P73367 (AROQ_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type II DHQase

Gene names

Name:	aroQ
Ordered Locus Names:	sll1112

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a trans-dehydration via an enolate intermediate By similarity. HAMAP-Rule MF_00169
Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP-Rule MF_00169
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP-Rule MF_00169
Subunit structure	Homododecamer By similarity. HAMAP-Rule MF_00169
Sequence similarities	Belongs to the type-II 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 152	152	3-dehydroquinate dehydratase HAMAP-Rule MF_00169		PRO_0000159933
Regions
	Region	104 – 105	2	Substrate binding By similarity
Sites
	Active site	26	1	Proton acceptor By similarity
	Active site	103	1	Proton donor By similarity
	Binding site	77	1	Substrate By similarity
	Binding site	83	1	Substrate By similarity
	Binding site	90	1	Substrate By similarity
	Binding site	114	1	Substrate By similarity
	Site	21	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	P73367 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 360092AEF938A2C6	FASTA	152	16,375
	10 20 30 40 50 60 MTTVWKVLVL HGPNLNLLGQ REPGIYGSLT LGEIDACLRE DGVDLEAEVS TFQSNSEGQL 70 80 90 100 110 120 VTAIHGALGN YHGIVFNAAA YTHTSIALRD ALAAVQLPCV EVHLSNIHKR ESFRHISHIA 130 140 150 PVAIGQICGF GLNSYRLGLR ALVDYLNGQA DS

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA17398.1.
PIR	S77551.
RefSeq	NP_440718.1. NC_000911.1. YP_005650777.1. NC_017277.1. YP_007450601.1. NC_020286.1.
3D structure databases
ProteinModelPortal	P73367.
ModBase	Search...
Protein-protein interaction databases
IntAct	P73367. 1 interaction.
STRING	1148.sll1112.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA17398; BAA17398; BAA17398.
GeneID	12254699. 14616251. 954021.
KEGG	syn:sll1112. syy:SYNGTS_0824.
PATRIC	23838646. VBISynSp132158_0890.
Phylogenomic databases
eggNOG	COG0757.
HOGENOM	HOG000217278.
KO	K03786.
OMA	THYGLAL.
ProtClustDB	PRK05395.
Enzyme and pathway databases
UniPathway	UPA00053; UER00086.
Family and domain databases
Gene3D	3.40.50.9100. 1 hit.
HAMAP	MF_00169. AroQ.
InterPro	IPR001874. DHquinase_II. IPR018509. DHquinase_II_CS. [Graphical view]
PANTHER	PTHR21272. PTHR21272. 1 hit.
Pfam	PF01220. DHquinase_II. 1 hit. [Graphical view]
PIRSF	PIRSF001399. DHquinase_II. 1 hit.
ProDom	PD004527. DHquinase_II. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF52304. DHquinase_II. 1 hit.
TIGRFAMs	TIGR01088. aroQ. 1 hit.
PROSITE	PS01029. DEHYDROQUINASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROQ_SYNY3

Accession

Primary (citable) accession number: P73367

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program