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Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi260 – 2601ZincBy similarity
Metal bindingi263 – 2631ZincBy similarity
Active sitei330 – 3301Proton acceptorBy similarity
Active sitei331 – 3311Proton acceptorBy similarity
Metal bindingi423 – 4231ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 1 (EC:1.1.1.23)
Short name:
HDH 1
Gene namesi
Name:hisD1
Synonyms:hisD
Ordered Locus Names:slr1848
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Histidinol dehydrogenase 1PRO_0000135865Add
BLAST

Proteomic databases

PaxDbiP73058.

Interactioni

Protein-protein interaction databases

IntActiP73058. 3 interactions.
STRINGi1148.SYNGTS_0504.

Structurei

3D structure databases

ProteinModelPortaliP73058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiP73058.
KOiK00013.
OMAiWVVAAKR.
OrthoDBiEOG6CVVCR.
PhylomeDBiP73058.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P73058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRILKLSHL TPQQLNQLKR RSEQNIDQAL AIAKEVIEQV KMEGDAGVLH
60 70 80 90 100
YSRQFDFAGA TAENLRVSEA EFAEAEKLVD PELRRAVEHA FRNIEKVHAG
110 120 130 140 150
QMPPPMHLAE IEPGVFAGEK ITPLPTVGLY VPRGKGAFPS MMLMLAVPAR
160 170 180 190 200
VAGVKKIVVC TPPDKEGKVE PVSLVTARMA GVDEVYKLGG VQALAAIAYG
210 220 230 240 250
TKTVSKVDKL IGPCSIYGAA AKRLLSGIVD VGLPAGPSES IVLADETTDP
260 270 280 290 300
KLAALDLLIE AEHGSDSAAL LVTHSASLAE KALGYLGEYL EKLPPWRKKF
310 320 330 340 350
CEDGLGSYGG ILLTDSLQAS LDFINDYAPE HLQVLTADPL KLVGKIDNAG
360 370 380 390 400
EILLGNYTPS SAATYAIGVN AVLPTGGFAR SYSAVSVFDF LKRSTLAYLT
410 420 430
EEGFAGVKET VTTLADYEDF PAHALAIRER ENLL
Length:434
Mass (Da):46,534
Last modified:February 1, 1997 - v1
Checksum:i76F07AC33439B1E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17080.1.
PIRiS75166.
RefSeqiYP_005650457.1. NC_017277.1.
YP_007450284.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17080; BAA17080; BAA17080.
KEGGisyn:slr1848.
PATRICi23837958. VBISynSp132158_0548.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17080.1.
PIRiS75166.
RefSeqiYP_005650457.1. NC_017277.1.
YP_007450284.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP73058.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP73058. 3 interactions.
STRINGi1148.SYNGTS_0504.

Proteomic databases

PaxDbiP73058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17080; BAA17080; BAA17080.
KEGGisyn:slr1848.
PATRICi23837958. VBISynSp132158_0548.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiP73058.
KOiK00013.
OMAiWVVAAKR.
OrthoDBiEOG6CVVCR.
PhylomeDBiP73058.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiHISX1_SYNY3
AccessioniPrimary (citable) accession number: P73058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: June 24, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The conserved zinc-binding site Asp residue in position 364 is replaced by a Thr.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.