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Protein

Probable agmatinase 2

Gene

speB2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Mn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi174 – 1741ManganesePROSITE-ProRule annotation
Metal bindingi199 – 1991ManganesePROSITE-ProRule annotation
Metal bindingi201 – 2011ManganesePROSITE-ProRule annotation
Metal bindingi203 – 2031ManganesePROSITE-ProRule annotation
Metal bindingi291 – 2911ManganesePROSITE-ProRule annotation
Metal bindingi293 – 2931ManganesePROSITE-ProRule annotation

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. putrescine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Putrescine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable agmatinase 2 (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase 2
Short name:
AUH 2
Gene namesi
Name:speB2
Ordered Locus Names:sll1077
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Probable agmatinase 2PRO_0000173745Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP73270. 1 interaction.
STRINGi1148.sll1077.

Structurei

3D structure databases

ProteinModelPortaliP73270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000224476.
InParanoidiP73270.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG6R2GW5.
PhylomeDBiP73270.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73270-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDATPFRPP SEAEEALIKE TRLPLTGWQQ EVDQGLTYGL EAAASIKDRS
60 70 80 90 100
IPTFSRGELP HYAGINTFMK APYLEDVREV GKYDVAIVGV PHDSGTTYRP
110 120 130 140 150
GTRFGPQGIR RISALYTPYN FEMGVDLREQ ISLCDVGDIF TIPANNEKSF
160 170 180 190 200
DQISKGIAHI FSSGAFPIIL GGDHSIGFPT VRGICRHLGD KKVGIIHFDR
210 220 230 240 250
HVDTQETDLD ERMHTCPWFH ATNMANAPAK NLVQLGIGGW QVPRQGVKVC
260 270 280 290 300
RERATNILTV TDITEMSLDA AADFAIARAT DGTDCVWISF DIDCIDAGFV
310 320 330 340 350
PGTGWPEPGG LLPREALYLL KRIIRETNVC GMEVVEVSPP YDISDMTSLM
360 370 380 390
ATRVICDTMA HLVVSGQLPR TEKPAYIHAE ANMAVDEPWQ
Length:390
Mass (Da):42,964
Last modified:February 1, 1997 - v1
Checksum:i7612DBDD6C29A133
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17298.1.
PIRiS77451.
RefSeqiNP_440618.1. NC_000911.1.
YP_005650676.1. NC_017277.1.
YP_007450501.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17298; BAA17298; BAA17298.
GeneIDi953921.
KEGGisyn:sll1077.
PATRICi23838432. VBISynSp132158_0783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17298.1.
PIRiS77451.
RefSeqiNP_440618.1. NC_000911.1.
YP_005650676.1. NC_017277.1.
YP_007450501.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP73270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP73270. 1 interaction.
STRINGi1148.sll1077.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17298; BAA17298; BAA17298.
GeneIDi953921.
KEGGisyn:sll1077.
PATRICi23838432. VBISynSp132158_0783.

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000224476.
InParanoidiP73270.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG6R2GW5.
PhylomeDBiP73270.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  2. "Arginine catabolism in the cyanobacterium Synechocystis sp. strain PCC 6803 involves the urea cycle and arginase pathway."
    Quintero M.J., Muro-Pastor A.M., Herrero A., Flores E.
    J. Bacteriol. 182:1008-1015(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSPEB2_SYNY3
AccessioniPrimary (citable) accession number: P73270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.