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P73241 (ATCS_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable copper-transporting ATPase PacS

EC=3.6.3.54
Gene names
Name:pacS
Ordered Locus Names:sll1920
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length745 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the osmotic adaptation By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]

Contains 1 HMA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 745745Probable copper-transporting ATPase PacS
PRO_0000046161

Regions

Topological domain1 – 9494Cytoplasmic Potential
Transmembrane95 – 11521Helical; Potential
Topological domain116 – 12510Extracellular Potential
Transmembrane126 – 14520Helical; Potential
Topological domain146 – 1527Cytoplasmic Potential
Transmembrane153 – 17321Helical; Potential
Topological domain174 – 19320Extracellular Potential
Transmembrane194 – 21421Helical; Potential
Topological domain215 – 342128Cytoplasmic Potential
Transmembrane343 – 36523Helical; Potential
Topological domain366 – 3727Extracellular Potential
Transmembrane373 – 39018Helical; Potential
Topological domain391 – 543153Cytoplasmic Potential
Transmembrane544 – 56421Helical; Potential
Topological domain565 – 687123Extracellular Potential
Transmembrane688 – 70720Helical; Potential
Topological domain708 – 71912Cytoplasmic Potential
Transmembrane720 – 73819Helical; Potential
Topological domain739 – 7457Extracellular Potential
Domain4 – 6966HMA

Sites

Active site42814-aspartylphosphate intermediate Probable
Metal binding141 Potential
Metal binding171 Potential
Metal binding6331Magnesium By similarity
Metal binding6371Magnesium By similarity

Secondary structure

............... 745
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P73241 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 40831F66621735FB

FASTA74579,950
        10         20         30         40         50         60 
MAQTINLQLE GMRCAACASS IERAIAKVPG VQSCQVNFAL EQAVVSYHGE TTPQILTDAV 

        70         80         90        100        110        120 
ERAGYHARVL KQQVLSSQQT EDRKPVFSAK LVTGLVISAV LFFGSLPMML GVNIPHFPHI 

       130        140        150        160        170        180 
FHDPWLQWLL ATPVQFWSGA EFYRGAWKSV RTRSATMDTL VALGTSAAYF YSVAITLFPQ 

       190        200        210        220        230        240 
WLTSQGLAAH VYFEAAAVVI TLILLGRSLE QRARRETSAA IRKLMGLQPQ TALVKRGEHW 

       250        260        270        280        290        300 
ETVAIAELAI NDVVRVRPGE KIPVDGVVVA GNSTVDESLV TGESFPVDKT VGTEVIGATL 

       310        320        330        340        350        360 
NKSGSLDIQV SKLGQDSVLA QIIQLVQQAQ ASKAPIQHFV DRITHWFVPT VIVVAIAAFC 

       370        380        390        400        410        420 
IWWLTTGNIT LAVLTLVEVL IIACPCALGL ATPTSVMVGT GKGAEYGVLI KEASSLEMAE 

       430        440        450        460        470        480 
KLTAIVLDKT GTLTQGKPSV TNFFTLSPTS TEESLQLIQW AASVEQYSEH PLAEAVVNYG 

       490        500        510        520        530        540 
QSQQVSLLEI DNFQAIAGCG VAGQWQGQWI RLGTSNWLTD LGVTGTEHQP WQSQAQQWEK 

       550        560        570        580        590        600 
EQKTVIWLAV DTEVKALLAI ADAIKPSSPQ VVQALKKLGL SVYMLTGDNQ ATAQAIADTV 

       610        620        630        640        650        660 
GIRHVLAQVR PGDKAQQVEQ LQQKGNIVAM VGDGINDAPA LAQADVGIAI GTGTDVAIAA 

       670        680        690        700        710        720 
SDITLIAGDL QGILTAIKLS RATMGNIRQN LFFAFIYNVI GIPVAAGLFY PLFGLLLNPI 

       730        740 
LAGAAMAFSS VSVVTNALRL KKFCP 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA17268.1.
PIRS75354.
RefSeqNP_440588.1. NC_000911.1.
YP_005650646.1. NC_017277.1.
YP_007450471.1. NC_020286.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2GCFNMR-A1-73[»]
2XMWX-ray1.80A1-71[»]
4A48X-ray1.40A/B2-70[»]
4A4JX-ray1.25A2-70[»]
ProteinModelPortalP73241.
SMRP73241. Positions 1-73.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP73241. 11 interactions.
MINTMINT-223932.
STRING1148.sll1920.

Proteomic databases

PaxDbP73241.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17268; BAA17268; BAA17268.
GeneID953891.
KEGGsyn:sll1920.
syy:SYNGTS_0693.
syz:MYO_16990.
PATRIC23838366. VBISynSp132158_0750.

Phylogenomic databases

eggNOGCOG2217.
HOGENOMHOG000250397.
KOK17686.
OMAMDGVEAN.
OrthoDBEOG6742RM.
PhylomeDBP73241.

Family and domain databases

Gene3D2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR027256. Cation_transp_P-typ_ATPase_IB.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
[Graphical view]
PfamPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SUPFAMSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP73241.

Entry information

Entry nameATCS_SYNY3
AccessionPrimary (citable) accession number: P73241
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references