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Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881By similarity
Active sitei188 – 1881By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
Short name:
MCT
Gene namesi
Name:fabD
Ordered Locus Names:slr2023
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Malonyl CoA-acyl carrier protein transacylasePRO_0000194227Add
BLAST

Structurei

Secondary structure

1
293
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75Combined sources
Turni15 – 184Combined sources
Helixi19 – 235Combined sources
Helixi25 – 3814Combined sources
Helixi42 – 465Combined sources
Helixi50 – 545Combined sources
Helixi56 – 7621Combined sources
Beta strandi82 – 876Combined sources
Helixi90 – 978Combined sources
Helixi103 – 11917Combined sources
Beta strandi124 – 1318Combined sources
Helixi133 – 1408Combined sources
Beta strandi144 – 15310Combined sources
Beta strandi156 – 1616Combined sources
Helixi163 – 1719Combined sources
Beta strandi173 – 1764Combined sources
Beta strandi178 – 1803Combined sources
Helixi190 – 1923Combined sources
Helixi193 – 20412Combined sources
Beta strandi215 – 2173Combined sources
Beta strandi220 – 2245Combined sources
Helixi227 – 2359Combined sources
Turni236 – 2394Combined sources
Helixi244 – 25411Combined sources
Beta strandi258 – 2669Combined sources
Helixi267 – 2737Combined sources
Beta strandi279 – 2846Combined sources
Helixi287 – 2915Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RR5X-ray2.43A1-293[»]
ProteinModelPortaliP73242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Phylogenomic databases

HOGENOMiHOG000036503.
InParanoidiP73242.
KOiK00645.
OMAiFHCALMQ.
OrthoDBiEOG6W19KW.
PhylomeDBiP73242.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR020801. PKS_acyl_transferase.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SMARTiSM00827. PKS_AT. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.

Sequencei

Sequence statusi: Complete.

P73242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTAWVFPGQ GSQAVGMGVD LLSTAIAKEK YQQAEEILGW SVVEKCQGDE
60 70 80 90 100
ASLALTQNTQ PCLYVIEAIL ADLLRDKGFQ PDYVAGHSLG EYSALYAAGV
110 120 130 140 150
FDFATGLQLV KQRSEVMASA SGGMMAALMK FDQTQLQQAL TDNTEVVLAN
160 170 180 190 200
DNSPEQVVIS GTVAGVEAIL ANVKARRAVP LKVSGAFHSS FMAQPSQSFA
210 220 230 240 250
QTLTACHFND ATVPVLSNVD PSPTQNGDRL KEKLIQQMTG SVRWRETMVN
260 270 280 290
LGEIGATDYW EVGPGKVLTG LCKRTCPDLN LKNIGQLDDL NSL
Length:293
Mass (Da):31,491
Last modified:February 1, 1997 - v1
Checksum:i31E4ABA59ECDB377
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17269.1.
PIRiS75355.

Genome annotation databases

EnsemblBacteriaiBAA17269; BAA17269; BAA17269.
KEGGisyn:slr2023.
PATRICi23838368. VBISynSp132158_0751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17269.1.
PIRiS75355.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RR5X-ray2.43A1-293[»]
ProteinModelPortaliP73242.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17269; BAA17269; BAA17269.
KEGGisyn:slr2023.
PATRICi23838368. VBISynSp132158_0751.

Phylogenomic databases

HOGENOMiHOG000036503.
InParanoidiP73242.
KOiK00645.
OMAiFHCALMQ.
OrthoDBiEOG6W19KW.
PhylomeDBiP73242.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR020801. PKS_acyl_transferase.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SMARTiSM00827. PKS_AT. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiFABD_SYNY3
AccessioniPrimary (citable) accession number: P73242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.