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P73367

- AROQ_SYNY3

UniProt

P73367 - AROQ_SYNY3

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Protein

3-dehydroquinate dehydratase

Gene

aroQ

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes a trans-dehydration via an enolate intermediate.By similarity

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei21 – 211Transition state stabilizerBy similarity
Active sitei26 – 261Proton acceptorBy similarity
Binding sitei77 – 771SubstrateBy similarity
Binding sitei83 – 831SubstrateBy similarity
Binding sitei90 – 901SubstrateBy similarity
Active sitei103 – 1031Proton donorBy similarity
Binding sitei114 – 1141SubstrateBy similarity

GO - Molecular functioni

  1. 3-dehydroquinate dehydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydratase (EC:4.2.1.10)
Short name:
3-dehydroquinase
Alternative name(s):
Type II DHQase
Gene namesi
Name:aroQ
Ordered Locus Names:sll1112
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1521523-dehydroquinate dehydratasePRO_0000159933Add
BLAST

Interactioni

Subunit structurei

Homododecamer.By similarity

Protein-protein interaction databases

IntActiP73367. 1 interaction.
STRINGi1148.sll1112.

Structurei

3D structure databases

ProteinModelPortaliP73367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 1052Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the type-II 3-dehydroquinase family.Curated

Phylogenomic databases

eggNOGiCOG0757.
HOGENOMiHOG000217278.
InParanoidiP73367.
KOiK03786.
OMAiDFRHHSF.
OrthoDBiEOG66MQVT.
PhylomeDBiP73367.

Family and domain databases

Gene3Di3.40.50.9100. 1 hit.
HAMAPiMF_00169. AroQ.
InterProiIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERiPTHR21272. PTHR21272. 1 hit.
PfamiPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF001399. DHquinase_II. 1 hit.
ProDomiPD004527. DHquinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52304. SSF52304. 1 hit.
TIGRFAMsiTIGR01088. aroQ. 1 hit.
PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73367-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTVWKVLVL HGPNLNLLGQ REPGIYGSLT LGEIDACLRE DGVDLEAEVS
60 70 80 90 100
TFQSNSEGQL VTAIHGALGN YHGIVFNAAA YTHTSIALRD ALAAVQLPCV
110 120 130 140 150
EVHLSNIHKR ESFRHISHIA PVAIGQICGF GLNSYRLGLR ALVDYLNGQA

DS
Length:152
Mass (Da):16,375
Last modified:February 1, 1997 - v1
Checksum:i360092AEF938A2C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17398.1.
PIRiS77551.
RefSeqiNP_440718.1. NC_000911.1.
YP_005650777.1. NC_017277.1.
YP_007450601.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17398; BAA17398; BAA17398.
GeneIDi954021.
KEGGisyn:sll1112.
PATRICi23838646. VBISynSp132158_0890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17398.1 .
PIRi S77551.
RefSeqi NP_440718.1. NC_000911.1.
YP_005650777.1. NC_017277.1.
YP_007450601.1. NC_020286.1.

3D structure databases

ProteinModelPortali P73367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P73367. 1 interaction.
STRINGi 1148.sll1112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17398 ; BAA17398 ; BAA17398 .
GeneIDi 954021.
KEGGi syn:sll1112.
PATRICi 23838646. VBISynSp132158_0890.

Phylogenomic databases

eggNOGi COG0757.
HOGENOMi HOG000217278.
InParanoidi P73367.
KOi K03786.
OMAi DFRHHSF.
OrthoDBi EOG66MQVT.
PhylomeDBi P73367.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00086 .

Family and domain databases

Gene3Di 3.40.50.9100. 1 hit.
HAMAPi MF_00169. AroQ.
InterProi IPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view ]
PANTHERi PTHR21272. PTHR21272. 1 hit.
Pfami PF01220. DHquinase_II. 1 hit.
[Graphical view ]
PIRSFi PIRSF001399. DHquinase_II. 1 hit.
ProDomi PD004527. DHquinase_II. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF52304. SSF52304. 1 hit.
TIGRFAMsi TIGR01088. aroQ. 1 hit.
PROSITEi PS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiAROQ_SYNY3
AccessioniPrimary (citable) accession number: P73367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3