ID P73213_SYNY3 Unreviewed; 64 AA. AC P73213; DT 01-FEB-1997, integrated into UniProtKB/TrEMBL. DT 01-FEB-1997, sequence version 1. DT 27-MAR-2024, entry version 153. DE SubName: Full=Ssr2857 protein {ECO:0000313|EMBL:BAA17240.1}; GN OrderedLocusNames=ssr2857 {ECO:0000313|EMBL:BAA17240.1}; OS Synechocystis sp. (strain PCC 6803 / Kazusa). OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae; OC Synechocystis. OX NCBI_TaxID=1111708 {ECO:0000313|EMBL:BAA17240.1, ECO:0000313|Proteomes:UP000001425}; RN [1] {ECO:0000313|EMBL:BAA17240.1, ECO:0000313|Proteomes:UP000001425} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PCC 6803 / Kazusa {ECO:0000313|Proteomes:UP000001425}; RX PubMed=8905231; DOI=10.1093/dnares/3.3.109; RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S., RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.; RT "Sequence analysis of the genome of the unicellular cyanobacterium RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire RT genome and assignment of potential protein-coding regions."; RL DNA Res. 3:109-136(1996). RN [2] {ECO:0007829|PDB:1SB6} RP STRUCTURE BY NMR. RX PubMed=15075318; DOI=10.1074/jbc.M402005200; RA Banci L., Bertini I., Ciofi-Baffoni S., Su X.C., Borrelly G.P., RA Robinson N.J.; RT "Solution structures of a cyanobacterial metallochaperone: insight into an RT atypical copper-binding motif."; RL J. Biol. Chem. 279:27502-27510(2004). RN [3] {ECO:0007829|PDB:2XMJ, ECO:0007829|PDB:2XMK} RP X-RAY CRYSTALLOGRAPHY (1.08 ANGSTROMS) IN COMPLEX WITH COPPER. RX PubMed=20726513; DOI=10.1021/bi101064w; RA Badarau A., Firbank S.J., McCarthy A.A., Banfield M.J., Dennison C.; RT "Visualizing the metal-binding versatility of copper trafficking sites ."; RL Biochemistry 49:7798-7810(2010). RN [4] {ECO:0007829|PDB:4A47} RP X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 2-64 IN COMPLEX WITH ZINC. RX PubMed=24050657; DOI=10.1021/BI400492T; RA Badarau A., Basle A., Firbank S.J., Dennison C.; RT "Investigating the role of zinc and copper binding motifs of trafficking RT sites in the cyanobacterium Synechocystis PCC 6803."; RL Biochemistry 52:6816-6823(2013). RN [5] {ECO:0007829|PDB:4A46} RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 2-64 IN COMPLEX WITH ZN(2+). RX PubMed=23926594; DOI=10.1039/C3CC42709A; RA Badarau A., Basle A., Firbank S.J., Dennison C.; RT "Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate RT domains."; RL Chem. Commun. (Camb.) 49:8000-8002(2013). CC -!