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P73133

- ARGD_SYNY3

UniProt

P73133 - ARGD_SYNY3

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Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei160 – 1601Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
Binding sitei163 – 1631N2-acetyl-L-ornithineUniRule annotation
Binding sitei307 – 3071N2-acetyl-L-ornithineUniRule annotation
Binding sitei308 – 3081Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Ordered Locus Names:slr1022
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Acetylornithine aminotransferasePRO_0000112804Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei280 – 2801N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PaxDbiP73133.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiP73133. 2 interactions.
STRINGi1148.slr1022.

Structurei

3D structure databases

ProteinModelPortaliP73133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 2544Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG4992.
HOGENOMiHOG000020206.
InParanoidiP73133.
KOiK00818.
OMAiFQHEGIV.
OrthoDBiEOG6QVRHN.
PhylomeDBiP73133.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00707. argD. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73133 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTYSPVVESV EAQAFAVTDL SPAAEFKTAD FDTYVMNTYG RFPIAIARGQ
60 70 80 90 100
GSTLWDTEGK SYLDFVAGIA TCTLGHAHPA LVRAVSDQIQ KLHHVSNLYY
110 120 130 140 150
IPEQGELAKW IVEHSCADRV FFCNSGAEAN EAAIKLVRKY AHTVLDFLEQ
160 170 180 190 200
PVILTAKASF HGRTLATITA TGQPKYQQYF DPLVPGFDYV PYNDIRSLEN
210 220 230 240 250
KVADLDEGNS RVAAIFLEPL QGEGGVRPGD LAYFKRVREI CDQNDILLVF
260 270 280 290 300
DEVQVGVGRT GKLWGYEHLG VEPDIFTSAK GLAGGVPIGA MMCKKFCDVF
310 320 330 340 350
EPGNHASTFG GNPLACAAGL AVLKTIEGDR LLDNVQARGE QLRSGLAEIK
360 370 380 390 400
NQYPTLFTEV RGWGLINGLE ISAESSLTSV EIVKAAMEQG LLLAPAGPKV
410 420
LRFVPPLVVT EAEIAQAVEI LRQAIATLV
Length:429
Mass (Da):46,567
Last modified:February 1, 1997 - v1
Checksum:i99FAFA3ABE4AE530
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17159.1.
PIRiS75245.
RefSeqiNP_440479.1. NC_000911.1.
YP_005650537.1. NC_017277.1.
YP_007450363.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17159; BAA17159; BAA17159.
GeneIDi953780.
KEGGisyn:slr1022.
syy:SYNGTS_0584.
syz:MYO_15900.
PATRICi23838136. VBISynSp132158_0636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17159.1 .
PIRi S75245.
RefSeqi NP_440479.1. NC_000911.1.
YP_005650537.1. NC_017277.1.
YP_007450363.1. NC_020286.1.

3D structure databases

ProteinModelPortali P73133.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P73133. 2 interactions.
STRINGi 1148.slr1022.

Proteomic databases

PaxDbi P73133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17159 ; BAA17159 ; BAA17159 .
GeneIDi 953780.
KEGGi syn:slr1022.
syy:SYNGTS_0584.
syz:MYO_15900.
PATRICi 23838136. VBISynSp132158_0636.

Phylogenomic databases

eggNOGi COG4992.
HOGENOMi HOG000020206.
InParanoidi P73133.
KOi K00818.
OMAi FQHEGIV.
OrthoDBi EOG6QVRHN.
PhylomeDBi P73133.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00109 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01107. ArgD_aminotrans_3.
InterProi IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00707. argD. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiARGD_SYNY3
AccessioniPrimary (citable) accession number: P73133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3