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Protein

Probable copper-transporting ATPase PacS

Gene

pacS

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the osmotic adaptation.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.
ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141PROSITE-ProRule annotation
Metal bindingi17 – 171PROSITE-ProRule annotation
Active sitei428 – 42814-aspartylphosphate intermediateCurated
Metal bindingi633 – 6331MagnesiumPROSITE-ProRule annotation
Metal bindingi637 – 6371MagnesiumPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cation-transporting ATPase activity Source: InterPro
  3. copper ion binding Source: UniProtKB

GO - Biological processi

  1. copper ion import Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable copper-transporting ATPase PacS (EC:3.6.3.54)
Gene namesi
Name:pacS
Ordered Locus Names:sll1920
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9494CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence AnalysisAdd
BLAST
Topological domaini116 – 12510ExtracellularSequence Analysis
Transmembranei126 – 14520HelicalSequence AnalysisAdd
BLAST
Topological domaini146 – 1527CytoplasmicSequence Analysis
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Topological domaini174 – 19320ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Topological domaini215 – 342128CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei343 – 36523HelicalSequence AnalysisAdd
BLAST
Topological domaini366 – 3727ExtracellularSequence Analysis
Transmembranei373 – 39018HelicalSequence AnalysisAdd
BLAST
Topological domaini391 – 543153CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei544 – 56421HelicalSequence AnalysisAdd
BLAST
Topological domaini565 – 687123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei688 – 70720HelicalSequence AnalysisAdd
BLAST
Topological domaini708 – 71912CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei720 – 73819HelicalSequence AnalysisAdd
BLAST
Topological domaini739 – 7457ExtracellularSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745Probable copper-transporting ATPase PacSPRO_0000046161Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP73241.

Interactioni

Protein-protein interaction databases

DIPiDIP-35107N.
IntActiP73241. 11 interactions.
MINTiMINT-223932.
STRINGi1148.sll1920.

Structurei

Secondary structure

1
745
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 119Combined sources
Helixi15 – 2612Combined sources
Beta strandi31 – 377Combined sources
Turni38 – 414Combined sources
Beta strandi42 – 476Combined sources
Beta strandi49 – 513Combined sources
Helixi53 – 6210Combined sources
Beta strandi66 – 694Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GCFNMR-A1-73[»]
2XMWX-ray1.80A1-71[»]
4A48X-ray1.40A/B2-70[»]
4A4JX-ray1.25A2-70[»]
ProteinModelPortaliP73241.
SMRiP73241. Positions 1-73.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP73241.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 6966HMAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2217.
HOGENOMiHOG000250397.
InParanoidiP73241.
KOiK17686.
OMAiIALPGMN.
OrthoDBiEOG6742RM.
PhylomeDBiP73241.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTINLQLE GMRCAACASS IERAIAKVPG VQSCQVNFAL EQAVVSYHGE
60 70 80 90 100
TTPQILTDAV ERAGYHARVL KQQVLSSQQT EDRKPVFSAK LVTGLVISAV
110 120 130 140 150
LFFGSLPMML GVNIPHFPHI FHDPWLQWLL ATPVQFWSGA EFYRGAWKSV
160 170 180 190 200
RTRSATMDTL VALGTSAAYF YSVAITLFPQ WLTSQGLAAH VYFEAAAVVI
210 220 230 240 250
TLILLGRSLE QRARRETSAA IRKLMGLQPQ TALVKRGEHW ETVAIAELAI
260 270 280 290 300
NDVVRVRPGE KIPVDGVVVA GNSTVDESLV TGESFPVDKT VGTEVIGATL
310 320 330 340 350
NKSGSLDIQV SKLGQDSVLA QIIQLVQQAQ ASKAPIQHFV DRITHWFVPT
360 370 380 390 400
VIVVAIAAFC IWWLTTGNIT LAVLTLVEVL IIACPCALGL ATPTSVMVGT
410 420 430 440 450
GKGAEYGVLI KEASSLEMAE KLTAIVLDKT GTLTQGKPSV TNFFTLSPTS
460 470 480 490 500
TEESLQLIQW AASVEQYSEH PLAEAVVNYG QSQQVSLLEI DNFQAIAGCG
510 520 530 540 550
VAGQWQGQWI RLGTSNWLTD LGVTGTEHQP WQSQAQQWEK EQKTVIWLAV
560 570 580 590 600
DTEVKALLAI ADAIKPSSPQ VVQALKKLGL SVYMLTGDNQ ATAQAIADTV
610 620 630 640 650
GIRHVLAQVR PGDKAQQVEQ LQQKGNIVAM VGDGINDAPA LAQADVGIAI
660 670 680 690 700
GTGTDVAIAA SDITLIAGDL QGILTAIKLS RATMGNIRQN LFFAFIYNVI
710 720 730 740
GIPVAAGLFY PLFGLLLNPI LAGAAMAFSS VSVVTNALRL KKFCP
Length:745
Mass (Da):79,950
Last modified:January 31, 1997 - v1
Checksum:i40831F66621735FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17268.1.
PIRiS75354.
RefSeqiNP_440588.1. NC_000911.1.
YP_005650646.1. NC_017277.1.
YP_007450471.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17268; BAA17268; BAA17268.
KEGGisyn:sll1920.
PATRICi23838366. VBISynSp132158_0750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17268.1.
PIRiS75354.
RefSeqiNP_440588.1. NC_000911.1.
YP_005650646.1. NC_017277.1.
YP_007450471.1. NC_020286.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GCFNMR-A1-73[»]
2XMWX-ray1.80A1-71[»]
4A48X-ray1.40A/B2-70[»]
4A4JX-ray1.25A2-70[»]
ProteinModelPortaliP73241.
SMRiP73241. Positions 1-73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35107N.
IntActiP73241. 11 interactions.
MINTiMINT-223932.
STRINGi1148.sll1920.

Proteomic databases

PaxDbiP73241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17268; BAA17268; BAA17268.
KEGGisyn:sll1920.
PATRICi23838366. VBISynSp132158_0750.

Phylogenomic databases

eggNOGiCOG2217.
HOGENOMiHOG000250397.
InParanoidiP73241.
KOiK17686.
OMAiIALPGMN.
OrthoDBiEOG6742RM.
PhylomeDBiP73241.

Miscellaneous databases

EvolutionaryTraceiP73241.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiATCS_SYNY3
AccessioniPrimary (citable) accession number: P73241
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: January 31, 1997
Last modified: March 31, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.