3-oxoacyl-[acyl-carrier-protein] synthase 2 - Synechocystis sp. (strain PCC 6803)

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Reviewed, UniProtKB/Swiss-Prot P73283 (FABF_SYNY3)

Last modified December 15, 2009. Version 69. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 2
    EC=2.3.1.179
Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase II
    Beta-ketoacyl-ACP synthase II
      Short name=KAS II

Gene names

Name:	fabF
Ordered Locus Names:	sll1069

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

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Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates.
Catalytic activity	(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO₂ + [acyl-carrier-protein].
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the beta-ketoacyl-ACP synthases family.

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Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Molecular function	Acyltransferase Transferase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW beta-ketoacyl-acyl-carrier-protein synthase II activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 416

416

3-oxoacyl-[acyl-carrier-protein] synthase 2

PRO_0000180326

Sites

Active site

167

Secondary structure

416

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P73283-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: B0740A438A91A6C1
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FASTA

416

44,004

        10         20         30         40         50         60 
MANLEKKRVV VTGLGAITPI GNTLQDYWQG LMEGRNGIGP ITRFDASDQA CRFGGEVKDF 

        70         80         90        100        110        120 
DATQFLDRKE AKRMDRFCHF AVCASQQAIN DAKLVINELN ADEIGVLIGT GIGGLKVLED 

       130        140        150        160        170        180 
QQTILLDKGP SRCSPFMIPM MIANMASGLT AINLGAKGPN NCTVTACAAG SNAIGDAFRL 

       190        200        210        220        230        240 
VQNGYAKAMI CGGTEAAITP LSYAGFASAR ALSFRNDDPL HASRPFDKDR DGFVMGEGSG 

       250        260        270        280        290        300 
ILILEELESA LARGAKIYGE MVGYAMTCDA YHITAPVPDG RGATRAIAWA LKDSGLKPEM 

       310        320        330        340        350        360 
VSYINAHGTS TPANDVTETR AIKQALGNHA YNIAVSSTKS MTGHLLGGSG GIEAVATVMA 

       370        380        390        400        410 
IAEDKVPPTI NLENPDPECD LDYVPGQSRA LIVDVALSNS FGFGGHNVTL AFKKYQ

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 A resolution and its relationship to other condensing enzymes." Moche M., Dehesh K., Edwards P., Lindqvist Y. J. Mol. Biol. 305:491-503(2001) [PubMed: 11152607] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS).

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Cross-references

Sequence databases

BA000022 Genomic DNA. Translation: BAA17311.1.

PIR

S77464.

RefSeq

NP_440631.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1E5M	X-ray	1.54	A	1-416	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

P73283.

Genome annotation databases

GeneID

953934.

GenomeReviews

Gene locus sll1069 in contig BA000022_GR.

KEGG

syn:sll1069.

NMPDR

fig|1148.1.peg.732.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

HBG757733.

OMA

NNIDEYL.

Enzyme and pathway databases

BioCyc

SSP1148:SLL1069-MON.

Family and domain databases

InterPro

IPR017568. 3-oxoacyl-ACP_synth-2.
IPR000794. Beta-ketoacyl_synthase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]

Gene3D

G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.

PANTHER

PTHR11712. Ketoacyl_synth. 1 hit.

Pfam

PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]

PROSITE

PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

ProtoNet

Search...

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Entry information

Entry name

FABF_SYNY3

Accession

Primary (citable) accession number: P73283

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	February 1, 1997
Last modified:	December 15, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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