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P73367

- AROQ_SYNY3

UniProt

P73367 - AROQ_SYNY3

Protein

3-dehydroquinate dehydratase

Gene

aroQ

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes a trans-dehydration via an enolate intermediate.By similarity

    Catalytic activityi

    3-dehydroquinate = 3-dehydroshikimate + H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei21 – 211Transition state stabilizerBy similarity
    Active sitei26 – 261Proton acceptorBy similarity
    Binding sitei77 – 771SubstrateBy similarity
    Binding sitei83 – 831SubstrateBy similarity
    Binding sitei90 – 901SubstrateBy similarity
    Active sitei103 – 1031Proton donorBy similarity
    Binding sitei114 – 1141SubstrateBy similarity

    GO - Molecular functioni

    1. 3-dehydroquinate dehydratase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00053; UER00086.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-dehydroquinate dehydratase (EC:4.2.1.10)
    Short name:
    3-dehydroquinase
    Alternative name(s):
    Type II DHQase
    Gene namesi
    Name:aroQ
    Ordered Locus Names:sll1112
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1521523-dehydroquinate dehydratasePRO_0000159933Add
    BLAST

    Interactioni

    Subunit structurei

    Homododecamer.By similarity

    Protein-protein interaction databases

    IntActiP73367. 1 interaction.
    STRINGi1148.sll1112.

    Structurei

    3D structure databases

    ProteinModelPortaliP73367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni104 – 1052Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the type-II 3-dehydroquinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0757.
    HOGENOMiHOG000217278.
    KOiK03786.
    OMAiDFRHHSF.
    OrthoDBiEOG66MQVT.
    PhylomeDBiP73367.

    Family and domain databases

    Gene3Di3.40.50.9100. 1 hit.
    HAMAPiMF_00169. AroQ.
    InterProiIPR001874. DHquinase_II.
    IPR018509. DHquinase_II_CS.
    [Graphical view]
    PANTHERiPTHR21272. PTHR21272. 1 hit.
    PfamiPF01220. DHquinase_II. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001399. DHquinase_II. 1 hit.
    ProDomiPD004527. DHquinase_II. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF52304. SSF52304. 1 hit.
    TIGRFAMsiTIGR01088. aroQ. 1 hit.
    PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73367-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTVWKVLVL HGPNLNLLGQ REPGIYGSLT LGEIDACLRE DGVDLEAEVS    50
    TFQSNSEGQL VTAIHGALGN YHGIVFNAAA YTHTSIALRD ALAAVQLPCV 100
    EVHLSNIHKR ESFRHISHIA PVAIGQICGF GLNSYRLGLR ALVDYLNGQA 150
    DS 152
    Length:152
    Mass (Da):16,375
    Last modified:February 1, 1997 - v1
    Checksum:i360092AEF938A2C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17398.1.
    PIRiS77551.
    RefSeqiNP_440718.1. NC_000911.1.
    YP_005650777.1. NC_017277.1.
    YP_007450601.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17398; BAA17398; BAA17398.
    GeneIDi954021.
    KEGGisyn:sll1112.
    syy:SYNGTS_0824.
    syz:MYO_18290.
    PATRICi23838646. VBISynSp132158_0890.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17398.1 .
    PIRi S77551.
    RefSeqi NP_440718.1. NC_000911.1.
    YP_005650777.1. NC_017277.1.
    YP_007450601.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P73367. 1 interaction.
    STRINGi 1148.sll1112.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17398 ; BAA17398 ; BAA17398 .
    GeneIDi 954021.
    KEGGi syn:sll1112.
    syy:SYNGTS_0824.
    syz:MYO_18290.
    PATRICi 23838646. VBISynSp132158_0890.

    Phylogenomic databases

    eggNOGi COG0757.
    HOGENOMi HOG000217278.
    KOi K03786.
    OMAi DFRHHSF.
    OrthoDBi EOG66MQVT.
    PhylomeDBi P73367.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00086 .

    Family and domain databases

    Gene3Di 3.40.50.9100. 1 hit.
    HAMAPi MF_00169. AroQ.
    InterProi IPR001874. DHquinase_II.
    IPR018509. DHquinase_II_CS.
    [Graphical view ]
    PANTHERi PTHR21272. PTHR21272. 1 hit.
    Pfami PF01220. DHquinase_II. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001399. DHquinase_II. 1 hit.
    ProDomi PD004527. DHquinase_II. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF52304. SSF52304. 1 hit.
    TIGRFAMsi TIGR01088. aroQ. 1 hit.
    PROSITEi PS01029. DEHYDROQUINASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiAROQ_SYNY3
    AccessioniPrimary (citable) accession number: P73367
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3