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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621NADPUniRule annotation
Binding sitei167 – 1671NADPUniRule annotation
Binding sitei197 – 1971SubstrateUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Binding sitei235 – 2351SubstrateUniRule annotation
Binding sitei254 – 2541SubstrateUniRule annotation
Active sitei259 – 2591Proton acceptorUniRule annotation
Binding sitei359 – 3591SubstrateUniRule annotation
Binding sitei364 – 3641SubstrateUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:slr1843
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Glucose-6-phosphate 1-dehydrogenasePRO_0000068135Add
BLAST

Proteomic databases

PaxDbiP73411.
PRIDEiP73411.

Interactioni

Protein-protein interaction databases

IntActiP73411. 1 interaction.
STRINGi1148.slr1843.

Structurei

3D structure databases

ProteinModelPortaliP73411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
InParanoidiP73411.
KOiK00036.
OMAiTIFEPIW.
OrthoDBiEOG61308Z.
PhylomeDBiP73411.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTLLENPFR TGLRQERTPE PLILTIFGAS GDLTQRKLVP AIYQMKRERR
60 70 80 90 100
LPPELTVVGF ARRDWSHDHF REQMRKGIEE FSTGIGSEDL WNEFAQGLFY
110 120 130 140 150
CSGNMDDPES YLKLKNFLGE LDEKRNTRGN RVFYLAVSPN FFPPGIKQLG
160 170 180 190 200
AAGMLSDPVK SRIVIEKPFG RDLSSAQSLN RVVQSVCKEN QVYRIDHYLG
210 220 230 240 250
KETVQNLMVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE ERAGYYESAG
260 270 280 290 300
ALRDMVQNHL MQLFCLTAMD PPNAIDADSI RNEKVKVLQA TRLADINNLE
310 320 330 340 350
NAGIRGQYKA GWMGGKPVPG YREEPGVDPS STTPTFAALK LMVDNWRWQG
360 370 380 390 400
VPFYLRTGKR MPKKVSEIAI QFRQVPLLIF QSVAHQANPN VLSLRIQPNE
410 420 430 440 450
GISLRFEAKM PGSELRTRTV DMDFSYGSSF GVAAADAYHR LLLDCMLGDQ
460 470 480 490 500
TLFTRADEVE EAWRVVTPVL SAWDAPSDPL SMPLYEAGTW EPAEAEWLIN

KDGRRWRRL
Length:509
Mass (Da):57,886
Last modified:February 1, 1997 - v1
Checksum:iEC24FE8D1AFFC238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17451.1.
PIRiS77348.
RefSeqiNP_440771.1. NC_000911.1.
YP_005650830.1. NC_017277.1.
YP_007450654.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17451; BAA17451; BAA17451.
GeneIDi954074.
KEGGisyn:slr1843.
PATRICi23838768. VBISynSp132158_0950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17451.1.
PIRiS77348.
RefSeqiNP_440771.1. NC_000911.1.
YP_005650830.1. NC_017277.1.
YP_007450654.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP73411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP73411. 1 interaction.
STRINGi1148.slr1843.

Proteomic databases

PaxDbiP73411.
PRIDEiP73411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17451; BAA17451; BAA17451.
GeneIDi954074.
KEGGisyn:slr1843.
PATRICi23838768. VBISynSp132158_0950.

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
InParanoidiP73411.
KOiK00036.
OMAiTIFEPIW.
OrthoDBiEOG61308Z.
PhylomeDBiP73411.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiG6PD_SYNY3
AccessioniPrimary (citable) accession number: P73411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 4, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.