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Protein

3-dehydroquinate dehydratase

Gene

aroQ

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a trans-dehydration via an enolate intermediate.By similarity

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei21 – 211Transition state stabilizerBy similarity
Active sitei26 – 261Proton acceptorBy similarity
Binding sitei77 – 771SubstrateBy similarity
Binding sitei83 – 831SubstrateBy similarity
Binding sitei90 – 901SubstrateBy similarity
Active sitei103 – 1031Proton donorBy similarity
Binding sitei114 – 1141SubstrateBy similarity

GO - Molecular functioni

  1. 3-dehydroquinate dehydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydratase (EC:4.2.1.10)
Short name:
3-dehydroquinase
Alternative name(s):
Type II DHQase
Gene namesi
Name:aroQ
Ordered Locus Names:sll1112
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1521523-dehydroquinate dehydratasePRO_0000159933Add
BLAST

Interactioni

Subunit structurei

Homododecamer.By similarity

Protein-protein interaction databases

IntActiP73367. 1 interaction.
STRINGi1148.sll1112.

Structurei

3D structure databases

ProteinModelPortaliP73367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 1052Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the type-II 3-dehydroquinase family.Curated

Phylogenomic databases

eggNOGiCOG0757.
HOGENOMiHOG000217278.
InParanoidiP73367.
KOiK03786.
OMAiHFQSNAE.
OrthoDBiEOG66MQVT.
PhylomeDBiP73367.

Family and domain databases

Gene3Di3.40.50.9100. 1 hit.
HAMAPiMF_00169. AroQ.
InterProiIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERiPTHR21272. PTHR21272. 1 hit.
PfamiPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF001399. DHquinase_II. 1 hit.
ProDomiPD004527. DHquinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52304. SSF52304. 1 hit.
TIGRFAMsiTIGR01088. aroQ. 1 hit.
PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTVWKVLVL HGPNLNLLGQ REPGIYGSLT LGEIDACLRE DGVDLEAEVS
60 70 80 90 100
TFQSNSEGQL VTAIHGALGN YHGIVFNAAA YTHTSIALRD ALAAVQLPCV
110 120 130 140 150
EVHLSNIHKR ESFRHISHIA PVAIGQICGF GLNSYRLGLR ALVDYLNGQA

DS
Length:152
Mass (Da):16,375
Last modified:February 1, 1997 - v1
Checksum:i360092AEF938A2C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17398.1.
PIRiS77551.
RefSeqiNP_440718.1. NC_000911.1.
YP_005650777.1. NC_017277.1.
YP_007450601.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17398; BAA17398; BAA17398.
KEGGisyn:sll1112.
PATRICi23838646. VBISynSp132158_0890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17398.1.
PIRiS77551.
RefSeqiNP_440718.1. NC_000911.1.
YP_005650777.1. NC_017277.1.
YP_007450601.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP73367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP73367. 1 interaction.
STRINGi1148.sll1112.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17398; BAA17398; BAA17398.
KEGGisyn:sll1112.
PATRICi23838646. VBISynSp132158_0890.

Phylogenomic databases

eggNOGiCOG0757.
HOGENOMiHOG000217278.
InParanoidiP73367.
KOiK03786.
OMAiHFQSNAE.
OrthoDBiEOG66MQVT.
PhylomeDBiP73367.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086.

Family and domain databases

Gene3Di3.40.50.9100. 1 hit.
HAMAPiMF_00169. AroQ.
InterProiIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERiPTHR21272. PTHR21272. 1 hit.
PfamiPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF001399. DHquinase_II. 1 hit.
ProDomiPD004527. DHquinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52304. SSF52304. 1 hit.
TIGRFAMsiTIGR01088. aroQ. 1 hit.
PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiAROQ_SYNY3
AccessioniPrimary (citable) accession number: P73367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: April 1, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.