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P73033

- GPDA_SYNY3

UniProt

P73033 - GPDA_SYNY3

Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881NAD; via amide nitrogenUniRule annotation
    Binding sitei88 – 881SubstrateUniRule annotation
    Binding sitei120 – 1201NAD; via amide nitrogenUniRule annotation
    Active sitei171 – 1711Proton acceptorUniRule annotation
    Binding sitei235 – 2351NADUniRule annotation
    Binding sitei261 – 2611NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 216NADUniRule annotation

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Source: UniProtKB-HAMAP
    2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    3. glycerol-3-phosphate dehydrogenase [NADP+] activity Source: UniProtKB-EC
    4. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate biosynthetic process Source: UniProtKB-HAMAP
    3. glycerol-3-phosphate catabolic process Source: InterPro
    4. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
    5. phospholipid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00940.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
    Alternative name(s):
    NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
    Gene namesi
    Name:gpsAUniRule annotation
    Ordered Locus Names:slr1755
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Glycerol-3-phosphate dehydrogenase [NAD(P)+]PRO_0000138047Add
    BLAST

    Proteomic databases

    PaxDbiP73033.

    Interactioni

    Protein-protein interaction databases

    IntActiP73033. 1 interaction.
    STRINGi1148.slr1755.

    Structurei

    3D structure databases

    ProteinModelPortaliP73033.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni235 – 2362Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0240.
    HOGENOMiHOG000246853.
    KOiK00057.
    OMAiLECEYLI.
    OrthoDBiEOG6JDWF4.
    PhylomeDBiP73033.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS00957. NAD_G3PDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P73033-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFANADTPP QVVVLGAGAW GSSLAYVLNN NDIPTQVWSR RSPQSLESMV    50
    AGADVIVSAV SIKGVPSVAA RLEAMDLQRR TILVTATKGL DPETMTTPSQ 100
    IWQAALPSQP IAVLSGPNLS KEIDQGLPAA TVVASSDQAA AEEIQTIFAA 150
    DNFRVYTNND PLGTELGGTL KNVMAIAVGV CEGLGLGTNA KSALITRALP 200
    EITRVGLHFG AQPDTFWGLA GLGDLLATCS SMLSRNYRVG YGLSKGQSLE 250
    EILANLGGTA EGVNTTDVLI KIANREKIAV PITRQVYRLL HGKITPPQAV 300
    EALMERELKA EFEDFDL 317
    Length:317
    Mass (Da):33,511
    Last modified:June 1, 2001 - v2
    Checksum:i1335A86E1B6E0935
    GO

    Sequence cautioni

    The sequence BAA17053.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17053.1. Different initiation.
    PIRiS75139.
    RefSeqiNP_440373.1. NC_000911.1.
    YP_007450257.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17053; BAA17053; BAA17053.
    GeneIDi953673.
    KEGGisyn:slr1755.
    syz:MYO_14830.
    PATRICi23837904. VBISynSp132158_0521.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17053.1 . Different initiation.
    PIRi S75139.
    RefSeqi NP_440373.1. NC_000911.1.
    YP_007450257.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73033.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P73033. 1 interaction.
    STRINGi 1148.slr1755.

    Proteomic databases

    PaxDbi P73033.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17053 ; BAA17053 ; BAA17053 .
    GeneIDi 953673.
    KEGGi syn:slr1755.
    syz:MYO_14830.
    PATRICi 23837904. VBISynSp132158_0521.

    Phylogenomic databases

    eggNOGi COG0240.
    HOGENOMi HOG000246853.
    KOi K00057.
    OMAi LECEYLI.
    OrthoDBi EOG6JDWF4.
    PhylomeDBi P73033.

    Enzyme and pathway databases

    UniPathwayi UPA00940 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    HAMAPi MF_00394. NAD_Glyc3P_dehydrog.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS00957. NAD_G3PDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiGPDA_SYNY3
    AccessioniPrimary (citable) accession number: P73033
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3