Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P73248 (DHPS_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydropteroate synthase

Short name=DHPS
EC=2.5.1.15
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene names
Name:folP
Ordered Locus Names:slr2026
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide By similarity.

Catalytic activity

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactor

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

Sequence similarities

Belongs to the DHPS family.

Contains 1 pterin-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Dihydropteroate synthase
PRO_0000168237

Regions

Domain28 – 282255Pterin-binding
Region75 – 762Substrate binding By similarity

Sites

Metal binding351Magnesium By similarity
Binding site431Substrate By similarity
Binding site1091Substrate By similarity
Binding site1281Substrate By similarity
Binding site1991Substrate By similarity
Binding site2351Substrate By similarity
Binding site2701Substrate By similarity
Binding site2721Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P73248 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 76D28F8ACCEB9BA5

FASTA28931,602
        10         20         30         40         50         60 
MDQLDQLSDY FPPPLPVGQT LFDWGKRTYV MGILNTTPDS FSDGGEFNSL PTAIHQAKTM 

        70         80         90        100        110        120 
VQGGAHIIDI GGQSTRPGAE TVSLKEELER TIPIIQALRQ ELDIPISIDT TRAEVARQAL 

       130        140        150        160        170        180 
QAGADMVNDI SGATFEPEIL AVAAQHKAPI ILMHIRGNPQ TMQNLTDYGD LIGEMRQFFS 

       190        200        210        220        230        240 
AQVDLARHYG VLPEQIILDP GIGFAKTAEQ NITLLRQLPE LKRLGFPLLV GPSRKSFIGK 

       250        260        270        280 
ILDQPDPKER VWGTGATCCR AIAGGADIVR VHDVEAMAQI CKVADALWR 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA17275.1.
PIRS75361.
RefSeqNP_440595.1. NC_000911.1.
YP_005650653.1. NC_017277.1.
YP_007450478.1. NC_020286.1.

3D structure databases

ProteinModelPortalP73248.
SMRP73248. Positions 14-289.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP73248. 2 interactions.
STRING1148.slr2026.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17275; BAA17275; BAA17275.
GeneID953898.
KEGGsyn:slr2026.
syy:SYNGTS_0700.
syz:MYO_17060.
PATRIC23838380. VBISynSp132158_0757.

Phylogenomic databases

eggNOGCOG0294.
HOGENOMHOG000217509.
KOK00796.
OMADMFYVAA.
OrthoDBEOG67T5P5.
PhylomeDBP73248.

Enzyme and pathway databases

UniPathwayUPA00077; UER00156.

Family and domain databases

Gene3D3.20.20.20. 1 hit.
InterProIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMSSF51717. SSF51717. 1 hit.
TIGRFAMsTIGR01496. DHPS. 1 hit.
PROSITEPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHPS_SYNY3
AccessionPrimary (citable) accession number: P73248
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways