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P73302

- KAD1_SYNY3

UniProt

P73302 - KAD1_SYNY3

Protein

Adenylate kinase 1

Gene

adk1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.UniRule annotation

    Catalytic activityi

    ATP + AMP = 2 ADP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331AMPUniRule annotation
    Binding sitei38 – 381AMPUniRule annotation
    Binding sitei94 – 941AMPUniRule annotation
    Binding sitei129 – 1291ATPUniRule annotation
    Binding sitei131 – 1311AMPUniRule annotation
    Binding sitei142 – 1421AMPUniRule annotation
    Binding sitei170 – 1701ATP; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 176ATPUniRule annotation
    Nucleotide bindingi59 – 613AMPUniRule annotation
    Nucleotide bindingi87 – 904AMPUniRule annotation

    GO - Molecular functioni

    1. adenylate kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. AMP salvage Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00588; UER00649.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate kinase 1UniRule annotation (EC:2.7.4.3UniRule annotation)
    Short name:
    AK 1UniRule annotation
    Alternative name(s):
    ATP-AMP transphosphorylase 1UniRule annotation
    ATP:AMP phosphotransferase 1UniRule annotation
    Adenylate monophosphate kinase 1UniRule annotation
    Gene namesi
    Name:adk1UniRule annotation
    Ordered Locus Names:sll1815
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Adenylate kinase 1PRO_0000158871Add
    BLAST

    Proteomic databases

    PaxDbiP73302.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi1148.sll1815.

    Structurei

    3D structure databases

    ProteinModelPortaliP73302.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni32 – 6130NMPbindUniRule annotationAdd
    BLAST
    Regioni128 – 1347LIDUniRule annotation

    Domaini

    Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.UniRule annotation

    Sequence similaritiesi

    Belongs to the adenylate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0563.
    HOGENOMiHOG000238772.
    KOiK00939.
    OMAiQAKFIME.
    OrthoDBiEOG679TH4.
    PhylomeDBiP73302.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00235. Adenylate_kinase_Adk.
    InterProiIPR006259. Adenyl_kin_sub.
    IPR000850. Adenylat/UMP-CMP_kin.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR23359. PTHR23359. 1 hit.
    PRINTSiPR00094. ADENYLTKNASE.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01351. adk. 1 hit.
    PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73302-1 [UniParc]FASTAAdd to Basket

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    MAKGLIFLGA PGSGKGTQAV GLAETLGIPH ISTGDMLRQA IADGTELGNQ    50
    AKGYMDKGEL VPDQLILGLI EERLGHKDAK AGWILDGFPR NVNQAIFLDE 100
    LLVNIGHRTH WVINLKVPDE VIVERLLARG RADDNETTIR NRLLVYTEQT 150
    APLMAYYQEQ GKLYSLDGNQ PVEAIATNLE KLVKP 185
    Length:185
    Mass (Da):20,251
    Last modified:May 30, 2000 - v2
    Checksum:i5A7C17202C9E8BF6
    GO

    Sequence cautioni

    The sequence BAA17330.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17330.1. Different initiation.
    PIRiS77483.
    RefSeqiNP_440650.1. NC_000911.1.
    YP_005650709.1. NC_017277.1.
    YP_007450533.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17330; BAA17330; BAA17330.
    GeneIDi953953.
    KEGGisyn:sll1815.
    syy:SYNGTS_0756.
    syz:MYO_17610.
    PATRICi23838504. VBISynSp132158_0819.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17330.1 . Different initiation.
    PIRi S77483.
    RefSeqi NP_440650.1. NC_000911.1.
    YP_005650709.1. NC_017277.1.
    YP_007450533.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.sll1815.

    Proteomic databases

    PaxDbi P73302.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17330 ; BAA17330 ; BAA17330 .
    GeneIDi 953953.
    KEGGi syn:sll1815.
    syy:SYNGTS_0756.
    syz:MYO_17610.
    PATRICi 23838504. VBISynSp132158_0819.

    Phylogenomic databases

    eggNOGi COG0563.
    HOGENOMi HOG000238772.
    KOi K00939.
    OMAi QAKFIME.
    OrthoDBi EOG679TH4.
    PhylomeDBi P73302.

    Enzyme and pathway databases

    UniPathwayi UPA00588 ; UER00649 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00235. Adenylate_kinase_Adk.
    InterProi IPR006259. Adenyl_kin_sub.
    IPR000850. Adenylat/UMP-CMP_kin.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR23359. PTHR23359. 1 hit.
    PRINTSi PR00094. ADENYLTKNASE.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01351. adk. 1 hit.
    PROSITEi PS00113. ADENYLATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiKAD1_SYNY3
    AccessioniPrimary (citable) accession number: P73302
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3