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P73248

- DHPS_SYNY3

UniProt

P73248 - DHPS_SYNY3

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Protein

Dihydropteroate synthase

Gene

folP

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide (By similarity).By similarity

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi35 – 351MagnesiumBy similarity
Binding sitei43 – 431SubstrateBy similarity
Binding sitei109 – 1091SubstrateBy similarity
Binding sitei128 – 1281SubstrateBy similarity
Binding sitei199 – 1991SubstrateBy similarity
Binding sitei235 – 2351SubstrateBy similarity
Binding sitei270 – 2701SubstrateBy similarity
Binding sitei272 – 2721SubstrateBy similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP
Ordered Locus Names:slr2026
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Dihydropteroate synthasePRO_0000168237Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP73248. 2 interactions.
STRINGi1148.slr2026.

Structurei

3D structure databases

ProteinModelPortaliP73248.
SMRiP73248. Positions 14-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 282255Pterin-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 762Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0294.
HOGENOMiHOG000217509.
InParanoidiP73248.
KOiK00796.
OMAiDMFYVAA.
OrthoDBiEOG67T5P5.
PhylomeDBiP73248.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73248-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQLDQLSDY FPPPLPVGQT LFDWGKRTYV MGILNTTPDS FSDGGEFNSL
60 70 80 90 100
PTAIHQAKTM VQGGAHIIDI GGQSTRPGAE TVSLKEELER TIPIIQALRQ
110 120 130 140 150
ELDIPISIDT TRAEVARQAL QAGADMVNDI SGATFEPEIL AVAAQHKAPI
160 170 180 190 200
ILMHIRGNPQ TMQNLTDYGD LIGEMRQFFS AQVDLARHYG VLPEQIILDP
210 220 230 240 250
GIGFAKTAEQ NITLLRQLPE LKRLGFPLLV GPSRKSFIGK ILDQPDPKER
260 270 280
VWGTGATCCR AIAGGADIVR VHDVEAMAQI CKVADALWR
Length:289
Mass (Da):31,602
Last modified:February 1, 1997 - v1
Checksum:i76D28F8ACCEB9BA5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17275.1.
PIRiS75361.
RefSeqiNP_440595.1. NC_000911.1.
YP_005650653.1. NC_017277.1.
YP_007450478.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17275; BAA17275; BAA17275.
GeneIDi953898.
KEGGisyn:slr2026.
syy:SYNGTS_0700.
syz:MYO_17060.
PATRICi23838380. VBISynSp132158_0757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17275.1 .
PIRi S75361.
RefSeqi NP_440595.1. NC_000911.1.
YP_005650653.1. NC_017277.1.
YP_007450478.1. NC_020286.1.

3D structure databases

ProteinModelPortali P73248.
SMRi P73248. Positions 14-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P73248. 2 interactions.
STRINGi 1148.slr2026.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17275 ; BAA17275 ; BAA17275 .
GeneIDi 953898.
KEGGi syn:slr2026.
syy:SYNGTS_0700.
syz:MYO_17060.
PATRICi 23838380. VBISynSp132158_0757.

Phylogenomic databases

eggNOGi COG0294.
HOGENOMi HOG000217509.
InParanoidi P73248.
KOi K00796.
OMAi DMFYVAA.
OrthoDBi EOG67T5P5.
PhylomeDBi P73248.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiDHPS_SYNY3
AccessioniPrimary (citable) accession number: P73248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3