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P73133 (ARGD_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetylornithine aminotransferase

Short name=ACOAT
EC=2.6.1.11
Gene names
Name:argD
Ordered Locus Names:slr1022
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. HAMAP-Rule MF_01107

Cofactor

Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP-Rule MF_01107

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4. HAMAP-Rule MF_01107

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01107

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01107.

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandPyridoxal phosphate
   Molecular functionAminotransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionN2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Acetylornithine aminotransferase HAMAP-Rule MF_01107
PRO_0000112804

Regions

Region251 – 2544Pyridoxal phosphate binding By similarity

Sites

Binding site1601Pyridoxal phosphate; via carbonyl oxygen By similarity
Binding site1631N2-acetyl-L-ornithine By similarity
Binding site3071N2-acetyl-L-ornithine By similarity
Binding site3081Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue2801N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P73133 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 99FAFA3ABE4AE530

FASTA42946,567
        10         20         30         40         50         60 
MTYSPVVESV EAQAFAVTDL SPAAEFKTAD FDTYVMNTYG RFPIAIARGQ GSTLWDTEGK 

        70         80         90        100        110        120 
SYLDFVAGIA TCTLGHAHPA LVRAVSDQIQ KLHHVSNLYY IPEQGELAKW IVEHSCADRV 

       130        140        150        160        170        180 
FFCNSGAEAN EAAIKLVRKY AHTVLDFLEQ PVILTAKASF HGRTLATITA TGQPKYQQYF 

       190        200        210        220        230        240 
DPLVPGFDYV PYNDIRSLEN KVADLDEGNS RVAAIFLEPL QGEGGVRPGD LAYFKRVREI 

       250        260        270        280        290        300 
CDQNDILLVF DEVQVGVGRT GKLWGYEHLG VEPDIFTSAK GLAGGVPIGA MMCKKFCDVF 

       310        320        330        340        350        360 
EPGNHASTFG GNPLACAAGL AVLKTIEGDR LLDNVQARGE QLRSGLAEIK NQYPTLFTEV 

       370        380        390        400        410        420 
RGWGLINGLE ISAESSLTSV EIVKAAMEQG LLLAPAGPKV LRFVPPLVVT EAEIAQAVEI 


LRQAIATLV 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA17159.1.
PIRS75245.
RefSeqNP_440479.1. NC_000911.1.
YP_005650537.1. NC_017277.1.
YP_007450363.1. NC_020286.1.

3D structure databases

ProteinModelPortalP73133.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP73133. 2 interactions.
STRING1148.slr1022.

Proteomic databases

PaxDbP73133.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17159; BAA17159; BAA17159.
GeneID12256228.
14616012.
953780.
KEGGsyn:slr1022.
syy:SYNGTS_0584.
syz:MYO_15900.
PATRIC23838136. VBISynSp132158_0636.

Phylogenomic databases

eggNOGCOG4992.
HOGENOMHOG000020206.
KOK00818.
OMAINEFDFC.
OrthoDBEOG6QVRHN.
PhylomeDBP73133.
ProtClustDBPRK02627.

Enzyme and pathway databases

UniPathwayUPA00068; UER00109.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01107. ArgD_aminotrans_3.
InterProIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR004636. Trfase_AcOrn/SuccOrn_fam.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR00707. argD. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGD_SYNY3
AccessionPrimary (citable) accession number: P73133
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways