi
    Name:def
    Ordered Locus Names:slr1549
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 187187Peptide deformylasePRO_0000082865Add
    BLAST

    Proteomic databases

    PaxDbiP73441.

    Interactioni

    Protein-protein interaction databases

    IntActiP73441. 2 interactions.
    STRINGi1148.slr1549.

    Structurei

    3D structure databases

    ProteinModelPortaliP73441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243509.
    KOiK01462.
    OMAiEETGEEW.
    OrthoDBiEOG664CMF.
    PhylomeDBiP73441.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P73441-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTATILVEKQ KVDRPPLELH YLGDKVLRQP AKRIAKVDDS IRKLAKEMLQ    50
    TMYSANGIGL AAPQVGINKQ LLVVDCEQDK PDEPPLIMIN PQITRTSEEL 100
    CVVEEGCLSV PNVYMDVTRP RAIEVTYKDE HGRPQKRLFA ELTARVIQHE 150
    MDHLNGVMFV DRVDNPLALA ESLKKEGFSM QAVKPVA 187
    Length:187
    Mass (Da):21,026
    Last modified:February 1, 1997 - v1
    Checksum:i0426D753D31C9891
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17481.1.
    PIRiS77378.
    RefSeqiNP_440801.1. NC_000911.1.
    YP_005650860.1. NC_017277.1.
    YP_007450684.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17481; BAA17481; BAA17481.
    GeneIDi954104.
    KEGGisyn:slr1549.
    syy:SYNGTS_0907.
    syz:MYO_19140.
    PATRICi23838834. VBISynSp132158_0982.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17481.1 .
    PIRi S77378.
    RefSeqi NP_440801.1. NC_000911.1.
    YP_005650860.1. NC_017277.1.
    YP_007450684.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P73441. 2 interactions.
    STRINGi 1148.slr1549.

    Proteomic databases

    PaxDbi P73441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17481 ; BAA17481 ; BAA17481 .
    GeneIDi 954104.
    KEGGi syn:slr1549.
    syy:SYNGTS_0907.
    syz:MYO_19140.
    PATRICi 23838834. VBISynSp132158_0982.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243509.
    KOi K01462.
    OMAi EETGEEW.
    OrthoDBi EOG664CMF.
    PhylomeDBi P73441.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiDEF_SYNY3
    AccessioniPrimary (citable) accession number: P73441
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3