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P73058

- HISX1_SYNY3

UniProt

P73058 - HISX1_SYNY3

Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi260 – 2601ZincBy similarity
    Metal bindingi263 – 2631ZincBy similarity
    Active sitei330 – 3301Proton acceptorBy similarity
    Active sitei331 – 3311Proton acceptorBy similarity
    Metal bindingi423 – 4231ZincBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 1 (EC:1.1.1.23)
    Short name:
    HDH 1
    Gene namesi
    Name:hisD1
    Synonyms:hisD
    Ordered Locus Names:slr1848
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Histidinol dehydrogenase 1PRO_0000135865Add
    BLAST

    Proteomic databases

    PaxDbiP73058.

    Interactioni

    Protein-protein interaction databases

    IntActiP73058. 3 interactions.
    STRINGi1148.slr1848.

    Structurei

    3D structure databases

    ProteinModelPortaliP73058.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiGFLFHAN.
    OrthoDBiEOG6CVVCR.
    PhylomeDBiP73058.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73058-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRILKLSHL TPQQLNQLKR RSEQNIDQAL AIAKEVIEQV KMEGDAGVLH    50
    YSRQFDFAGA TAENLRVSEA EFAEAEKLVD PELRRAVEHA FRNIEKVHAG 100
    QMPPPMHLAE IEPGVFAGEK ITPLPTVGLY VPRGKGAFPS MMLMLAVPAR 150
    VAGVKKIVVC TPPDKEGKVE PVSLVTARMA GVDEVYKLGG VQALAAIAYG 200
    TKTVSKVDKL IGPCSIYGAA AKRLLSGIVD VGLPAGPSES IVLADETTDP 250
    KLAALDLLIE AEHGSDSAAL LVTHSASLAE KALGYLGEYL EKLPPWRKKF 300
    CEDGLGSYGG ILLTDSLQAS LDFINDYAPE HLQVLTADPL KLVGKIDNAG 350
    EILLGNYTPS SAATYAIGVN AVLPTGGFAR SYSAVSVFDF LKRSTLAYLT 400
    EEGFAGVKET VTTLADYEDF PAHALAIRER ENLL 434
    Length:434
    Mass (Da):46,534
    Last modified:February 1, 1997 - v1
    Checksum:i76F07AC33439B1E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17080.1.
    PIRiS75166.
    RefSeqiNP_440400.1. NC_000911.1.
    YP_005650457.1. NC_017277.1.
    YP_007450284.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17080; BAA17080; BAA17080.
    GeneIDi953700.
    KEGGisyn:slr1848.
    syy:SYNGTS_0504.
    syz:MYO_15100.
    PATRICi23837958. VBISynSp132158_0548.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17080.1 .
    PIRi S75166.
    RefSeqi NP_440400.1. NC_000911.1.
    YP_005650457.1. NC_017277.1.
    YP_007450284.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73058.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P73058. 3 interactions.
    STRINGi 1148.slr1848.

    Proteomic databases

    PaxDbi P73058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17080 ; BAA17080 ; BAA17080 .
    GeneIDi 953700.
    KEGGi syn:slr1848.
    syy:SYNGTS_0504.
    syz:MYO_15100.
    PATRICi 23837958. VBISynSp132158_0548.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi GFLFHAN.
    OrthoDBi EOG6CVVCR.
    PhylomeDBi P73058.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiHISX1_SYNY3
    AccessioniPrimary (citable) accession number: P73058
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    The conserved zinc-binding site Asp residue in position 364 is replaced by a Thr.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3