Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P73283 (FABF_SYNY3)

Last modified December 15, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 2
    EC=2.3.1.179
Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase II
    Beta-ketoacyl-ACP synthase II
      Short name=KAS II
Gene names
Name: fabF
Ordered Locus Names: sll1069
OrganismSynechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]
Taxonomic identifier1148 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaChroococcalesSynechocystis

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates.

Catalytic activity

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4164163-oxoacyl-[acyl-carrier-protein] synthase 2
PRO_0000180326

Sites

Active site1671

Secondary structure

................................................................... 416
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P73283-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: B0740A438A91A6C1

FASTA41644,004
        10         20         30         40         50         60 
MANLEKKRVV VTGLGAITPI GNTLQDYWQG LMEGRNGIGP ITRFDASDQA CRFGGEVKDF 

        70         80         90        100        110        120 
DATQFLDRKE AKRMDRFCHF AVCASQQAIN DAKLVINELN ADEIGVLIGT GIGGLKVLED 

       130        140        150        160        170        180 
QQTILLDKGP SRCSPFMIPM MIANMASGLT AINLGAKGPN NCTVTACAAG SNAIGDAFRL 

       190        200        210        220        230        240 
VQNGYAKAMI CGGTEAAITP LSYAGFASAR ALSFRNDDPL HASRPFDKDR DGFVMGEGSG 

       250        260        270        280        290        300 
ILILEELESA LARGAKIYGE MVGYAMTCDA YHITAPVPDG RGATRAIAWA LKDSGLKPEM 

       310        320        330        340        350        360 
VSYINAHGTS TPANDVTETR AIKQALGNHA YNIAVSSTKS MTGHLLGGSG GIEAVATVMA 

       370        380        390        400        410 
IAEDKVPPTI NLENPDPECD LDYVPGQSRA LIVDVALSNS FGFGGHNVTL AFKKYQ 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 A resolution and its relationship to other condensing enzymes."
Moche M., Dehesh K., Edwards P., Lindqvist Y.
J. Mol. Biol. 305:491-503(2001) [PubMed: 11152607] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS).

Cross-references

Sequence databases

BA000022 Genomic DNA. Translation: BAA17311.1.
PIRS77464.
RefSeqNP_440631.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1E5MX-ray1.54A1-416[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGP73283.

Genome annotation databases

GeneID953934.
GenomeReviewsGene locus sll1069 in contig BA000022_GR.
KEGGsyn:sll1069.
NMPDRfig|1148.1.peg.732.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG757733.
OMANNIDEYL.

Enzyme and pathway databases

BioCycSSP1148:SLL1069-MON.

Family and domain databases

InterProIPR017568. 3-oxoacyl-ACP_synth-2.
IPR000794. Beta-ketoacyl_synthase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PANTHERPTHR11712. Ketoacyl_synth. 1 hit.
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PROSITEPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABF_SYNY3
AccessionPrimary (citable) accession number: P73283
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: February 1, 1997
Last modified: December 15, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents