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Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

Catalytic activityi

N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationNote: Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei160Pyridoxal phosphate; via carbonyl oxygenUniRule annotation1
Binding sitei163N2-acetyl-L-ornithineUniRule annotation1
Binding sitei307N2-acetyl-L-ornithineUniRule annotation1
Binding sitei308Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00068; UER00109

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Ordered Locus Names:slr1022
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001128041 – 429Acetylornithine aminotransferaseAdd BLAST429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei280N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiP73133
PRIDEiP73133

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

IntActiP73133, 2 interactors
STRINGi1148.SYNGTS_0584

Structurei

3D structure databases

ProteinModelPortaliP73133
SMRiP73133
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 127Pyridoxal phosphate bindingUniRule annotation2
Regioni251 – 254Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000020206
InParanoidiP73133
KOiK00821
OMAiGIATCTL
PhylomeDBiP73133

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01107 ArgD_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004636 AcOrn/SuccOrn_fam
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00707 argD, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

P73133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYSPVVESV EAQAFAVTDL SPAAEFKTAD FDTYVMNTYG RFPIAIARGQ
60 70 80 90 100
GSTLWDTEGK SYLDFVAGIA TCTLGHAHPA LVRAVSDQIQ KLHHVSNLYY
110 120 130 140 150
IPEQGELAKW IVEHSCADRV FFCNSGAEAN EAAIKLVRKY AHTVLDFLEQ
160 170 180 190 200
PVILTAKASF HGRTLATITA TGQPKYQQYF DPLVPGFDYV PYNDIRSLEN
210 220 230 240 250
KVADLDEGNS RVAAIFLEPL QGEGGVRPGD LAYFKRVREI CDQNDILLVF
260 270 280 290 300
DEVQVGVGRT GKLWGYEHLG VEPDIFTSAK GLAGGVPIGA MMCKKFCDVF
310 320 330 340 350
EPGNHASTFG GNPLACAAGL AVLKTIEGDR LLDNVQARGE QLRSGLAEIK
360 370 380 390 400
NQYPTLFTEV RGWGLINGLE ISAESSLTSV EIVKAAMEQG LLLAPAGPKV
410 420
LRFVPPLVVT EAEIAQAVEI LRQAIATLV
Length:429
Mass (Da):46,567
Last modified:February 1, 1997 - v1
Checksum:i99FAFA3ABE4AE530
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA17159.1
PIRiS75245

Genome annotation databases

EnsemblBacteriaiBAA17159; BAA17159; BAA17159
KEGGisyn:slr1022

Similar proteinsi

Entry informationi

Entry nameiARGD_SYNY3
AccessioniPrimary (citable) accession number: P73133
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

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