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P73138

- FRMA_SYNY3

UniProt

P73138 - FRMA_SYNY3

Protein

S-(hydroxymethyl)glutathione dehydrogenase

Gene

frmA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.
    An alcohol + NAD+ = an aldehyde or ketone + NADH.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi40 – 401Zinc 1; catalyticBy similarity
    Metal bindingi62 – 621Zinc 1; catalyticBy similarity
    Metal bindingi92 – 921Zinc 2By similarity
    Metal bindingi95 – 951Zinc 2By similarity
    Metal bindingi98 – 981Zinc 2By similarity
    Metal bindingi106 – 1061Zinc 2By similarity
    Metal bindingi169 – 1691Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. alcohol dehydrogenase (NAD) activity Source: UniProtKB-EC
    2. S-(hydroxymethyl)glutathione dehydrogenase activity Source: UniProtKB-EC
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. ethanol oxidation Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
    Alternative name(s):
    Alcohol dehydrogenase class-3 (EC:1.1.1.1)
    Alcohol dehydrogenase class-III
    Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
    Short name:
    FALDH
    Short name:
    FDH
    Short name:
    GSH-FDH
    Gene namesi
    Name:frmA
    Ordered Locus Names:sll0990
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369S-(hydroxymethyl)glutathione dehydrogenasePRO_0000160778Add
    BLAST

    Proteomic databases

    PaxDbiP73138.

    Interactioni

    Protein-protein interaction databases

    STRINGi1148.sll0990.

    Structurei

    3D structure databases

    ProteinModelPortaliP73138.
    SMRiP73138. Positions 1-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1062.
    KOiK00121.
    OMAiAWKSGAP.
    OrthoDBiEOG6K9QDH.
    PhylomeDBiP73138.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR014183. ADH_3.
    IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 2 hits.
    TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
    PROSITEiPS00059. ADH_ZINC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73138-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSRAAVAFE VGKPLQIVEI DVAPPQQGEV LVKITHTGVC HTDAFTLSGD    50
    DPEGLFPVVL GHEGAGIVVE VGEGVTSVQL GDHVIPLYTA ECGKCLFCRS 100
    GKTNLCVAVR ATQGKGVMPD GTSRFSYNGQ SLYHYMGCST FSEYTVVAEV 150
    SLAKINPEAN HEHVCLLGCG VTTGIGAVHN TAKVQPGDSV AVFGLGGIGL 200
    AVVQGARQAK AGRIIAIDTN PAKFELAKQM GATDCINPKD HDQPIQQVIV 250
    EMTGWGVDHS FECIGNVEVM RSALECAHRG WGQSVIIGVA GAGQEISTRP 300
    FQLVTGRKWM GTAFGGVKGR SQLPGMVEQS MRGEIQLAPF VTHTMELKDI 350
    NQAFDLMHDG KSIRSVIHY 369
    Length:369
    Mass (Da):39,211
    Last modified:February 1, 1997 - v1
    Checksum:iC8A337424F2F1680
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17164.1.
    PIRiS75250.
    RefSeqiNP_440484.1. NC_000911.1.
    YP_005650542.1. NC_017277.1.
    YP_007450368.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17164; BAA17164; BAA17164.
    GeneIDi953785.
    KEGGisyn:sll0990.
    syy:SYNGTS_0589.
    syz:MYO_15950.
    PATRICi23838146. VBISynSp132158_0641.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17164.1 .
    PIRi S75250.
    RefSeqi NP_440484.1. NC_000911.1.
    YP_005650542.1. NC_017277.1.
    YP_007450368.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73138.
    SMRi P73138. Positions 1-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.sll0990.

    Proteomic databases

    PaxDbi P73138.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17164 ; BAA17164 ; BAA17164 .
    GeneIDi 953785.
    KEGGi syn:sll0990.
    syy:SYNGTS_0589.
    syz:MYO_15950.
    PATRICi 23838146. VBISynSp132158_0641.

    Phylogenomic databases

    eggNOGi COG1062.
    KOi K00121.
    OMAi AWKSGAP.
    OrthoDBi EOG6K9QDH.
    PhylomeDBi P73138.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR014183. ADH_3.
    IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 2 hits.
    TIGRFAMsi TIGR02818. adh_III_F_hyde. 1 hit.
    PROSITEi PS00059. ADH_ZINC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiFRMA_SYNY3
    AccessioniPrimary (citable) accession number: P73138
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3