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P73138

- FRMA_SYNY3

UniProt

P73138 - FRMA_SYNY3

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Protein

S-(hydroxymethyl)glutathione dehydrogenase

Gene

frmA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.
An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi40 – 401Zinc 1; catalyticBy similarity
Metal bindingi62 – 621Zinc 1; catalyticBy similarity
Metal bindingi92 – 921Zinc 2By similarity
Metal bindingi95 – 951Zinc 2By similarity
Metal bindingi98 – 981Zinc 2By similarity
Metal bindingi106 – 1061Zinc 2By similarity
Metal bindingi169 – 1691Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. alcohol dehydrogenase (NAD) activity Source: UniProtKB-EC
  2. S-(hydroxymethyl)glutathione dehydrogenase activity Source: UniProtKB-EC
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. ethanol oxidation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
Alternative name(s):
Alcohol dehydrogenase class-3 (EC:1.1.1.1)
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
Gene namesi
Name:frmA
Ordered Locus Names:sll0990
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369S-(hydroxymethyl)glutathione dehydrogenasePRO_0000160778Add
BLAST

Proteomic databases

PaxDbiP73138.

Interactioni

Protein-protein interaction databases

STRINGi1148.sll0990.

Structurei

3D structure databases

ProteinModelPortaliP73138.
SMRiP73138. Positions 1-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1062.
InParanoidiP73138.
KOiK00121.
OMAiAWKSGAP.
OrthoDBiEOG6K9QDH.
PhylomeDBiP73138.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73138-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSRAAVAFE VGKPLQIVEI DVAPPQQGEV LVKITHTGVC HTDAFTLSGD
60 70 80 90 100
DPEGLFPVVL GHEGAGIVVE VGEGVTSVQL GDHVIPLYTA ECGKCLFCRS
110 120 130 140 150
GKTNLCVAVR ATQGKGVMPD GTSRFSYNGQ SLYHYMGCST FSEYTVVAEV
160 170 180 190 200
SLAKINPEAN HEHVCLLGCG VTTGIGAVHN TAKVQPGDSV AVFGLGGIGL
210 220 230 240 250
AVVQGARQAK AGRIIAIDTN PAKFELAKQM GATDCINPKD HDQPIQQVIV
260 270 280 290 300
EMTGWGVDHS FECIGNVEVM RSALECAHRG WGQSVIIGVA GAGQEISTRP
310 320 330 340 350
FQLVTGRKWM GTAFGGVKGR SQLPGMVEQS MRGEIQLAPF VTHTMELKDI
360
NQAFDLMHDG KSIRSVIHY
Length:369
Mass (Da):39,211
Last modified:February 1, 1997 - v1
Checksum:iC8A337424F2F1680
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17164.1.
PIRiS75250.
RefSeqiNP_440484.1. NC_000911.1.
YP_005650542.1. NC_017277.1.
YP_007450368.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17164; BAA17164; BAA17164.
GeneIDi953785.
KEGGisyn:sll0990.
PATRICi23838146. VBISynSp132158_0641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17164.1 .
PIRi S75250.
RefSeqi NP_440484.1. NC_000911.1.
YP_005650542.1. NC_017277.1.
YP_007450368.1. NC_020286.1.

3D structure databases

ProteinModelPortali P73138.
SMRi P73138. Positions 1-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.sll0990.

Proteomic databases

PaxDbi P73138.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17164 ; BAA17164 ; BAA17164 .
GeneIDi 953785.
KEGGi syn:sll0990.
PATRICi 23838146. VBISynSp132158_0641.

Phylogenomic databases

eggNOGi COG1062.
InParanoidi P73138.
KOi K00121.
OMAi AWKSGAP.
OrthoDBi EOG6K9QDH.
PhylomeDBi P73138.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 2 hits.
TIGRFAMsi TIGR02818. adh_III_F_hyde. 1 hit.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiFRMA_SYNY3
AccessioniPrimary (citable) accession number: P73138
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3