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Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881By similarity
Active sitei188 – 1881By similarity

GO - Molecular functioni

  1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
Short name:
MCT
Gene namesi
Name:fabD
Ordered Locus Names:slr2023
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Malonyl CoA-acyl carrier protein transacylasePRO_0000194227Add
BLAST

Proteomic databases

PaxDbiP73242.

Interactioni

Protein-protein interaction databases

STRINGi1148.slr2023.

Structurei

3D structure databases

ProteinModelPortaliP73242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000036503.
InParanoidiP73242.
KOiK00645.
OMAiPVVTNVE.
OrthoDBiEOG6W19KW.
PhylomeDBiP73242.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.

Sequencei

Sequence statusi: Complete.

P73242-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTAWVFPGQ GSQAVGMGVD LLSTAIAKEK YQQAEEILGW SVVEKCQGDE
60 70 80 90 100
ASLALTQNTQ PCLYVIEAIL ADLLRDKGFQ PDYVAGHSLG EYSALYAAGV
110 120 130 140 150
FDFATGLQLV KQRSEVMASA SGGMMAALMK FDQTQLQQAL TDNTEVVLAN
160 170 180 190 200
DNSPEQVVIS GTVAGVEAIL ANVKARRAVP LKVSGAFHSS FMAQPSQSFA
210 220 230 240 250
QTLTACHFND ATVPVLSNVD PSPTQNGDRL KEKLIQQMTG SVRWRETMVN
260 270 280 290
LGEIGATDYW EVGPGKVLTG LCKRTCPDLN LKNIGQLDDL NSL
Length:293
Mass (Da):31,491
Last modified:February 1, 1997 - v1
Checksum:i31E4ABA59ECDB377
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17269.1.
PIRiS75355.
RefSeqiNP_440589.1. NC_000911.1.
YP_005650647.1. NC_017277.1.
YP_007450472.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17269; BAA17269; BAA17269.
GeneIDi953892.
KEGGisyn:slr2023.
PATRICi23838368. VBISynSp132158_0751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17269.1.
PIRiS75355.
RefSeqiNP_440589.1. NC_000911.1.
YP_005650647.1. NC_017277.1.
YP_007450472.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP73242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1148.slr2023.

Proteomic databases

PaxDbiP73242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17269; BAA17269; BAA17269.
GeneIDi953892.
KEGGisyn:slr2023.
PATRICi23838368. VBISynSp132158_0751.

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000036503.
InParanoidiP73242.
KOiK00645.
OMAiPVVTNVE.
OrthoDBiEOG6W19KW.
PhylomeDBiP73242.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiFABD_SYNY3
AccessioniPrimary (citable) accession number: P73242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.