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P73302 (KAD1_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenylate kinase 1

Short name=AK 1
EC=2.7.4.3
Alternative name(s):
ATP-AMP transphosphorylase 1
ATP:AMP phosphotransferase 1
Adenylate monophosphate kinase 1
Gene names
Name:adk1
Ordered Locus Names:sll1815
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism By similarity. HAMAP-Rule MF_00235

Catalytic activity

ATP + AMP = 2 ADP. HAMAP-Rule MF_00235

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP-Rule MF_00235

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00235

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00235.

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis By similarity. HAMAP-Rule MF_00235

Sequence similarities

Belongs to the adenylate kinase family.

Sequence caution

The sequence BAA17330.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processAMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

nucleotide phosphorylation

Inferred from electronic annotation. Source: GOC

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

adenylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Adenylate kinase 1 HAMAP-Rule MF_00235
PRO_0000158871

Regions

Nucleotide binding12 – 176ATP By similarity
Nucleotide binding59 – 613AMP By similarity
Nucleotide binding87 – 904AMP By similarity
Region32 – 6130NMPbind By similarity
Region128 – 1347LID By similarity

Sites

Binding site331AMP By similarity
Binding site381AMP By similarity
Binding site941AMP By similarity
Binding site1291ATP By similarity
Binding site1311AMP By similarity
Binding site1421AMP By similarity
Binding site1701ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P73302 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 5A7C17202C9E8BF6

FASTA18520,251
        10         20         30         40         50         60 
MAKGLIFLGA PGSGKGTQAV GLAETLGIPH ISTGDMLRQA IADGTELGNQ AKGYMDKGEL 

        70         80         90        100        110        120 
VPDQLILGLI EERLGHKDAK AGWILDGFPR NVNQAIFLDE LLVNIGHRTH WVINLKVPDE 

       130        140        150        160        170        180 
VIVERLLARG RADDNETTIR NRLLVYTEQT APLMAYYQEQ GKLYSLDGNQ PVEAIATNLE 


KLVKP 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA17330.1. Different initiation.
PIRS77483.
RefSeqNP_440650.1. NC_000911.1.
YP_005650709.1. NC_017277.1.
YP_007450533.1. NC_020286.1.

3D structure databases

ProteinModelPortalP73302.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1148.sll1815.

Proteomic databases

PaxDbP73302.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17330; BAA17330; BAA17330.
GeneID12256401.
14616183.
953953.
KEGGsyn:sll1815.
syy:SYNGTS_0756.
syz:MYO_17610.
PATRIC23838504. VBISynSp132158_0819.

Phylogenomic databases

eggNOGCOG0563.
HOGENOMHOG000238772.
KOK00939.
OMANEKMNAP.
OrthoDBEOG679TH4.
ProtClustDBPRK02496.

Enzyme and pathway databases

UniPathwayUPA00588; UER00649.

Family and domain databases

HAMAPMF_00235. Adenylate_kinase_Adk.
InterProIPR006259. Adenyl_kin_sub.
IPR000850. Adenylat/UMP-CMP_kin.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR23359. PTHR23359. 1 hit.
PRINTSPR00094. ADENYLTKNASE.
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01351. adk. 1 hit.
PROSITEPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAD1_SYNY3
AccessionPrimary (citable) accession number: P73302
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: February 19, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways