Reviewed, UniProtKB/Swiss-Prot P73058 (HISX1_SYNY3)

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase 1
      Short name=HDH 1
    EC=1.1.1.23

Gene names

Name:	hisD1
Synonyms:	hisD
Ordered Locus Names:	slr1848

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Sequence similarities	Belongs to the histidinol dehydrogenase family.
Caution	The conserved zinc-binding site Asp residue in position 364 is replaced by a Thr.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Histidinol dehydrogenase 1		PRO_0000135865
Sites
	Active site	330	1	Proton acceptor By similarity
	Active site	331	1	Proton acceptor By similarity
	Metal binding	260	1	Zinc By similarity
	Metal binding	263	1	Zinc By similarity
	Metal binding	423	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	P73058-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 76F07AC33439B1E1	FASTA	434	46,534
	10 20 30 40 50 60 MTRILKLSHL TPQQLNQLKR RSEQNIDQAL AIAKEVIEQV KMEGDAGVLH YSRQFDFAGA 70 80 90 100 110 120 TAENLRVSEA EFAEAEKLVD PELRRAVEHA FRNIEKVHAG QMPPPMHLAE IEPGVFAGEK 130 140 150 160 170 180 ITPLPTVGLY VPRGKGAFPS MMLMLAVPAR VAGVKKIVVC TPPDKEGKVE PVSLVTARMA 190 200 210 220 230 240 GVDEVYKLGG VQALAAIAYG TKTVSKVDKL IGPCSIYGAA AKRLLSGIVD VGLPAGPSES 250 260 270 280 290 300 IVLADETTDP KLAALDLLIE AEHGSDSAAL LVTHSASLAE KALGYLGEYL EKLPPWRKKF 310 320 330 340 350 360 CEDGLGSYGG ILLTDSLQAS LDFINDYAPE HLQVLTADPL KLVGKIDNAG EILLGNYTPS 370 380 390 400 410 420 SAATYAIGVN AVLPTGGFAR SYSAVSVFDF LKRSTLAYLT EEGFAGVKET VTTLADYEDF 430 PAHALAIRER ENLL

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA17080.1.
PIR	S75166.
RefSeq	NP_440400.1.
3D structure databases
HSSP	HSSP built from PDB template 1K75 based on UniProtKB P06988.
ModBase	Search...
Protein-protein interaction databases
IntAct	P73058.
Genome annotation databases
GeneID	953700.
GenomeReviews	Gene locus slr1848 in contig BA000022_GR.
KEGG	syn:slr1848.
NMPDR	fig|1148.1.peg.501.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P73058.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1848-MON.
Family and domain databases
HAMAP	MF_01024. Divergent sequence. [Tree]
InterPro	IPR001692. Histidinol_DHase. IPR012131. Hstdl_DHase_prok. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX1_SYNY3

Accession

Primary (citable) accession number: P73058

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	November 25, 2008
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)