P73257 (ARLY_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	slr1133

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP-Rule MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP-Rule MF_00006
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Argininosuccinate lyase HAMAP-Rule MF_00006		PRO_0000137841

Sequences

	Sequence		Length	Mass (Da)
	P73257 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: B6E8C81B1CFB5FE2	FASTA	461	50,948
	10 20 30 40 50 60 MTKKTWSDRF EGTLHPAIAL FNASIGFDIE LIEYDLDGSI AHGKMLAKTG IISPGEAEQL 70 80 90 100 110 120 VQGLEQIRQE YRAGNFNPGV DQEDVHFAVE RRLTELVGDV GKKLHTARSR NDQVGTDVRL 130 140 150 160 170 180 YLRAQIDDIR QRLRDFQAVL LQLAETNVET LIPGYTHLQR AQPVSLAHHL LAYFQMAQRD 190 200 210 220 230 240 WQRLGEIRAR TNVSPLGSGA LAGTTFPIDR HYSAELLGFA GVYANSLDGV SDRDFAIEFL 250 260 270 280 290 300 NAASLIMVHL SRLSEEMILW ASQEFSFISL TDSCATGSSI MPQKKNPDVP ELIRGKAGRV 310 320 330 340 350 360 MGHLQGMLVL MKGLPLAYNK DLQEDKEALF DAVKTVQVSL EAMTILLDEG IVFRQERLAE 370 380 390 400 410 420 AVAEDFSNAT DVADYLAAKG VPFREAYNLV GKVVKTSLAA GKLLKDLTLA EWQALHPAFE 430 440 450 460 EDIYQAITPQ QVVAARNSYG GTGFEQVKMA IANAKAELSQ T

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA17284.1.
PIR	S77437.
RefSeq	NP_440604.1. NC_000911.1. YP_005650662.1. NC_017277.1. YP_007450487.1. NC_020286.1.
3D structure databases
ProteinModelPortal	P73257.
SMR	P73257. Positions 16-459.
ModBase	Search...
Protein-protein interaction databases
IntAct	P73257. 1 interaction.
STRING	1148.slr1133.
Proteomic databases
PaxDb	P73257.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA17284; BAA17284; BAA17284.
GeneID	12256354. 14616137. 953907.
KEGG	syn:slr1133. syy:SYNGTS_0709.
PATRIC	23838402. VBISynSp132158_0768.
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HOG000242744.
KO	K01755.
OMA	KEGIFDA.
ProtClustDB	PRK00855.
Enzyme and pathway databases
UniPathway	UPA00068; UER00114.
Family and domain databases
Gene3D	1.10.275.10. 1 hit.
HAMAP	MF_00006. Arg_succ_lyase.
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR024083. Fumarase/histidase_N. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR022761. Fumarate_lyase_N. IPR008948. L-Aspartase-like. [Graphical view]
PANTHER	PTHR11444:SF3. PTHR11444:SF3. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_SYNY3

Accession

Primary (citable) accession number: P73257

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program