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P73161

- TRMB_SYNY3

UniProt

P73161 - TRMB_SYNY3

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401S-adenosyl-L-methionineUniRule annotation
Binding sitei65 – 651S-adenosyl-L-methionineUniRule annotation
Binding sitei92 – 921S-adenosyl-L-methionineUniRule annotation
Active sitei117 – 1171By similarity
Binding sitei117 – 1171S-adenosyl-L-methionineUniRule annotation
Binding sitei121 – 1211SubstrateUniRule annotation
Binding sitei153 – 1531SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:sll1300
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211tRNA (guanine-N(7)-)-methyltransferasePRO_0000171412Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1148.sll1300.

Structurei

3D structure databases

ProteinModelPortaliP73161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1286Interaction with RNAUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000237936.
InParanoidiP73161.
KOiK03439.
OMAiVIQPEFI.
PhylomeDBiP73161.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73161-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARVRIRQHV NPLSEKYRQV LACPDWATVY DDVQRPLHLD IGCARGRFPL
60 70 80 90 100
KMAQQHPDWN FLGVEIRQPL VLEANETGDR LGLKNLHYLF GNINVEPEKF
110 120 130 140 150
FSAFPPTLQR VSIQFPDPWF KQRHNKRRVA QPELVTAIAN ALPPGGEVLL
160 170 180 190 200
QSDVEPVAQD MRDRFAENDN FVFTHDTPWL AENPLGVPTE REIACFNLQR
210
PVYRCLLQRT P
Length:211
Mass (Da):24,416
Last modified:June 1, 2001 - v2
Checksum:i71A13BD64B1FC898
GO

Sequence cautioni

The sequence BAA17187.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17187.1. Different initiation.
PIRiS75273.
RefSeqiYP_007450391.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17187; BAA17187; BAA17187.
KEGGisyz:MYO_16190.
PATRICi23838196. VBISynSp132158_0665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17187.1 . Different initiation.
PIRi S75273.
RefSeqi YP_007450391.1. NC_020286.1.

3D structure databases

ProteinModelPortali P73161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.sll1300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17187 ; BAA17187 ; BAA17187 .
KEGGi syz:MYO_16190.
PATRICi 23838196. VBISynSp132158_0665.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000237936.
InParanoidi P73161.
KOi K03439.
OMAi VIQPEFI.
PhylomeDBi P73161.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiTRMB_SYNY3
AccessioniPrimary (citable) accession number: P73161
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3