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P73283

- FABF_SYNY3

UniProt

P73283 - FABF_SYNY3

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

fabF

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates.

    Catalytic activityi

    (Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei167 – 1671

    GO - Molecular functioni

    1. beta-ketoacyl-acyl-carrier-protein synthase II activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179)
    Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase II
    Beta-ketoacyl-ACP synthase II
    Short name:
    KAS II
    Gene namesi
    Name:fabF
    Ordered Locus Names:sll1069
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4164163-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180326Add
    BLAST

    Proteomic databases

    PaxDbiP73283.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi1148.sll1069.

    Structurei

    Secondary structure

    1
    416
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi9 – 1810
    Beta strandi21 – 233
    Helixi24 – 329
    Beta strandi38 – 403
    Beta strandi53 – 553
    Helixi62 – 643
    Helixi68 – 725
    Helixi76 – 9217
    Turni98 – 1003
    Helixi101 – 1033
    Beta strandi104 – 1096
    Helixi115 – 12814
    Helixi130 – 1323
    Helixi137 – 1415
    Helixi145 – 15410
    Helixi166 – 1683
    Helixi169 – 18214
    Beta strandi187 – 1959
    Helixi200 – 2089
    Helixi219 – 2213
    Beta strandi238 – 2469
    Helixi247 – 2526
    Beta strandi259 – 26810
    Beta strandi273 – 2753
    Helixi281 – 29414
    Helixi298 – 3003
    Beta strandi303 – 3053
    Helixi312 – 32615
    Helixi327 – 3326
    Beta strandi333 – 3364
    Helixi339 – 3424
    Helixi346 – 3483
    Helixi349 – 36315
    Beta strandi373 – 3753
    Beta strandi385 – 3873
    Beta strandi394 – 4029
    Turni403 – 4053
    Beta strandi406 – 4138

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1E5MX-ray1.54A1-416[»]
    ProteinModelPortaliP73283.
    SMRiP73283. Positions 6-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP73283.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG0304.
    HOGENOMiHOG000060166.
    KOiK09458.
    OMAiNPDEVQY.
    OrthoDBiEOG6DG2SR.
    PhylomeDBiP73283.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000447. KAS_II. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    TIGRFAMsiTIGR03150. fabF. 1 hit.
    PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73283-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANLEKKRVV VTGLGAITPI GNTLQDYWQG LMEGRNGIGP ITRFDASDQA    50
    CRFGGEVKDF DATQFLDRKE AKRMDRFCHF AVCASQQAIN DAKLVINELN 100
    ADEIGVLIGT GIGGLKVLED QQTILLDKGP SRCSPFMIPM MIANMASGLT 150
    AINLGAKGPN NCTVTACAAG SNAIGDAFRL VQNGYAKAMI CGGTEAAITP 200
    LSYAGFASAR ALSFRNDDPL HASRPFDKDR DGFVMGEGSG ILILEELESA 250
    LARGAKIYGE MVGYAMTCDA YHITAPVPDG RGATRAIAWA LKDSGLKPEM 300
    VSYINAHGTS TPANDVTETR AIKQALGNHA YNIAVSSTKS MTGHLLGGSG 350
    GIEAVATVMA IAEDKVPPTI NLENPDPECD LDYVPGQSRA LIVDVALSNS 400
    FGFGGHNVTL AFKKYQ 416
    Length:416
    Mass (Da):44,004
    Last modified:February 1, 1997 - v1
    Checksum:iB0740A438A91A6C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17311.1.
    PIRiS77464.
    RefSeqiNP_440631.1. NC_000911.1.
    YP_005650690.1. NC_017277.1.
    YP_007450514.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17311; BAA17311; BAA17311.
    GeneIDi953934.
    KEGGisyn:sll1069.
    syy:SYNGTS_0737.
    syz:MYO_17420.
    PATRICi23838460. VBISynSp132158_0797.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17311.1 .
    PIRi S77464.
    RefSeqi NP_440631.1. NC_000911.1.
    YP_005650690.1. NC_017277.1.
    YP_007450514.1. NC_020286.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1E5M X-ray 1.54 A 1-416 [» ]
    ProteinModelPortali P73283.
    SMRi P73283. Positions 6-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.sll1069.

    Proteomic databases

    PaxDbi P73283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17311 ; BAA17311 ; BAA17311 .
    GeneIDi 953934.
    KEGGi syn:sll1069.
    syy:SYNGTS_0737.
    syz:MYO_17420.
    PATRICi 23838460. VBISynSp132158_0797.

    Phylogenomic databases

    eggNOGi COG0304.
    HOGENOMi HOG000060166.
    KOi K09458.
    OMAi NPDEVQY.
    OrthoDBi EOG6DG2SR.
    PhylomeDBi P73283.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Miscellaneous databases

    EvolutionaryTracei P73283.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000447. KAS_II. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    TIGRFAMsi TIGR03150. fabF. 1 hit.
    PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.
    2. "The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 A resolution and its relationship to other condensing enzymes."
      Moche M., Dehesh K., Edwards P., Lindqvist Y.
      J. Mol. Biol. 305:491-503(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS).

    Entry informationi

    Entry nameiFABF_SYNY3
    AccessioniPrimary (citable) accession number: P73283
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3