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Protein

Glutamate decarboxylase

Gene

gad

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadImported
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)Imported
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiP73043.

Interactioni

Protein-protein interaction databases

STRINGi1148.sll1641.

Structurei

3D structure databases

ProteinModelPortaliP73043.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
InParanoidiP73043.
KOiK01580.
OMAiFVGTWMD.
PhylomeDBiP73043.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

P73043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHKKIDLNQ LSEAESLLTP TYAARGLANS VSKYEMPETE MLPAIAYNLI
60 70 80 90 100
HDELGLDGNS RLNLATFVTT WMEPEARQLM ADTFDKNMID KDEYPQTAEI
110 120 130 140 150
ELRCVNILSR LWNAPASAEA TGCSTIGSSE AAMLGGMAMK WKWRQRRQAA
160 170 180 190 200
GKPGDRPNLV MGINVQVCWE KFCRYWEVEP RFVPMEGDRY HISPEEAVKL
210 220 230 240 250
IDENTIGVIG ILGSTFDGSY EPIEALNDAL ETLNQRTGWQ VPLHIDAASG
260 270 280 290 300
GFIAPFLDPD LRWDFRLPWV KSINTSGHKY GLVYPGVGWI IWRDKEELPE
310 320 330 340 350
ELIFHCNYLG GDLPNFALNF SRPGNQVVAQ YYNFLRLGKE GYRKIQQTCR
360 370 380 390 400
DTALYLSGKI AQLGPFELLT DGGDIPVFAW RLKDEVLANT CYTLYDMADK
410 420 430 440 450
LRERGWLVPA YRMPKNREDL VVQRIVVKEG FSRDMADLLL ADMERAIAYF
460
ASQPDHKPKQ EGSHFSH
Length:467
Mass (Da):53,041
Last modified:February 1, 1997 - v1
Checksum:i7C0BDFA030743153
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17064.1.
PIRiS75150.
RefSeqiNP_440384.1. NC_000911.1.
YP_005650441.1. NC_017277.1.
YP_007450268.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17064; BAA17064; BAA17064.
KEGGisyn:sll1641.
PATRICi23837924. VBISynSp132158_0531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA17064.1.
PIRiS75150.
RefSeqiNP_440384.1. NC_000911.1.
YP_005650441.1. NC_017277.1.
YP_007450268.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP73043.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1148.sll1641.

Proteomic databases

PaxDbiP73043.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17064; BAA17064; BAA17064.
KEGGisyn:sll1641.
PATRICi23837924. VBISynSp132158_0531.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
InParanoidiP73043.
KOiK01580.
OMAiFVGTWMD.
PhylomeDBiP73043.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / KazusaImported.

Entry informationi

Entry nameiP73043_SYNY3
AccessioniPrimary (citable) accession number: P73043
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: April 1, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.