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P73302

- KAD1_SYNY3

UniProt

P73302 - KAD1_SYNY3

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Protein
Adenylate kinase 1
Gene
adk1, sll1815
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism By similarity.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331AMP By similarity
Binding sitei38 – 381AMP By similarity
Binding sitei94 – 941AMP By similarity
Binding sitei129 – 1291ATP By similarity
Binding sitei131 – 1311AMP By similarity
Binding sitei142 – 1421AMP By similarity
Binding sitei170 – 1701ATP; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176ATP By similarity
Nucleotide bindingi59 – 613AMP By similarity
Nucleotide bindingi87 – 904AMP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. adenylate kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. AMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00588; UER00649.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase 1 (EC:2.7.4.3)
Short name:
AK 1
Alternative name(s):
ATP-AMP transphosphorylase 1
ATP:AMP phosphotransferase 1
Adenylate monophosphate kinase 1
Gene namesi
Name:adk1
Ordered Locus Names:sll1815
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Adenylate kinase 1UniRule annotation
PRO_0000158871Add
BLAST

Proteomic databases

PaxDbiP73302.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi1148.sll1815.

Structurei

3D structure databases

ProteinModelPortaliP73302.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 6130NMPbind By similarity
Add
BLAST
Regioni128 – 1347LID By similarity

Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the adenylate kinase family.

Phylogenomic databases

eggNOGiCOG0563.
HOGENOMiHOG000238772.
KOiK00939.
OMAiQAKFIME.
OrthoDBiEOG679TH4.
PhylomeDBiP73302.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00235. Adenylate_kinase_Adk.
InterProiIPR006259. Adenyl_kin_sub.
IPR000850. Adenylat/UMP-CMP_kin.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01351. adk. 1 hit.
PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73302-1 [UniParc]FASTAAdd to Basket

« Hide

MAKGLIFLGA PGSGKGTQAV GLAETLGIPH ISTGDMLRQA IADGTELGNQ    50
AKGYMDKGEL VPDQLILGLI EERLGHKDAK AGWILDGFPR NVNQAIFLDE 100
LLVNIGHRTH WVINLKVPDE VIVERLLARG RADDNETTIR NRLLVYTEQT 150
APLMAYYQEQ GKLYSLDGNQ PVEAIATNLE KLVKP 185
Length:185
Mass (Da):20,251
Last modified:May 30, 2000 - v2
Checksum:i5A7C17202C9E8BF6
GO

Sequence cautioni

The sequence BAA17330.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17330.1. Different initiation.
PIRiS77483.
RefSeqiNP_440650.1. NC_000911.1.
YP_005650709.1. NC_017277.1.
YP_007450533.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17330; BAA17330; BAA17330.
GeneIDi953953.
KEGGisyn:sll1815.
syy:SYNGTS_0756.
syz:MYO_17610.
PATRICi23838504. VBISynSp132158_0819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17330.1 . Different initiation.
PIRi S77483.
RefSeqi NP_440650.1. NC_000911.1.
YP_005650709.1. NC_017277.1.
YP_007450533.1. NC_020286.1.

3D structure databases

ProteinModelPortali P73302.
ModBasei Search...

Protein-protein interaction databases

STRINGi 1148.sll1815.

Proteomic databases

PaxDbi P73302.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17330 ; BAA17330 ; BAA17330 .
GeneIDi 953953.
KEGGi syn:sll1815.
syy:SYNGTS_0756.
syz:MYO_17610.
PATRICi 23838504. VBISynSp132158_0819.

Phylogenomic databases

eggNOGi COG0563.
HOGENOMi HOG000238772.
KOi K00939.
OMAi QAKFIME.
OrthoDBi EOG679TH4.
PhylomeDBi P73302.

Enzyme and pathway databases

UniPathwayi UPA00588 ; UER00649 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00235. Adenylate_kinase_Adk.
InterProi IPR006259. Adenyl_kin_sub.
IPR000850. Adenylat/UMP-CMP_kin.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR23359. PTHR23359. 1 hit.
PRINTSi PR00094. ADENYLTKNASE.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01351. adk. 1 hit.
PROSITEi PS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiKAD1_SYNY3
AccessioniPrimary (citable) accession number: P73302
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

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