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Protein

Putative serine protease HtrA

Gene

htrA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

BioCyciSSP1148:GJOT-819-MONOMER.

Protein family/group databases

MEROPSiS01.482.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine protease HtrA
Gene namesi
Name:htrA
Ordered Locus Names:slr1204
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No effect in a single knockout, but growth is inhibited at high light (120 µmol photons/m2/s) or at elevated temperature in a triple protease knockout mutant (hhoA, hhoB and htrA). Triple mutants are not phototactic. No effect on the PSII repair cycle, even in the triple protease knockout strain.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Putative serine protease HtrAPRO_0000400422Add
BLAST

Expressioni

Inductioni

No induction by UV-B light.1 Publication

Interactioni

Protein-protein interaction databases

IntActiP73354. 22 interactions.

Structurei

3D structure databases

ProteinModelPortaliP73354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini352 – 43483PDZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000223641.
InParanoidiP73354.
OMAiNQIGAPD.
OrthoDBiEOG61ZTDN.
PhylomeDBiP73354.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73354-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQAVFPIA PHRADFFPRF VLSNSSANKC HQAMKDVSLH SPKQTPSKIS
60 70 80 90 100
LAYLGLVLVG MGIGAGGTFV LTNPQWADHL TNNSVISPLV TNQSIAPANE
110 120 130 140 150
SLATNLQSRL SPREPSNFVV DVVESTGPAV VRINAQKTVK SQVPQAFNDP
160 170 180 190 200
FLQRFFGSQM PPMPNERVQR GTGSGFIVSN DGKIFTNAHV VDGADEVTVT
210 220 230 240 250
LKDGRSFPGR VMGSDPSTDV AVVKIEAGDL PTVALGDSDH LQVGEWAIAI
260 270 280 290 300
GNPLGLDNTV TTGILSATGR RSADIGVPDK RVEFIQTDAA INPGNSGGPL
310 320 330 340 350
LNADGQVIGM NTAIIQNAQG IGFAIPINKA QEIAQQLIAT GKVEHAYLGI
360 370 380 390 400
QMVTMTPELQ SQIRQETGMN IPVDKGVVIM QVMPNSPAAI AKLEQGDVLQ
410 420 430 440 450
SLQGQPVENA EQVQSLVGKL AVGDEVELGI LRNGQQQNLT VTIGALPSAP

PQ
Length:452
Mass (Da):47,656
Last modified:February 1, 1997 - v1
Checksum:iAED4AFB1AC472361
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17385.1.
PIRiS77538.

Genome annotation databases

EnsemblBacteriaiBAA17385; BAA17385; BAA17385.
KEGGisyn:slr1204.
PATRICi23838618. VBISynSp132158_0876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17385.1.
PIRiS77538.

3D structure databases

ProteinModelPortaliP73354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP73354. 22 interactions.

Protein family/group databases

MEROPSiS01.482.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17385; BAA17385; BAA17385.
KEGGisyn:slr1204.
PATRICi23838618. VBISynSp132158_0876.

Phylogenomic databases

HOGENOMiHOG000223641.
InParanoidiP73354.
OMAiNQIGAPD.
OrthoDBiEOG61ZTDN.
PhylomeDBiP73354.

Enzyme and pathway databases

BioCyciSSP1148:GJOT-819-MONOMER.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  2. "Isolation of outer membrane of Synechocystis sp. PCC 6803 and its proteomic characterization."
    Huang F., Hedman E., Funk C., Kieselbach T., Schroder W.P., Norling B.
    Mol. Cell. Proteomics 3:586-595(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION IN OUTER MEMBRANE.
    Strain: PCC 6803 / Kazusa.
  3. "The deg proteases protect Synechocystis sp. PCC 6803 during heat and light stresses but are not essential for removal of damaged D1 protein during the photosystem two repair cycle."
    Barker M., de Vries R., Nield J., Komenda J., Nixon P.J.
    J. Biol. Chem. 281:30347-30355(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOTOPROTECTION, PROTECTION AGAINST HEAT STRESS, DISRUPTION PHENOTYPE.
    Strain: PCC 6803 / Kazusa.
  4. "The role of the FtsH and Deg proteases in the repair of UV-B radiation-damaged Photosystem II in the cyanobacterium Synechocystis PCC 6803."
    Cheregi O., Sicora C., Kos P.B., Barker M., Nixon P.J., Vass I.
    Biochim. Biophys. Acta 1767:820-828(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, DISRUPTION PHENOTYPE.
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiHTRA_SYNY3
AccessioniPrimary (citable) accession number: P73354
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: February 1, 1997
Last modified: March 16, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.