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Protein

3-dehydroquinate dehydratase

Gene

aroQ

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a trans-dehydration via an enolate intermediate.By similarity

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.

Pathwayi: chorismate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei21Transition state stabilizerBy similarity1
Active sitei26Proton acceptorBy similarity1
Binding sitei77SubstrateBy similarity1
Binding sitei83SubstrateBy similarity1
Binding sitei90SubstrateBy similarity1
Active sitei103Proton donorBy similarity1
Binding sitei114SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydratase (EC:4.2.1.10)
Short name:
3-dehydroquinase
Alternative name(s):
Type II DHQase
Gene namesi
Name:aroQ
Ordered Locus Names:sll1112
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001599331 – 1523-dehydroquinate dehydrataseAdd BLAST152

Interactioni

Subunit structurei

Homododecamer.By similarity

Protein-protein interaction databases

IntActiP73367. 1 interactor.
STRINGi1148.SYNGTS_0824.

Structurei

3D structure databases

ProteinModelPortaliP73367.
SMRiP73367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 105Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the type-II 3-dehydroquinase family.Curated

Phylogenomic databases

HOGENOMiHOG000217278.
InParanoidiP73367.
KOiK03786.
OMAiAYTHYSY.
PhylomeDBiP73367.

Family and domain databases

CDDicd00466. DHQase_II. 1 hit.
Gene3Di3.40.50.9100. 1 hit.
HAMAPiMF_00169. AroQ. 1 hit.
InterProiView protein in InterPro
IPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
PANTHERiPTHR21272. PTHR21272. 1 hit.
PfamiView protein in Pfam
PF01220. DHquinase_II. 1 hit.
PIRSFiPIRSF001399. DHquinase_II. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004527. DHquinase_II. 1 hit.
SUPFAMiSSF52304. SSF52304. 1 hit.
TIGRFAMsiTIGR01088. aroQ. 1 hit.
PROSITEiView protein in PROSITE
PS01029. DEHYDROQUINASE_II. 1 hit.

Sequencei

Sequence statusi: Complete.

P73367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTVWKVLVL HGPNLNLLGQ REPGIYGSLT LGEIDACLRE DGVDLEAEVS
60 70 80 90 100
TFQSNSEGQL VTAIHGALGN YHGIVFNAAA YTHTSIALRD ALAAVQLPCV
110 120 130 140 150
EVHLSNIHKR ESFRHISHIA PVAIGQICGF GLNSYRLGLR ALVDYLNGQA

DS
Length:152
Mass (Da):16,375
Last modified:February 1, 1997 - v1
Checksum:i360092AEF938A2C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17398.1.
PIRiS77551.

Genome annotation databases

EnsemblBacteriaiBAA17398; BAA17398; BAA17398.
KEGGisyn:sll1112.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAROQ_SYNY3
AccessioniPrimary (citable) accession number: P73367
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: July 5, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names