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Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88By similarity1
Active sitei188By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
Short name:
MCT
Gene namesi
Name:fabD
Ordered Locus Names:slr2023
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942271 – 293Malonyl CoA-acyl carrier protein transacylaseAdd BLAST293

Structurei

Secondary structure

1293
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Turni15 – 18Combined sources4
Helixi19 – 23Combined sources5
Helixi25 – 38Combined sources14
Helixi42 – 46Combined sources5
Helixi50 – 54Combined sources5
Helixi56 – 76Combined sources21
Beta strandi82 – 87Combined sources6
Helixi90 – 97Combined sources8
Helixi103 – 119Combined sources17
Beta strandi124 – 131Combined sources8
Helixi133 – 140Combined sources8
Beta strandi144 – 153Combined sources10
Beta strandi156 – 161Combined sources6
Helixi163 – 171Combined sources9
Beta strandi173 – 176Combined sources4
Beta strandi178 – 180Combined sources3
Helixi190 – 192Combined sources3
Helixi193 – 204Combined sources12
Beta strandi215 – 217Combined sources3
Beta strandi220 – 224Combined sources5
Helixi227 – 235Combined sources9
Turni236 – 239Combined sources4
Helixi244 – 254Combined sources11
Beta strandi258 – 266Combined sources9
Helixi267 – 273Combined sources7
Beta strandi279 – 284Combined sources6
Helixi287 – 291Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RR5X-ray2.43A1-293[»]
ProteinModelPortaliP73242.
SMRiP73242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Phylogenomic databases

HOGENOMiHOG000036503.
InParanoidiP73242.
KOiK00645.
OMAiFHCALMQ.
PhylomeDBiP73242.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR020801. PKS_acyl_transferase.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SMARTiSM00827. PKS_AT. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.

Sequencei

Sequence statusi: Complete.

P73242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTAWVFPGQ GSQAVGMGVD LLSTAIAKEK YQQAEEILGW SVVEKCQGDE
60 70 80 90 100
ASLALTQNTQ PCLYVIEAIL ADLLRDKGFQ PDYVAGHSLG EYSALYAAGV
110 120 130 140 150
FDFATGLQLV KQRSEVMASA SGGMMAALMK FDQTQLQQAL TDNTEVVLAN
160 170 180 190 200
DNSPEQVVIS GTVAGVEAIL ANVKARRAVP LKVSGAFHSS FMAQPSQSFA
210 220 230 240 250
QTLTACHFND ATVPVLSNVD PSPTQNGDRL KEKLIQQMTG SVRWRETMVN
260 270 280 290
LGEIGATDYW EVGPGKVLTG LCKRTCPDLN LKNIGQLDDL NSL
Length:293
Mass (Da):31,491
Last modified:February 1, 1997 - v1
Checksum:i31E4ABA59ECDB377
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17269.1.
PIRiS75355.

Genome annotation databases

EnsemblBacteriaiBAA17269; BAA17269; BAA17269.
KEGGisyn:slr2023.
PATRICi23838368. VBISynSp132158_0751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17269.1.
PIRiS75355.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RR5X-ray2.43A1-293[»]
ProteinModelPortaliP73242.
SMRiP73242.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17269; BAA17269; BAA17269.
KEGGisyn:slr2023.
PATRICi23838368. VBISynSp132158_0751.

Phylogenomic databases

HOGENOMiHOG000036503.
InParanoidiP73242.
KOiK00645.
OMAiFHCALMQ.
PhylomeDBiP73242.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR020801. PKS_acyl_transferase.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SMARTiSM00827. PKS_AT. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFABD_SYNY3
AccessioniPrimary (citable) accession number: P73242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.