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P73241

- ATCS_SYNY3

UniProt

P73241 - ATCS_SYNY3

Protein

Probable copper-transporting ATPase PacS

Gene

pacS

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    May play a role in the osmotic adaptation.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.
    ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi14 – 141PROSITE-ProRule annotation
    Metal bindingi17 – 171PROSITE-ProRule annotation
    Active sitei428 – 42814-aspartylphosphate intermediateCurated
    Metal bindingi633 – 6331MagnesiumPROSITE-ProRule annotation
    Metal bindingi637 – 6371MagnesiumPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cation-transporting ATPase activity Source: InterPro
    3. copper ion binding Source: UniProtKB

    GO - Biological processi

    1. copper ion import Source: UniProtKB
    2. copper ion transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Copper transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable copper-transporting ATPase PacS (EC:3.6.3.54)
    Gene namesi
    Name:pacS
    Ordered Locus Names:sll1920
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 745745Probable copper-transporting ATPase PacSPRO_0000046161Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP73241.

    Interactioni

    Protein-protein interaction databases

    IntActiP73241. 11 interactions.
    MINTiMINT-223932.
    STRINGi1148.sll1920.

    Structurei

    Secondary structure

    1
    745
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 119
    Helixi15 – 2612
    Beta strandi31 – 377
    Turni38 – 414
    Beta strandi42 – 476
    Beta strandi49 – 513
    Helixi53 – 6210
    Beta strandi66 – 694

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2GCFNMR-A1-73[»]
    2XMWX-ray1.80A1-71[»]
    4A48X-ray1.40A/B2-70[»]
    4A4JX-ray1.25A2-70[»]
    ProteinModelPortaliP73241.
    SMRiP73241. Positions 1-73.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP73241.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9494CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini116 – 12510ExtracellularSequence Analysis
    Topological domaini146 – 1527CytoplasmicSequence Analysis
    Topological domaini174 – 19320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini215 – 342128CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini366 – 3727ExtracellularSequence Analysis
    Topological domaini391 – 543153CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini565 – 687123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini708 – 71912CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini739 – 7457ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei95 – 11521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei343 – 36523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei373 – 39018HelicalSequence AnalysisAdd
    BLAST
    Transmembranei544 – 56421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei688 – 70720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei720 – 73819HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 6966HMAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2217.
    HOGENOMiHOG000250397.
    KOiK17686.
    OMAiMDGVEAN.
    OrthoDBiEOG6742RM.
    PhylomeDBiP73241.

    Family and domain databases

    Gene3Di2.70.150.10. 1 hit.
    3.40.1110.10. 1 hit.
    3.40.50.1000. 2 hits.
    InterProiIPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR027256. Cation_transp_P-typ_ATPase_IB.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    IPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    [Graphical view]
    PfamiPF00122. E1-E2_ATPase. 1 hit.
    PF00403. HMA. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SUPFAMiSSF55008. SSF55008. 1 hit.
    SSF56784. SSF56784. 2 hits.
    TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    PS01047. HMA_1. 1 hit.
    PS50846. HMA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73241-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQTINLQLE GMRCAACASS IERAIAKVPG VQSCQVNFAL EQAVVSYHGE    50
    TTPQILTDAV ERAGYHARVL KQQVLSSQQT EDRKPVFSAK LVTGLVISAV 100
    LFFGSLPMML GVNIPHFPHI FHDPWLQWLL ATPVQFWSGA EFYRGAWKSV 150
    RTRSATMDTL VALGTSAAYF YSVAITLFPQ WLTSQGLAAH VYFEAAAVVI 200
    TLILLGRSLE QRARRETSAA IRKLMGLQPQ TALVKRGEHW ETVAIAELAI 250
    NDVVRVRPGE KIPVDGVVVA GNSTVDESLV TGESFPVDKT VGTEVIGATL 300
    NKSGSLDIQV SKLGQDSVLA QIIQLVQQAQ ASKAPIQHFV DRITHWFVPT 350
    VIVVAIAAFC IWWLTTGNIT LAVLTLVEVL IIACPCALGL ATPTSVMVGT 400
    GKGAEYGVLI KEASSLEMAE KLTAIVLDKT GTLTQGKPSV TNFFTLSPTS 450
    TEESLQLIQW AASVEQYSEH PLAEAVVNYG QSQQVSLLEI DNFQAIAGCG 500
    VAGQWQGQWI RLGTSNWLTD LGVTGTEHQP WQSQAQQWEK EQKTVIWLAV 550
    DTEVKALLAI ADAIKPSSPQ VVQALKKLGL SVYMLTGDNQ ATAQAIADTV 600
    GIRHVLAQVR PGDKAQQVEQ LQQKGNIVAM VGDGINDAPA LAQADVGIAI 650
    GTGTDVAIAA SDITLIAGDL QGILTAIKLS RATMGNIRQN LFFAFIYNVI 700
    GIPVAAGLFY PLFGLLLNPI LAGAAMAFSS VSVVTNALRL KKFCP 745
    Length:745
    Mass (Da):79,950
    Last modified:February 1, 1997 - v1
    Checksum:i40831F66621735FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17268.1.
    PIRiS75354.
    RefSeqiNP_440588.1. NC_000911.1.
    YP_005650646.1. NC_017277.1.
    YP_007450471.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17268; BAA17268; BAA17268.
    GeneIDi953891.
    KEGGisyn:sll1920.
    syy:SYNGTS_0693.
    syz:MYO_16990.
    PATRICi23838366. VBISynSp132158_0750.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17268.1 .
    PIRi S75354.
    RefSeqi NP_440588.1. NC_000911.1.
    YP_005650646.1. NC_017277.1.
    YP_007450471.1. NC_020286.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2GCF NMR - A 1-73 [» ]
    2XMW X-ray 1.80 A 1-71 [» ]
    4A48 X-ray 1.40 A/B 2-70 [» ]
    4A4J X-ray 1.25 A 2-70 [» ]
    ProteinModelPortali P73241.
    SMRi P73241. Positions 1-73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P73241. 11 interactions.
    MINTi MINT-223932.
    STRINGi 1148.sll1920.

    Proteomic databases

    PaxDbi P73241.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17268 ; BAA17268 ; BAA17268 .
    GeneIDi 953891.
    KEGGi syn:sll1920.
    syy:SYNGTS_0693.
    syz:MYO_16990.
    PATRICi 23838366. VBISynSp132158_0750.

    Phylogenomic databases

    eggNOGi COG2217.
    HOGENOMi HOG000250397.
    KOi K17686.
    OMAi MDGVEAN.
    OrthoDBi EOG6742RM.
    PhylomeDBi P73241.

    Miscellaneous databases

    EvolutionaryTracei P73241.

    Family and domain databases

    Gene3Di 2.70.150.10. 1 hit.
    3.40.1110.10. 1 hit.
    3.40.50.1000. 2 hits.
    InterProi IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR027256. Cation_transp_P-typ_ATPase_IB.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    IPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    [Graphical view ]
    Pfami PF00122. E1-E2_ATPase. 1 hit.
    PF00403. HMA. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SUPFAMi SSF55008. SSF55008. 1 hit.
    SSF56784. SSF56784. 2 hits.
    TIGRFAMsi TIGR01525. ATPase-IB_hvy. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    PS01047. HMA_1. 1 hit.
    PS50846. HMA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiATCS_SYNY3
    AccessioniPrimary (citable) accession number: P73241
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3