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Protein

Probable copper-transporting ATPase PacS

Gene

pacS

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the osmotic adaptation.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.
ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi14PROSITE-ProRule annotation1
Metal bindingi17PROSITE-ProRule annotation1
Active sitei4284-aspartylphosphate intermediateCurated1
Metal bindingi633MagnesiumPROSITE-ProRule annotation1
Metal bindingi637MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • copper ion binding Source: UniProtKB
  • copper-transporting ATPase activity Source: GO_Central

GO - Biological processi

  • copper ion import Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable copper-transporting ATPase PacS (EC:3.6.3.54)
Gene namesi
Name:pacS
Ordered Locus Names:sll1920
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 94CytoplasmicSequence analysisAdd BLAST94
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 125ExtracellularSequence analysis10
Transmembranei126 – 145HelicalSequence analysisAdd BLAST20
Topological domaini146 – 152CytoplasmicSequence analysis7
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 193ExtracellularSequence analysisAdd BLAST20
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 342CytoplasmicSequence analysisAdd BLAST128
Transmembranei343 – 365HelicalSequence analysisAdd BLAST23
Topological domaini366 – 372ExtracellularSequence analysis7
Transmembranei373 – 390HelicalSequence analysisAdd BLAST18
Topological domaini391 – 543CytoplasmicSequence analysisAdd BLAST153
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Topological domaini565 – 687ExtracellularSequence analysisAdd BLAST123
Transmembranei688 – 707HelicalSequence analysisAdd BLAST20
Topological domaini708 – 719CytoplasmicSequence analysisAdd BLAST12
Transmembranei720 – 738HelicalSequence analysisAdd BLAST19
Topological domaini739 – 745ExtracellularSequence analysis7

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461611 – 745Probable copper-transporting ATPase PacSAdd BLAST745

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP73241.

Interactioni

Protein-protein interaction databases

DIPiDIP-35107N.
IntActiP73241. 11 interactors.
MINTiMINT-223932.

Structurei

Secondary structure

1745
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 11Combined sources9
Helixi15 – 26Combined sources12
Beta strandi31 – 37Combined sources7
Turni38 – 41Combined sources4
Beta strandi42 – 47Combined sources6
Beta strandi49 – 51Combined sources3
Helixi53 – 62Combined sources10
Beta strandi66 – 69Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GCFNMR-A1-73[»]
2XMWX-ray1.80A1-71[»]
4A48X-ray1.40A/B2-70[»]
4A4JX-ray1.25A2-70[»]
ProteinModelPortaliP73241.
SMRiP73241.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP73241.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 69HMAPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250397.
InParanoidiP73241.
KOiK17686.
OMAiQAWVQAD.
PhylomeDBiP73241.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTINLQLE GMRCAACASS IERAIAKVPG VQSCQVNFAL EQAVVSYHGE
60 70 80 90 100
TTPQILTDAV ERAGYHARVL KQQVLSSQQT EDRKPVFSAK LVTGLVISAV
110 120 130 140 150
LFFGSLPMML GVNIPHFPHI FHDPWLQWLL ATPVQFWSGA EFYRGAWKSV
160 170 180 190 200
RTRSATMDTL VALGTSAAYF YSVAITLFPQ WLTSQGLAAH VYFEAAAVVI
210 220 230 240 250
TLILLGRSLE QRARRETSAA IRKLMGLQPQ TALVKRGEHW ETVAIAELAI
260 270 280 290 300
NDVVRVRPGE KIPVDGVVVA GNSTVDESLV TGESFPVDKT VGTEVIGATL
310 320 330 340 350
NKSGSLDIQV SKLGQDSVLA QIIQLVQQAQ ASKAPIQHFV DRITHWFVPT
360 370 380 390 400
VIVVAIAAFC IWWLTTGNIT LAVLTLVEVL IIACPCALGL ATPTSVMVGT
410 420 430 440 450
GKGAEYGVLI KEASSLEMAE KLTAIVLDKT GTLTQGKPSV TNFFTLSPTS
460 470 480 490 500
TEESLQLIQW AASVEQYSEH PLAEAVVNYG QSQQVSLLEI DNFQAIAGCG
510 520 530 540 550
VAGQWQGQWI RLGTSNWLTD LGVTGTEHQP WQSQAQQWEK EQKTVIWLAV
560 570 580 590 600
DTEVKALLAI ADAIKPSSPQ VVQALKKLGL SVYMLTGDNQ ATAQAIADTV
610 620 630 640 650
GIRHVLAQVR PGDKAQQVEQ LQQKGNIVAM VGDGINDAPA LAQADVGIAI
660 670 680 690 700
GTGTDVAIAA SDITLIAGDL QGILTAIKLS RATMGNIRQN LFFAFIYNVI
710 720 730 740
GIPVAAGLFY PLFGLLLNPI LAGAAMAFSS VSVVTNALRL KKFCP
Length:745
Mass (Da):79,950
Last modified:February 1, 1997 - v1
Checksum:i40831F66621735FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17268.1.
PIRiS75354.

Genome annotation databases

EnsemblBacteriaiBAA17268; BAA17268; BAA17268.
KEGGisyn:sll1920.
PATRICi23838366. VBISynSp132158_0750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17268.1.
PIRiS75354.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GCFNMR-A1-73[»]
2XMWX-ray1.80A1-71[»]
4A48X-ray1.40A/B2-70[»]
4A4JX-ray1.25A2-70[»]
ProteinModelPortaliP73241.
SMRiP73241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35107N.
IntActiP73241. 11 interactors.
MINTiMINT-223932.

Proteomic databases

PRIDEiP73241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17268; BAA17268; BAA17268.
KEGGisyn:sll1920.
PATRICi23838366. VBISynSp132158_0750.

Phylogenomic databases

HOGENOMiHOG000250397.
InParanoidiP73241.
KOiK17686.
OMAiQAWVQAD.
PhylomeDBiP73241.

Miscellaneous databases

EvolutionaryTraceiP73241.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATCS_SYNY3
AccessioniPrimary (citable) accession number: P73241
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.