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P73274

- SYL_SYNY3

UniProt

P73274 - SYL_SYNY3

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei625 – 6251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:sll1074
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 869869Leucine--tRNA ligasePRO_0000152105Add
    BLAST

    Proteomic databases

    PaxDbiP73274.

    Interactioni

    Protein-protein interaction databases

    STRINGi1148.sll1074.

    Structurei

    3D structure databases

    ProteinModelPortaliP73274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi622 – 6265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.
    PhylomeDBiP73274.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73274-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPYNAGEI EQKWQQRWAE WGLDKTPIAS DLPKFYALSM FPYPSGNLHM    50
    GHVRNYTITD VIARLKRMQG YQVLHPMGWD AFGLPAENAA IERGIPPKQW 100
    TEKNIAQMRA QLQQLGLSID WEREVATCAP DYYRWTQWLF LEFFQAGLAY 150
    QKEATVNWDP IDQTVLANEQ VDSEGRSWRS GAMVERKLLR QWFLKITDYA 200
    EALLNDLEQL TGWPERVKLM QSHWIGKSVG AYLEFPIKDS QEKIAVFTTR 250
    PDTVYGVTYV VLAPEHPLTK VVTTAEQQGT VDEFVAMVAK ESEIERTAED 300
    KPKRGVKTGG IAINPFNGEE IPILIADYVL YEYGTGAVMG VPAHDQRDFK 350
    FAQDNNLPMQ VVIIPDDADN SDVNLTVAYT EAGVMVNSAQ FTGMASPKAK 400
    QAIIKFAEDN DYGRAKVQYR LRDWLISRQR YWGCPIPIIH CDDCGAVPVP 450
    TKDLPVELPD NVEFSGRGPS PLAKLEDWIN VPCPSCGKPA RRETDTMDTF 500
    IDSSWYFLRY ADAQNTELPF DGEKVAHWLP VDQYVGGIEH AILHLLYSRF 550
    FTKVLADRQL IPVKEPFQKL LTQGMVQGIT YKNPTTGKYV PAKDLQTGQQ 600
    VIDPKDPKDP DSGEPLQVFY EKMSKSKFNG VDPQEVLAKY GADTARMFIL 650
    FKAPPEKDLE WDDADVEGQF RFLNRVWRLV TDYIGDPAGI RFAVRPETLV 700
    TNEPLTKAEK DLRRAIHGAI KEVAEDLNDD YQFNTAISEM MKLSNALIAA 750
    TDLISFPVYQ EGIETLLLLL APFAPHLTEE LWHRLGRTDS IHQQAWLQVD 800
    PTALVLDEIT LVIQVLGKTR GTITVPASAD KTQLEELARN SDLAQRYLEG 850
    KTIKKVIVVP GKLVNFVIT 869
    Length:869
    Mass (Da):98,295
    Last modified:February 1, 1997 - v1
    Checksum:i09D9380506F08D16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17302.1.
    PIRiS77455.
    RefSeqiNP_440622.1. NC_000911.1.
    YP_005650680.1. NC_017277.1.
    YP_007450505.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17302; BAA17302; BAA17302.
    GeneIDi953925.
    KEGGisyn:sll1074.
    syy:SYNGTS_0727.
    syz:MYO_17330.
    PATRICi23838442. VBISynSp132158_0788.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17302.1 .
    PIRi S77455.
    RefSeqi NP_440622.1. NC_000911.1.
    YP_005650680.1. NC_017277.1.
    YP_007450505.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.sll1074.

    Proteomic databases

    PaxDbi P73274.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17302 ; BAA17302 ; BAA17302 .
    GeneIDi 953925.
    KEGGi syn:sll1074.
    syy:SYNGTS_0727.
    syz:MYO_17330.
    PATRICi 23838442. VBISynSp132158_0788.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.
    PhylomeDBi P73274.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiSYL_SYNY3
    AccessioniPrimary (citable) accession number: P73274
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3