Reviewed, UniProtKB/Swiss-Prot P73374 (Y1967_SYNY3)

Names and origin

Protein names

Recommended name:
    Uncharacterized RNA methyltransferase sll1967
    EC=2.1.1.-

Gene names

Ordered Locus Names:

sll1967

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Sequence similarities

Belongs to the methyltransferase superfamily. RNA M5U methyltransferase family. Contains 1 TRAM domain.

Ontologies

Keywords
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: InterPro RNA methyltransferase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Uncharacterized RNA methyltransferase sll1967		PRO_0000162045
Regions
	Domain	12 – 70	59	TRAM
Sites
	Active site	417	1	Nucleophile By similarity
	Metal binding	83	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	89	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	92	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	171	1	Iron-sulfur (4Fe-4S) By similarity
	Binding site	295	1	S-adenosyl-L-methionine By similarity
	Binding site	324	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	345	1	S-adenosyl-L-methionine By similarity
	Binding site	390	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P73374-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: E62A75121A84883C	FASTA	463	51,523
	10 20 30 40 50 60 MTQSNNFATS PLWQQGSVVE LTITGLNHQG EGIGRFNERV VFVPDTAPGD RLEVRLVKVK 70 80 90 100 110 120 RNYALAQLLK ILEPSVQRTR PSCIVADKCG GCQWQHLDYQ FQVESKQQQI IDALERIGGF 130 140 150 160 170 180 TTLPLEPLLQ SPASLGYRNK ATYPLSRSKT GQVQAGYYRK GSHRLVNINQ CPVQDDRLNL 190 200 210 220 230 240 LLTEVKKDIE NRGWSIYDEE KKQGKLRHLS LRIGQRTGEM LLTLISAHKG LPDLEEQAGE 250 260 270 280 290 300 WLERYPDLGG ICLNIQPEPN NRIFGDETVV IAGRGICREK FADLSFSLGA NTFFQVNSGA 310 320 330 340 350 360 AELLLTRLQQ ALNLQGAELL VDAYAGVGTF TLPLARQVRQ AIAIEVNQDS VHQGQRNAEI 370 380 390 400 410 420 NQIANVDFLA GTVETVLPTL SEIPDVLLLD PPRKGCAPEV LREIIRQRPE KIAYISCQPP 430 440 450 460 TLARDLKFLC AEGFYGITWV QGCDFFPQTA HVECAVILKA VNG

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA17405.1.
PIR	S77558.
RefSeq	NP_440725.1.
3D structure databases
SMR	P73374. Positions 19-458.
ModBase	Search...
Protein-protein interaction databases
IntAct	P73374. 10 interactions.
STRING	P73374.
Genome annotation databases
GeneID	954028.
GenomeReviews	Gene locus sll1967 in contig BA000022_GR.
KEGG	syn:sll1967.
NMPDR	fig|1148.1.peg.826.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2265.
HOGENOM	HBG690163.
OMA	GAGCCDF.
PhylomeDB	P73374.
Enzyme and pathway databases
BioCyc	SSP1148:SLL1967-MONOMER.
Family and domain databases
InterPro	IPR016027. NA-bd_OB-fold-like. IPR001566. RumA_MeTrfase. IPR002792. TRAM. IPR010280. U5_MeTrfase. [Graphical view]
Pfam	PF01938. TRAM. 1 hit. PF05958. tRNA_U5-meth_tr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00479. rumA. 1 hit.
PROSITE	PS50926. TRAM. 1 hit. PS01230. TRMA_1. 1 hit. PS01231. TRMA_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y1967_SYNY3

Accession

Primary (citable) accession number: P73374

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	February 1, 1997
Last modified:	February 9, 2010
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)