P73411 (G6PD_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate 1-dehydrogenase
Short name=G6PD
EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	slr1843

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068135
Sites
	Active site	259	1	Proton acceptor By similarity
	Binding site	30	1	NADP By similarity
	Binding site	62	1	NADP By similarity
	Binding site	197	1	Substrate By similarity
	Binding site	201	1	Substrate By similarity
	Binding site	364	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P73411 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: EC24FE8D1AFFC238	FASTA	509	57,886
	10 20 30 40 50 60 MVTLLENPFR TGLRQERTPE PLILTIFGAS GDLTQRKLVP AIYQMKRERR LPPELTVVGF 70 80 90 100 110 120 ARRDWSHDHF REQMRKGIEE FSTGIGSEDL WNEFAQGLFY CSGNMDDPES YLKLKNFLGE 130 140 150 160 170 180 LDEKRNTRGN RVFYLAVSPN FFPPGIKQLG AAGMLSDPVK SRIVIEKPFG RDLSSAQSLN 190 200 210 220 230 240 RVVQSVCKEN QVYRIDHYLG KETVQNLMVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE 250 260 270 280 290 300 ERAGYYESAG ALRDMVQNHL MQLFCLTAMD PPNAIDADSI RNEKVKVLQA TRLADINNLE 310 320 330 340 350 360 NAGIRGQYKA GWMGGKPVPG YREEPGVDPS STTPTFAALK LMVDNWRWQG VPFYLRTGKR 370 380 390 400 410 420 MPKKVSEIAI QFRQVPLLIF QSVAHQANPN VLSLRIQPNE GISLRFEAKM PGSELRTRTV 430 440 450 460 470 480 DMDFSYGSSF GVAAADAYHR LLLDCMLGDQ TLFTRADEVE EAWRVVTPVL SAWDAPSDPL 490 500 SMPLYEAGTW EPAEAEWLIN KDGRRWRRL

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA17451.1.
PIR	S77348.
RefSeq	NP_440771.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P73411.
ModBase	Search...
Protein-protein interaction databases
IntAct	P73411. 1 interaction.
STRING	P73411.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	954074.
GenomeReviews	Gene locus slr1843 in contig BA000022_GR.
KEGG	syn:slr1843.
NMPDR	fig|1148.1.peg.872.
PATRIC	23838768. VBISynSp132158_0950.
Phylogenomic databases
eggNOG	COG0364.
HOGENOM	HBG322449.
OMA	FANQMFE.
PhylomeDB	P73411.
ProtClustDB	PRK05722.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1843-MONOMER.
Family and domain databases
InterPro	IPR001282. G6P_DH. IPR019796. G6P_DH_AS. IPR022675. G6P_DH_C. IPR022674. G6P_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00036.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
TIGRFAMs	TIGR00871. Zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_SYNY3

Accession

Primary (citable) accession number: P73411

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program