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P73133

- ARGD_SYNY3

UniProt

P73133 - ARGD_SYNY3

Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 pyridoxal phosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei160 – 1601Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
    Binding sitei163 – 1631N2-acetyl-L-ornithineUniRule annotation
    Binding sitei307 – 3071N2-acetyl-L-ornithineUniRule annotation
    Binding sitei308 – 3081Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00068; UER00109.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
    Short name:
    ACOATUniRule annotation
    Gene namesi
    Name:argDUniRule annotation
    Ordered Locus Names:slr1022
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Acetylornithine aminotransferasePRO_0000112804Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei280 – 2801N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PaxDbiP73133.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    IntActiP73133. 2 interactions.
    STRINGi1148.slr1022.

    Structurei

    3D structure databases

    ProteinModelPortaliP73133.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni251 – 2544Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4992.
    HOGENOMiHOG000020206.
    KOiK00818.
    OMAiFQHEGIV.
    OrthoDBiEOG6QVRHN.
    PhylomeDBiP73133.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01107. ArgD_aminotrans_3.
    InterProiIPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00707. argD. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73133-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTYSPVVESV EAQAFAVTDL SPAAEFKTAD FDTYVMNTYG RFPIAIARGQ    50
    GSTLWDTEGK SYLDFVAGIA TCTLGHAHPA LVRAVSDQIQ KLHHVSNLYY 100
    IPEQGELAKW IVEHSCADRV FFCNSGAEAN EAAIKLVRKY AHTVLDFLEQ 150
    PVILTAKASF HGRTLATITA TGQPKYQQYF DPLVPGFDYV PYNDIRSLEN 200
    KVADLDEGNS RVAAIFLEPL QGEGGVRPGD LAYFKRVREI CDQNDILLVF 250
    DEVQVGVGRT GKLWGYEHLG VEPDIFTSAK GLAGGVPIGA MMCKKFCDVF 300
    EPGNHASTFG GNPLACAAGL AVLKTIEGDR LLDNVQARGE QLRSGLAEIK 350
    NQYPTLFTEV RGWGLINGLE ISAESSLTSV EIVKAAMEQG LLLAPAGPKV 400
    LRFVPPLVVT EAEIAQAVEI LRQAIATLV 429
    Length:429
    Mass (Da):46,567
    Last modified:February 1, 1997 - v1
    Checksum:i99FAFA3ABE4AE530
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17159.1.
    PIRiS75245.
    RefSeqiNP_440479.1. NC_000911.1.
    YP_005650537.1. NC_017277.1.
    YP_007450363.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17159; BAA17159; BAA17159.
    GeneIDi953780.
    KEGGisyn:slr1022.
    syy:SYNGTS_0584.
    syz:MYO_15900.
    PATRICi23838136. VBISynSp132158_0636.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17159.1 .
    PIRi S75245.
    RefSeqi NP_440479.1. NC_000911.1.
    YP_005650537.1. NC_017277.1.
    YP_007450363.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73133.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P73133. 2 interactions.
    STRINGi 1148.slr1022.

    Proteomic databases

    PaxDbi P73133.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17159 ; BAA17159 ; BAA17159 .
    GeneIDi 953780.
    KEGGi syn:slr1022.
    syy:SYNGTS_0584.
    syz:MYO_15900.
    PATRICi 23838136. VBISynSp132158_0636.

    Phylogenomic databases

    eggNOGi COG4992.
    HOGENOMi HOG000020206.
    KOi K00818.
    OMAi FQHEGIV.
    OrthoDBi EOG6QVRHN.
    PhylomeDBi P73133.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00109 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01107. ArgD_aminotrans_3.
    InterProi IPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00707. argD. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiARGD_SYNY3
    AccessioniPrimary (citable) accession number: P73133
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3