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P73411 (G6PD_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf
Ordered Locus Names:slr1843
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000068135

Sites

Active site2591Proton acceptor By similarity
Binding site621NADP By similarity
Binding site1671NADP By similarity
Binding site1971Substrate By similarity
Binding site2011Substrate By similarity
Binding site2351Substrate By similarity
Binding site2541Substrate By similarity
Binding site3591Substrate By similarity
Binding site3641Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P73411 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: EC24FE8D1AFFC238

FASTA50957,886
        10         20         30         40         50         60 
MVTLLENPFR TGLRQERTPE PLILTIFGAS GDLTQRKLVP AIYQMKRERR LPPELTVVGF 

        70         80         90        100        110        120 
ARRDWSHDHF REQMRKGIEE FSTGIGSEDL WNEFAQGLFY CSGNMDDPES YLKLKNFLGE 

       130        140        150        160        170        180 
LDEKRNTRGN RVFYLAVSPN FFPPGIKQLG AAGMLSDPVK SRIVIEKPFG RDLSSAQSLN 

       190        200        210        220        230        240 
RVVQSVCKEN QVYRIDHYLG KETVQNLMVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE 

       250        260        270        280        290        300 
ERAGYYESAG ALRDMVQNHL MQLFCLTAMD PPNAIDADSI RNEKVKVLQA TRLADINNLE 

       310        320        330        340        350        360 
NAGIRGQYKA GWMGGKPVPG YREEPGVDPS STTPTFAALK LMVDNWRWQG VPFYLRTGKR 

       370        380        390        400        410        420 
MPKKVSEIAI QFRQVPLLIF QSVAHQANPN VLSLRIQPNE GISLRFEAKM PGSELRTRTV 

       430        440        450        460        470        480 
DMDFSYGSSF GVAAADAYHR LLLDCMLGDQ TLFTRADEVE EAWRVVTPVL SAWDAPSDPL 

       490        500 
SMPLYEAGTW EPAEAEWLIN KDGRRWRRL 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA17451.1.
PIRS77348.
RefSeqNP_440771.1. NC_000911.1.
YP_005650830.1. NC_017277.1.
YP_007450654.1. NC_020286.1.

3D structure databases

ProteinModelPortalP73411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP73411. 1 interaction.
STRING1148.slr1843.

Proteomic databases

PaxDbP73411.
PRIDEP73411.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17451; BAA17451; BAA17451.
GeneID954074.
KEGGsyn:slr1843.
syy:SYNGTS_0877.
syz:MYO_18830.
PATRIC23838768. VBISynSp132158_0950.

Phylogenomic databases

eggNOGCOG0364.
HOGENOMHOG000046191.
KOK00036.
OMAWRWVEPL.
OrthoDBEOG61308Z.
PhylomeDBP73411.

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_SYNY3
AccessionPrimary (citable) accession number: P73411
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways