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Protein

Acetate kinase

Gene

ackA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Active sitei157Proton donor/acceptorUniRule annotation1
Sitei188Transition state stabilizerUniRule annotation1
Sitei249Transition state stabilizerUniRule annotation1
Metal bindingi392MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi216 – 220ATPUniRule annotation5
Nucleotide bindingi291 – 293ATPUniRule annotation3
Nucleotide bindingi339 – 343ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:sll1299
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001076301 – 413Acetate kinaseAdd BLAST413

Proteomic databases

PaxDbiP73162.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiP73162. 1 interactor.
STRINGi1148.SYNGTS_0613.

Structurei

3D structure databases

ProteinModelPortaliP73162.
SMRiP73162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288398.
InParanoidiP73162.
KOiK00925.
OMAiWKALTGT.
PhylomeDBiP73162.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P73162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLILNAGS SSQKSCLYEL TGDRLPETIP EPLWEAFIDW TVLANQGRLT
60 70 80 90 100
VETAGQKQVI ILETGDRQQG IARMLDTLVT GDDAVLKSLA EIDLVGHRVV
110 120 130 140 150
HGGTDHAEAT LITPEVQQAI ADLIPLAPAH NPAHLEGIEA ISALLVLGEV
160 170 180 190 200
PQIAVFDTAF HRTIPTPAAE YPIPQAWTNL GIRRYGFHGT SHKYCAQKTA
210 220 230 240 250
EILGKPLADL KLITCHIGNG ASLTAIKNGV SIDTTMGFTP LEGLMMGARS
260 270 280 290 300
GSIDPAILLF LQETQGLTPA EINTTLNKKS GLLGVSGLSA DLRTILQAKA
310 320 330 340 350
EGNEQAQLAY VMYIHRFRSC LGQMIASLEG LDTLVFTAGV GENAATVRAD
360 370 380 390 400
VCQAFEFLGL KLDPELNNRS PRDTVISHSD SLVTVLIVHT EEDWAIAQDC
410
WHWWHSQGQR KQS
Length:413
Mass (Da):44,761
Last modified:February 1, 1997 - v1
Checksum:i1B7BDA132FB17ED5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17188.1.
PIRiS75274.

Genome annotation databases

EnsemblBacteriaiBAA17188; BAA17188; BAA17188.
KEGGisyn:sll1299.

Similar proteinsi

Entry informationi

Entry nameiACKA_SYNY3
AccessioniPrimary (citable) accession number: P73162
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 31, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome