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P73033 (GPDA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]

EC=1.1.1.94
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Gene names
Name:gpsA
Ordered Locus Names:slr1755
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H. HAMAP-Rule MF_00394

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism. HAMAP-Rule MF_00394

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00394.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence caution

The sequence BAA17053.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Glycerol-3-phosphate dehydrogenase [NAD(P)+] HAMAP-Rule MF_00394
PRO_0000138047

Regions

Nucleotide binding16 – 216NAD By similarity
Region235 – 2362Substrate binding By similarity

Sites

Active site1711Proton acceptor By similarity
Binding site881NAD; via amide nitrogen By similarity
Binding site881Substrate By similarity
Binding site1201NAD; via amide nitrogen By similarity
Binding site2351NAD By similarity
Binding site2611NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P73033 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 1335A86E1B6E0935

FASTA31733,511
        10         20         30         40         50         60 
MSFANADTPP QVVVLGAGAW GSSLAYVLNN NDIPTQVWSR RSPQSLESMV AGADVIVSAV 

        70         80         90        100        110        120 
SIKGVPSVAA RLEAMDLQRR TILVTATKGL DPETMTTPSQ IWQAALPSQP IAVLSGPNLS 

       130        140        150        160        170        180 
KEIDQGLPAA TVVASSDQAA AEEIQTIFAA DNFRVYTNND PLGTELGGTL KNVMAIAVGV 

       190        200        210        220        230        240 
CEGLGLGTNA KSALITRALP EITRVGLHFG AQPDTFWGLA GLGDLLATCS SMLSRNYRVG 

       250        260        270        280        290        300 
YGLSKGQSLE EILANLGGTA EGVNTTDVLI KIANREKIAV PITRQVYRLL HGKITPPQAV 

       310 
EALMERELKA EFEDFDL 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA17053.1. Different initiation.
PIRS75139.
RefSeqNP_440373.1. NC_000911.1.
YP_007450257.1. NC_020286.1.

3D structure databases

ProteinModelPortalP73033.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP73033. 1 interaction.
STRING1148.slr1755.

Proteomic databases

PaxDbP73033.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17053; BAA17053; BAA17053.
GeneID14615905.
953673.
KEGGsyn:slr1755.
syz:MYO_14830.
PATRIC23837904. VBISynSp132158_0521.

Phylogenomic databases

eggNOGCOG0240.
HOGENOMHOG000246853.
KOK00057.
OMAIIYSENE.
OrthoDBEOG6JDWF4.
PhylomeDBP73033.
ProtClustDBPRK14619.

Enzyme and pathway databases

UniPathwayUPA00940.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
HAMAPMF_00394. NAD_Glyc3P_dehydrog.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 2 hits.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPDA_SYNY3
AccessionPrimary (citable) accession number: P73033
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways