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P73283

- FABF_SYNY3

UniProt

P73283 - FABF_SYNY3

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Protein
3-oxoacyl-[acyl-carrier-protein] synthase 2
Gene
fabF, sll1069
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates.

Catalytic activityi

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei167 – 1671

GO - Molecular functioni

  1. beta-ketoacyl-acyl-carrier-protein synthase II activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase II
Beta-ketoacyl-ACP synthase II
Short name:
KAS II
Gene namesi
Name:fabF
Ordered Locus Names:sll1069
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4164163-oxoacyl-[acyl-carrier-protein] synthase 2
PRO_0000180326Add
BLAST

Proteomic databases

PaxDbiP73283.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi1148.sll1069.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 1810
Beta strandi21 – 233
Helixi24 – 329
Beta strandi38 – 403
Beta strandi53 – 553
Helixi62 – 643
Helixi68 – 725
Helixi76 – 9217
Turni98 – 1003
Helixi101 – 1033
Beta strandi104 – 1096
Helixi115 – 12814
Helixi130 – 1323
Helixi137 – 1415
Helixi145 – 15410
Helixi166 – 1683
Helixi169 – 18214
Beta strandi187 – 1959
Helixi200 – 2089
Helixi219 – 2213
Beta strandi238 – 2469
Helixi247 – 2526
Beta strandi259 – 26810
Beta strandi273 – 2753
Helixi281 – 29414
Helixi298 – 3003
Beta strandi303 – 3053
Helixi312 – 32615
Helixi327 – 3326
Beta strandi333 – 3364
Helixi339 – 3424
Helixi346 – 3483
Helixi349 – 36315
Beta strandi373 – 3753
Beta strandi385 – 3873
Beta strandi394 – 4029
Turni403 – 4053
Beta strandi406 – 4138

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E5MX-ray1.54A1-416[»]
ProteinModelPortaliP73283.
SMRiP73283. Positions 6-416.

Miscellaneous databases

EvolutionaryTraceiP73283.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060166.
KOiK09458.
OMAiNPDEVQY.
OrthoDBiEOG6DG2SR.
PhylomeDBiP73283.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000447. KAS_II. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR03150. fabF. 1 hit.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73283-1 [UniParc]FASTAAdd to Basket

« Hide

MANLEKKRVV VTGLGAITPI GNTLQDYWQG LMEGRNGIGP ITRFDASDQA    50
CRFGGEVKDF DATQFLDRKE AKRMDRFCHF AVCASQQAIN DAKLVINELN 100
ADEIGVLIGT GIGGLKVLED QQTILLDKGP SRCSPFMIPM MIANMASGLT 150
AINLGAKGPN NCTVTACAAG SNAIGDAFRL VQNGYAKAMI CGGTEAAITP 200
LSYAGFASAR ALSFRNDDPL HASRPFDKDR DGFVMGEGSG ILILEELESA 250
LARGAKIYGE MVGYAMTCDA YHITAPVPDG RGATRAIAWA LKDSGLKPEM 300
VSYINAHGTS TPANDVTETR AIKQALGNHA YNIAVSSTKS MTGHLLGGSG 350
GIEAVATVMA IAEDKVPPTI NLENPDPECD LDYVPGQSRA LIVDVALSNS 400
FGFGGHNVTL AFKKYQ 416
Length:416
Mass (Da):44,004
Last modified:February 1, 1997 - v1
Checksum:iB0740A438A91A6C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17311.1.
PIRiS77464.
RefSeqiNP_440631.1. NC_000911.1.
YP_005650690.1. NC_017277.1.
YP_007450514.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17311; BAA17311; BAA17311.
GeneIDi953934.
KEGGisyn:sll1069.
syy:SYNGTS_0737.
syz:MYO_17420.
PATRICi23838460. VBISynSp132158_0797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17311.1 .
PIRi S77464.
RefSeqi NP_440631.1. NC_000911.1.
YP_005650690.1. NC_017277.1.
YP_007450514.1. NC_020286.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1E5M X-ray 1.54 A 1-416 [» ]
ProteinModelPortali P73283.
SMRi P73283. Positions 6-416.
ModBasei Search...

Protein-protein interaction databases

STRINGi 1148.sll1069.

Proteomic databases

PaxDbi P73283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17311 ; BAA17311 ; BAA17311 .
GeneIDi 953934.
KEGGi syn:sll1069.
syy:SYNGTS_0737.
syz:MYO_17420.
PATRICi 23838460. VBISynSp132158_0797.

Phylogenomic databases

eggNOGi COG0304.
HOGENOMi HOG000060166.
KOi K09458.
OMAi NPDEVQY.
OrthoDBi EOG6DG2SR.
PhylomeDBi P73283.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Miscellaneous databases

EvolutionaryTracei P73283.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000447. KAS_II. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
TIGRFAMsi TIGR03150. fabF. 1 hit.
PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  2. "The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 A resolution and its relationship to other condensing enzymes."
    Moche M., Dehesh K., Edwards P., Lindqvist Y.
    J. Mol. Biol. 305:491-503(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS).

Entry informationi

Entry nameiFABF_SYNY3
AccessioniPrimary (citable) accession number: P73283
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

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