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P73212 (DFRA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative dihydroflavonol-4-reductase

Short name=DFR
EC=1.1.1.219
Alternative name(s):
Dihydrokaempferol 4-reductase
Gene names
Name:dfrA
Ordered Locus Names:slr1706
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular metabolic process

Inferred from electronic annotation. Source: InterPro

flavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

dihydrokaempferol 4-reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Putative dihydroflavonol-4-reductase
PRO_0000215573

Sequences

Sequence LengthMass (Da)Tools
P73212 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 0008B4CC2EF971CA

FASTA34337,864
        10         20         30         40         50         60 
MEVNHWIAMA DCFFVTGGTG FVGANLVRHL LEQGYQVRAL VRASSRPDNL QNLPIDWVVG 

        70         80         90        100        110        120 
DLNDGDLHQQ MQGCQGLFHV AAHYSLWQKD REALYRSNVL GTRNILACAQ KAGIERTVYT 

       130        140        150        160        170        180 
SSVAAIGVKG DGQRADESYQ SPVEKLIGAY KQSKYWAEQE ALTAAQQGQD IVIVNPSTPI 

       190        200        210        220        230        240 
GPWDIKPTPT GEIILRFLRR QMPAYVNTGL NLIDVRDVAA GHLLAWQRGK TALTRGDRYI 

       250        260        270        280        290        300 
LGHENISLQG ILAHLSTITG LPAPKNTVPL WLPLTFAWVE EKVLAPLGRS PSVPMDGVKM 

       310        320        330        340 
SAQEMYYDAS KAVQELGLPQ SSIKQALADA VHWFQNHGYV KTQ 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA17239.1.
PIRS75325.
RefSeqNP_440559.1. NC_000911.1.
YP_007450442.1. NC_020286.1.

3D structure databases

ProteinModelPortalP73212.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP73212. 1 interaction.
STRING1148.slr1706.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17239; BAA17239; BAA17239.
GeneID953860.
KEGGsyn:slr1706.
syz:MYO_16700.
PATRIC23838304. VBISynSp132158_0719.

Phylogenomic databases

eggNOGCOG0451.
HOGENOMHOG000168005.
KOK00091.
OMAMVGHYKK.
OrthoDBEOG6RJV2Z.
PhylomeDBP73212.

Enzyme and pathway databases

BioCycSSP1148:GJOT-672-MONOMER.
UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001509. Epimerase_deHydtase.
IPR017829. Hopanoid-assoc_sugar_epimerase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsTIGR03466. HpnA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDFRA_SYNY3
AccessionPrimary (citable) accession number: P73212
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways