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P73248

- DHPS_SYNY3

UniProt

P73248 - DHPS_SYNY3

Protein

Dihydropteroate synthase

Gene

folP

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide By similarity.By similarity

    Catalytic activityi

    (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

    Cofactori

    Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi35 – 351MagnesiumBy similarity
    Binding sitei43 – 431SubstrateBy similarity
    Binding sitei109 – 1091SubstrateBy similarity
    Binding sitei128 – 1281SubstrateBy similarity
    Binding sitei199 – 1991SubstrateBy similarity
    Binding sitei235 – 2351SubstrateBy similarity
    Binding sitei270 – 2701SubstrateBy similarity
    Binding sitei272 – 2721SubstrateBy similarity

    GO - Molecular functioni

    1. dihydropteroate synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. response to antibiotic Source: UniProtKB-KW
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Antibiotic resistance, Folate biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00077; UER00156.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydropteroate synthase (EC:2.5.1.15)
    Short name:
    DHPS
    Alternative name(s):
    Dihydropteroate pyrophosphorylase
    Gene namesi
    Name:folP
    Ordered Locus Names:slr2026
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Dihydropteroate synthasePRO_0000168237Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiP73248. 2 interactions.
    STRINGi1148.slr2026.

    Structurei

    3D structure databases

    ProteinModelPortaliP73248.
    SMRiP73248. Positions 14-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 282255Pterin-bindingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni75 – 762Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the DHPS family.Curated
    Contains 1 pterin-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0294.
    HOGENOMiHOG000217509.
    KOiK00796.
    OMAiDMFYVAA.
    OrthoDBiEOG67T5P5.
    PhylomeDBiP73248.

    Family and domain databases

    Gene3Di3.20.20.20. 1 hit.
    InterProiIPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000489. Pterin-binding.
    [Graphical view]
    PfamiPF00809. Pterin_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF51717. SSF51717. 1 hit.
    TIGRFAMsiTIGR01496. DHPS. 1 hit.
    PROSITEiPS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73248-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQLDQLSDY FPPPLPVGQT LFDWGKRTYV MGILNTTPDS FSDGGEFNSL    50
    PTAIHQAKTM VQGGAHIIDI GGQSTRPGAE TVSLKEELER TIPIIQALRQ 100
    ELDIPISIDT TRAEVARQAL QAGADMVNDI SGATFEPEIL AVAAQHKAPI 150
    ILMHIRGNPQ TMQNLTDYGD LIGEMRQFFS AQVDLARHYG VLPEQIILDP 200
    GIGFAKTAEQ NITLLRQLPE LKRLGFPLLV GPSRKSFIGK ILDQPDPKER 250
    VWGTGATCCR AIAGGADIVR VHDVEAMAQI CKVADALWR 289
    Length:289
    Mass (Da):31,602
    Last modified:February 1, 1997 - v1
    Checksum:i76D28F8ACCEB9BA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17275.1.
    PIRiS75361.
    RefSeqiNP_440595.1. NC_000911.1.
    YP_005650653.1. NC_017277.1.
    YP_007450478.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17275; BAA17275; BAA17275.
    GeneIDi953898.
    KEGGisyn:slr2026.
    syy:SYNGTS_0700.
    syz:MYO_17060.
    PATRICi23838380. VBISynSp132158_0757.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17275.1 .
    PIRi S75361.
    RefSeqi NP_440595.1. NC_000911.1.
    YP_005650653.1. NC_017277.1.
    YP_007450478.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73248.
    SMRi P73248. Positions 14-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P73248. 2 interactions.
    STRINGi 1148.slr2026.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17275 ; BAA17275 ; BAA17275 .
    GeneIDi 953898.
    KEGGi syn:slr2026.
    syy:SYNGTS_0700.
    syz:MYO_17060.
    PATRICi 23838380. VBISynSp132158_0757.

    Phylogenomic databases

    eggNOGi COG0294.
    HOGENOMi HOG000217509.
    KOi K00796.
    OMAi DMFYVAA.
    OrthoDBi EOG67T5P5.
    PhylomeDBi P73248.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00156 .

    Family and domain databases

    Gene3Di 3.20.20.20. 1 hit.
    InterProi IPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000489. Pterin-binding.
    [Graphical view ]
    Pfami PF00809. Pterin_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51717. SSF51717. 1 hit.
    TIGRFAMsi TIGR01496. DHPS. 1 hit.
    PROSITEi PS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiDHPS_SYNY3
    AccessioniPrimary (citable) accession number: P73248
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3