- INTERACTION: CC P73213; P73241: pacS; NbExp=3; IntAct=EBI-904975, EBI-904982; CC P73213; P74512: slr1950; NbExp=3; IntAct=EBI-904975, EBI-905009; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BA000022; BAA17240.1; -; Genomic_DNA. DR PIR; S75326; S75326. DR PDB; 1SB6; NMR; -; A=1-64. DR PDB; 2XMJ; X-ray; 1.08 A; A/B=1-64. DR PDB; 2XMK; X-ray; 1.35 A; A/B=1-64. DR PDB; 2XMM; X-ray; 1.65 A; A/B=1-64. DR PDB; 2XMT; X-ray; 1.50 A; A/B=1-64. DR PDB; 2XMU; X-ray; 1.75 A; A/B=1-64. DR PDB; 2XMV; X-ray; 1.80 A; A/B/C/D/E/F=1-64. DR PDB; 4A46; X-ray; 1.85 A; A/B/C/D=2-64. DR PDB; 4A47; X-ray; 1.90 A; A/B/C/D=2-64. DR PDBsum; 1SB6; -. DR PDBsum; 2XMJ; -. DR PDBsum; 2XMK; -. DR PDBsum; 2XMM; -. DR PDBsum; 2XMT; -. DR PDBsum; 2XMU; -. DR PDBsum; 2XMV; -. DR PDBsum; 4A46; -. DR PDBsum; 4A47; -. DR AlphaFoldDB; P73213; -. DR SMR; P73213; -. DR DIP; DIP-35106N; -. DR IntAct; P73213; 2. DR STRING; 1148.gene:10498103; -. DR PaxDb; 1148-1652317; -. DR EnsemblBacteria; BAA17240; BAA17240; BAA17240. DR KEGG; syn:ssr2857; -. DR eggNOG; COG2608; Bacteria. DR InParanoid; P73213; -. DR EvolutionaryTrace; P73213; -. DR Proteomes; UP000001425; Chromosome. DR GO; GO:0005507; F:copper ion binding; IDA:UniProtKB. DR CDD; cd00371; HMA; 1. DR Gene3D; 3.30.70.100; -; 1. DR InterPro; IPR017969; Heavy-metal-associated_CS. DR InterPro; IPR006121; HMA_dom. DR InterPro; IPR036163; HMA_dom_sf. DR Pfam; PF00403; HMA; 1. DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1. DR PROSITE; PS01047; HMA_1; 1. DR PROSITE; PS50846; HMA_2; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:1SB6, ECO:0007829|PDB:2XMJ}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0007829|PDB:2XMJ}; KW Reference proteome {ECO:0000313|Proteomes:UP000001425}; KW Transport {ECO:0000256|ARBA:ARBA00022448}; KW Zinc {ECO:0007829|PDB:4A46, ECO:0007829|PDB:4A47}. FT DOMAIN 1..64 FT /note="HMA" FT /evidence="ECO:0000259|PROSITE:PS50846" FT BINDING 12 FT /ligand="Cu(+)" FT /ligand_id="ChEBI:CHEBI:49552" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:2XMU" FT BINDING 12 FT /ligand="Cu(+)" FT /ligand_id="ChEBI:CHEBI:49552" FT /ligand_label="1" FT /evidence="ECO:0007829|PDB:2XMT, ECO:0007829|PDB:2XMV" FT BINDING 12 FT /ligand="Cu(2+)" FT /ligand_id="ChEBI:CHEBI:29036" FT /evidence="ECO:0007829|PDB:2XMJ, ECO:0007829|PDB:2XMK" FT BINDING 12 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0007829|PDB:4A46, ECO:0007829|PDB:4A47" FT BINDING 15 FT /ligand="Cu(+)" FT /ligand_id="ChEBI:CHEBI:49552" FT /ligand_label="1" FT /evidence="ECO:0007829|PDB:2XMT, ECO:0007829|PDB:2XMV" FT BINDING 15 FT /ligand="Cu(+)" FT /ligand_id="ChEBI:CHEBI:49552" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:2XMU" FT BINDING 15 FT /ligand="Cu(2+)" FT /ligand_id="ChEBI:CHEBI:29036" FT /evidence="ECO:0007829|PDB:2XMJ, ECO:0007829|PDB:2XMK" FT BINDING 15 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0007829|PDB:4A46, ECO:0007829|PDB:4A47" FT BINDING 61 FT /ligand="Cu(+)" FT /ligand_id="ChEBI:CHEBI:49552" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:2XMU" SQ SEQUENCE 64 AA; 6686 MW; 111676DBB03D032E CRC64; MTIQLTVPTI ACEACAEAVT KAVQNEDAQA TVQVDLTSKK VTITSALGEE QLRTAIASAG HEVE //