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Protein

Probable signal peptidase I-2

Gene

lepB2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52By similarity1
Active sitei100By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable signal peptidase I-2 (EC:3.4.21.89)
Short name:
SPase I-2
Alternative name(s):
Leader peptidase I-2
Gene namesi
Name:lepB2
Ordered Locus Names:slr1377
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 43HelicalSequence analysisAdd BLAST17
Topological domaini44 – 218PeriplasmicSequence analysisAdd BLAST175

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095361 – 218Probable signal peptidase I-2Add BLAST218

Proteomic databases

PRIDEiP73157.

Structurei

3D structure databases

ProteinModelPortaliP73157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000003673.
InParanoidiP73157.
KOiK03100.
OMAiTFIVQAY.
PhylomeDBiP73157.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENIVRETS KKKESPPENT WLELGKTMVT AVILAIGIRT FVAEARYIPS
60 70 80 90 100
SSMEPTLQIN DRLIIEKISY RLRDPERGEI VVFNPTDALK AKNFHDAFIK
110 120 130 140 150
RIIGLPGDEV RVSQGNVYVN GKMLDENYIA APPAYEYGPV KVPDDQYLVL
160 170 180 190 200
GDNRNNSYDS HYWGFVPREK LLGRAFVRFW PVPRVGLLTD DAEREAVEIS
210
PQAWESPAIS PQTVPESR
Length:218
Mass (Da):24,733
Last modified:February 1, 1997 - v1
Checksum:iF081C2AE157B20DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17183.1.
PIRiS75269.

Genome annotation databases

EnsemblBacteriaiBAA17183; BAA17183; BAA17183.
KEGGisyn:slr1377.
PATRICi23838188. VBISynSp132158_0661.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17183.1.
PIRiS75269.

3D structure databases

ProteinModelPortaliP73157.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS26.008.

Proteomic databases

PRIDEiP73157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17183; BAA17183; BAA17183.
KEGGisyn:slr1377.
PATRICi23838188. VBISynSp132158_0661.

Phylogenomic databases

HOGENOMiHOG000003673.
InParanoidiP73157.
KOiK03100.
OMAiTFIVQAY.
PhylomeDBiP73157.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEP2_SYNY3
AccessioniPrimary (citable) accession number: P73157
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.