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Protein

Argininosuccinate lyase

Gene

argH

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:slr1133
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001378411 – 461Argininosuccinate lyaseAdd BLAST461

Proteomic databases

PaxDbiP73257
PRIDEiP73257

Interactioni

Protein-protein interaction databases

IntActiP73257, 1 interactor
STRINGi1148.SYNGTS_0709

Structurei

3D structure databases

ProteinModelPortaliP73257
SMRiP73257
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242744
InParanoidiP73257
KOiK01755
OMAiSIMPHKK
PhylomeDBiP73257

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

P73257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKTWSDRF EGTLHPAIAL FNASIGFDIE LIEYDLDGSI AHGKMLAKTG
60 70 80 90 100
IISPGEAEQL VQGLEQIRQE YRAGNFNPGV DQEDVHFAVE RRLTELVGDV
110 120 130 140 150
GKKLHTARSR NDQVGTDVRL YLRAQIDDIR QRLRDFQAVL LQLAETNVET
160 170 180 190 200
LIPGYTHLQR AQPVSLAHHL LAYFQMAQRD WQRLGEIRAR TNVSPLGSGA
210 220 230 240 250
LAGTTFPIDR HYSAELLGFA GVYANSLDGV SDRDFAIEFL NAASLIMVHL
260 270 280 290 300
SRLSEEMILW ASQEFSFISL TDSCATGSSI MPQKKNPDVP ELIRGKAGRV
310 320 330 340 350
MGHLQGMLVL MKGLPLAYNK DLQEDKEALF DAVKTVQVSL EAMTILLDEG
360 370 380 390 400
IVFRQERLAE AVAEDFSNAT DVADYLAAKG VPFREAYNLV GKVVKTSLAA
410 420 430 440 450
GKLLKDLTLA EWQALHPAFE EDIYQAITPQ QVVAARNSYG GTGFEQVKMA
460
IANAKAELSQ T
Length:461
Mass (Da):50,948
Last modified:February 1, 1997 - v1
Checksum:iB6E8C81B1CFB5FE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA17284.1
PIRiS77437

Genome annotation databases

EnsemblBacteriaiBAA17284; BAA17284; BAA17284
KEGGisyn:slr1133

Similar proteinsi

Entry informationi

Entry nameiARLY_SYNY3
AccessioniPrimary (citable) accession number: P73257
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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